Influence of two different cement space settings and three different cement types on the fit of polymer-infiltrated ceramic network material crowns manufactured using a complete digital workflow

The study evaluates the influence of two spacer settings and three resin luting materials on the marginal and internal fit of polymer-infiltrated ceramic network (PICN) material crowns manufactured using a complete digital workflow. Optical impressions of fifty identical dies were performed using the 3M scanner (software version 5.0.2). Twenty crowns were designed using Ceramill Mind (version 3.4.10.1163), from which ten with spacer setting of 50 μm (G1) and ten with 80 μm (G2). Thirty crowns (spacer setting of 50 μm) were divided into three groups corresponding to the resin materials used as follows: RelyX Unicem (RX), Variolink Esthetic (VLE), and Nexus 3 (NX3). All crowns were milled from Vita Enamic blocks. After micro-CT scanning, absolute marginal discrepancy (AMD), internal gap (IG), total cement space volume (TCV), and marginal porosities (VP) were measured. Significant difference was detected on the VP between the RX and NX3 group (p = 0.033). The mean values of all parameters were the following: AMD (μm): G1 182.6, G2 253.7, RX 210.8, VLE 195.5, NX3 186.6; IG (μm): G1 215.6, G2 173.1, RX 171.1, VLE 198.6, NX3 203; TCV (mm3): G1 22.9, G2 20.49, RX 17.57, VLE 17.49, NX3 20.59; VP (mm3): G1 0.26, G2 0.34, RX 0.32, VLE 0.46, NX3 0.54. Fit of PICN material crowns was not significantly influenced by increasing the spacer settings and cementation with different resin materials. Additionally, RelyX Unicem showed significantly less porosities as compared with Nexus3. Both 50 μm and 80 μm virtual spacer settings can be suggested for the manufacture of PICN crowns when Ceramill Mind (version 3.4.10.1163) is used. Furthermore, a self-adhesive system can be recommended for the cementation.


Introduction
CAD/CAM (computer-aided design/computer-aided manufacturing) technologies strongly enhanced the development of highly esthetic materials for the chair-side use in restorative dentistry [1]. Vita Enamic (Vita Zahnfabrik, Bad Säckingen, Germany), for example, is a representative material consisting of a fine glass ceramic three-dimensional network which is infiltrated with a mixture of urethane dimethac rylate (UDMA) and t rie thylene glycol dimethacrylate (TEGDMA) monomers [2,3]. This composition provides ceramic-like characteristics such as fine surface structure and good esthetic properties. Furthermore, the reduced brittleness and higher fracture toughness is favorable against loading forces and enhances the milling procedure in the manufacturing process of the restoration [4]. In addition, the polymer structure enables the generation of smoother and thinner margins with fewer irregularities which on one hand support the preservation of tooth structure and on the other hand enhance the accuracy in the marginal area of the restoration [5].
Adequate accuracy of fit is crucial for the long-term success of dental restorations [6]. Holmes et al. established measuring parameters to define the accuracy of fit and moreover to compare the results of various studies. The absolute marginal discrepancy (AMD) represents the distance that reflects the largest error in the marginal area of a restoration and the internal gap (IG) reflects the errors in the internal cement space [7]. Different reference values for AMD and IG have been defined as clinically acceptable; however, most of the authors agree that marginal gaps below 120 μm are suitable for an adequate fit [8]. An evenly distributed cement layer with low IG values is important for the correct seating and ensures better mechanical properties [6]. Various methods have been described regarding the evaluation of fit of restorations using either a destructive or a non-destructive approach [9]. The evaluation with micro-CT, a non-destructive method, allows not only 2D measurements of distances like AMD and IG but also the quantification of the cement space volume and the volume of porosities inside the luting agent. Consequently, the accuracy of the final restoration can be assessed after cementation as well as in-between working steps [10].
Every working step conducted during the clinical procedure or throughout the CAD/CAM manufacturing process influences the accuracy of fit of the restoration. Besides the preparation design, the impression technique, and the milling procedure, the setting of the cement space in the design software and the cementation procedure with the luting agent itself play a crucial role [6,11,12]. A certain width of the cement space provides space for the luting agent and facilitates its distribution in the axial area [13]. The width of the cement space affects both the internal gap dimension and the marginal gap. However, to our knowledge, regarding polymer-infiltrated ceramic network (PICN) material crowns, exact recommendations for spacer settings in the design software are still missing. Iwai et al., for example, concluded that zirconia copings with a cement space set to 60 μm showed better marginal adaptation than copings with cement space set to 10 and 30 μm [14]. Similarly, Kale et al. reported that cement space settings greater than 30 μm improve the marginal fit of monolithic zirconia crowns [11], while Yildirim et al. found clinically acceptable marginal and internal adaptation values for PICN material crowns using spacer settings of 40 μm [15]. Furthermore, according to Shim et al., spacer settings of 80 μm showed better repeatability of marginal and internal fit values [16]. Due to these discrepancies, one aim of this study was to compare the influence of two different spacer settings (50 μm and 80 μm) on the marginal and internal gap, the cement volume, and the volume of porosities in the marginal area of PICN material crowns.
Besides the spacer setting, the choice of a convenient luting agent and the cementation procedure itself influence the accurate seating and the final marginal and internal discrepancies of the restoration [12]. Furthermore, in order to achieve a better marginal seal and prevent an adhesion failure, proper pre-treatments of the inner surface of PICN material restorations are necessary. According to Peumans et al. Vita Enamic blocks show better adhesion results when a pre-treatment with hydrofluoric acid and silane is performed [17]. The selection of the luting agent is based on various factors such as the type of restoration, the material properties, the preparation design, and the physical and chemical characteristics of the material [18]. However, despite an accurate choice of the luting agent and correct seating, the formation of porosities in the cement space during the cementation procedure could negatively influence the long-term success of the restoration. Factors like the mixing method of the luting agent or the particle size might amplify the formation of porosities [19]. Considering the importance of the right selection of the luting agent, the second aim of the study was to evaluate the influence of three different resin luting materials on the marginal and the internal gap of PICN material crowns. Furthermore, the cement space volume and the volume of porosities in the marginal area of PICN material crowns were investigated.

Preparation
Preparation of a right mandibular typodont tooth (KaVo Dental, Biberach, Germany) was conducted for a crown restoration with a PICN material (Vita Enamic). The circumferential reduction was 0.8-1.2 mm with a convergence angle of 6°including a chamfer finish line of 0.8 mm. The occlusal reduction amounted 1.5 mm. The master die was then replicated 50 times using a high-quality vinyl silicone (DUOSIL D, SHERA Werkstoff-Technologie, Lemförde, Germany) and a highly precise model resin (Mirapont, Hager & Werken, Duisburg, Germany). For the first aim of the study, 20 dies were randomly chosen and divided into two groups of ten each, whereas for the second aim, the remaining 30 dies were divided into three groups (Fig. 1).
All dies were marked with a number and fixed in a silicone holder for the impression taking procedure.

Digital impression and crown fabrication
The dies were digitized using the 3M TDS intra-oral scanner (3M ESPE, Seefeld, Germany, software version 5.0.2). Before the scanning process, the dies were sprayed with a titanium dioxide-based sprayer (3M High-Resolution Sprayer, 3M ESPE) according to the manufacturer's protocol and digitized starting with the occlusal surface then continuing to the lingual and buccal surface. Afterwards, the data were uploaded to the 3M servers and made available for download. Subsequently, the 3D data were imported into the design software (Ceramill Mind, Amman Girrbach GmbH, Pforzheim, Germany, version 3.4.10.1163) for the virtual design of the PICN material crowns. All designing and manufacturing steps were conducted by an experienced dental technician.
For the first aim of the study, the crowns of the first group were designed with a spacer setting of 50 μm for the internal gap and 0 μm for the marginal gap. The crowns of the second group were designed with an internal gap of 80 μm and marginal gap of 0 μm.
For the second aim, the crowns of all three groups were designed with the same fitting parameters-an internal gap of 50 μm and marginal gap of 0 μm.
All crowns were milled from PICN material blocks (Vita Enamic) in a 5 axis milling machine (Ceramill Motion 2 (5×), Amman Girrbach GmbH, software version 3.4.8). Prior to cementation, the crowns were placed on their respective dies and checked for irregularities using a microscope at × 10 magnification (Stemi DV4 Spot, Carl Zeiss Microscopy, Jena, Germany).

Cementation procedure
For the first aim, the crowns of both groups were cemented using self-adhesive universal resin material (RelyX Unicem Aplicap, 3M ESPE). A hydrofluoric acid gel (VITA CERAMICS ETCH (5%), Vita Zahnfabrik GmbH) for etching was applied for 60 s in the inner surface of the crowns and rinsed with water for 60 s. Subsequently, the surface was silanated (Monobond Plus, Ivoclar Vivadent AG, Schaan, Liechtenstein). Afterwards, the resin material was mixed for 10 s in a capsule mixing unit (RotoMix, 3M ESPE) and applied in the crowns, which had been seated on their respective dies using finger pressure for 2-3 s. The specimens were placed instantly in a seating pressure device for 5 min, where a standardized pressure of 20 g/mm 2 through a plunger was exerted as described by Goracci et al. [20]. At the same time, residual resin material was removed using foam pellets (Pele Tim, Voco, Cuxhaven, Germany), and subsequently, a light curing of the material was performed on each surface of the crown (mesial, distal, buccal, and lingual) for 20 s using a curing lamp (Bluephase 20i, Ivoclar Vivadent AG) with an intensity of 1200 mW/cm 2 .
For the second aim, the crowns of the three groups were pretreated in the same manner as described above. The crowns of the first group (RX) were cemented using RelyX Unicem Aplicap. The crowns of the second group (VLE) were cemented using a dual-curing resin-based material (Variolink Esthetic DC, Ivoclar Vivadent). Prior to cementation, the dies were treated with a self-etching primer (AdheSE Primer, Fig. 1 Study workflow showing the manufacturing, the cementation, and the measuring process Ivoclar Vivadent) for 30 s and then dried with air. An adhesive (AdheSE bonding agent, Ivoclar Vivadent) was applied on the prepared surface, scrubbing it for 20 s and then light-cured for 10 s using the Bluephase 20i at an intensity of 1200 mW/cm 2 . In the internal surface of the crown, Variolink Esthetic DC cement was applied with an automix syringe, and the crowns were seated on their respective dies in the same way as described above. Glycerine gel was applied to the margins after residual resin material removal in order to prevent oxygen inhibition of polymerization. The third group (NX3) of the crowns was cemented also using resin-based material (Nexus 3, Kerr Corporation, Orange, USA). The working steps for the pre-treatment, seating, and curing were the same as in the previous group with the difference that OptiBond XTR (Kerr Corporation) was used as a primer by scrubbing it for 15 s and by thin drying with air for 5 s. The adhesive (OptiBond XTR, Kerr Corporation) was applied and then dried for 15 s respectively. All used materials with their composition and the manufacturers are listed in Table 1.
After the cementation process, all specimens were cleaned with alcohol 70% vol. and checked for irregularities under microscope prior to micro-CT scan (Fig. 2).

Micro-CT scan and measurements
A 3D inspection device with a semi-automatic X-ray (Viscom X8060, Viscom AG, Hannover, Germany) was used to perform the scans of the cemented crowns. The device was operated at 130 kV with tube current of 160 μA using a 5-mm Cufilter. Calibration and image correction were performed before every scan procedure in order to achieve the best possible contrast. For each specimen, 1440 images were carried out with a resolution of 9.77 μm per pixel. The reconstruction of the data was performed using reconstruction software (XVR-CT, Viscom AG, software version 1.07) with a resolution of 10 μm per voxel. The reconstructed files (CTR) were converted into tagged image file format (TIFF) for the subsequent segmentation and measuring procedure.
The segmentation of the reconstructed files was performed using segmentation software (Definiens Developer XD 2.1.1, Definiens AG, Munich, Germany). In the first step, a rough pre-segmentation was performed in order to achieve a relative separation of the background, the die, the crown, and the cement space.
In the further steps, the objects were optimized by several different intensity thresholds and surface tension constraints to ensure that the gap was not bridged where it was very narrow. Finally, a region of 200 μm around the cement space was improved, and the threshold was determined to detect the porosities inside the cement layer (letter D in Fig. 3) and the porosities in contact with the external environment, as shown with letter B in Fig. 3. Volumetric measurements of the total cement space (TCV) and porosities in contact with the external environment (VP) were directly performed with Definiens. The absolute marginal discrepancy (AMD), which represents the distance between the preparation margin and the crown margin (distance A in Fig. 3) as defined by Holmes et al. [7], was measured in 150 equidistant points circumferentially  using Image J. The internal gap, which is the distance between the crown inner surface and the surface of the die (distance C in Fig. 3), was measured with the BoneJ Plugin for Image J using the Tb.Th (trabecular thickness) algorithm [21][22][23]. The cement space thickness and the porosities of representative specimens of each group are shown in Fig. 4. Representative micro-CT images with visualization of porosities in the marginal area with contact to the external environment are displayed in Fig. 5. More details on the segmentation and the measuring process are available in a previous publication of the authors [24].

Statistical analysis
The statistical analysis was performed using SPSS Statistics (IBM Corporation, Armonk, USA, version 21) at a significance level of 95%. Mean value, minimum, maximum, and standard deviation for the measuring parameters were calculated. The data are represented using vertical bar charts with standard deviations.
For the first aim, the assumption of homogeneity of variance was tested using Levene statistics. To meet the need for non-parametric testing, Mann-Whitney U tests were performed to compare the two groups.
For the second aim, the homogeneity of variance was also tested with Levene statistics and the three groups were compared using one-way ANOVA followed by a post hoc Tukey test.

Results
Influence of the cement space setting: 50 μm versus 80 μm The micro-CT analysis and the measuring software made it possible to carry out 150 circumferential measurements of AMD on each crown and also to determine the mean IG for the whole cement space as well as the volumetric quantification of the TCV and VP. Table 2 shows the mean values, minimum, maximum, and standard deviations of AMD, IG, TCV, and VP of the crowns manufactured with an internal gap of 50 μm and 80 μm. The mean values for the 50 μm group were the following: AMD 182.6 μm, IG 215.6 μm, TCV 22.9 mm 3 , and VP 0.26 mm 3 . The 80 μm group showed the following mean values: AMD 211.9 μm, IG 173.1 μm, TCV 20.49 mm 3 , and VP 0.34 mm 3 . The statistical analysis revealed no significant difference in the measured parameters between both groups (p > 0.05). Table 3 shows the mean values, minimum, maximum, and standard deviations of AMD, IG, TCV, and VP of the crowns cemented with three different resin materials. The mean values of the RX group were the following: AMD 210.8 μm, IG 171.1 μm, TCV 17.57 mm 3 , and VP of 0.32 mm 3 . VLE group mean values were the following: AMD 195.5 μm, IG 198.6 μm, TCV 17.49 mm 3 , and VP 0.46 mm 3 . The NX3 group showed following values: AMD 186.6 μm, IG 203 μm, TCV 20.59 mm 3 , and VP of 0.54 mm 3 . The statistical analysis showed a significant difference between the RX and NX3 group in the volume of porosities in the marginal area (p = 0.033). No significant differences were found regarding the other parameters.

Discussion
The purpose of the present study was to investigate the influence of two different fitting parameters and three different resin luting materials in the marginal and internal fit of polymer-infiltrated ceramic network crowns manufactured after digital impressions with the 3M true definition scanner.
Based on the micro-CT measurements, the comparison of two different virtual cement space settings showed no statistically significant difference with regard to the parameters for accuracy of fit. The mean AMD values were 182.6 μm for the 50 μm group and 211.9 μm for the 80 μm group. These results indicate that an increase of the cement space to 80 μm does not improve the marginal fit of the PICN crowns as proposed by Shim et al. [16]. Compared with the results of Yildirim et al., who measured a mean AMD of 102.4 μm for Vita Enamic crowns, the AMD values of both groups in the present study are higher [15]. A possible explanation for these results might be that Yildirim et al. used another intra-oral scanner for the impression taking process and a different milling unit. A more plausible explanation could be that the crowns were not cemented but only stabilized on their respective dies with a silicone material as well as the fact that there was a different cement space width of 40 μm [12,25]. The mean AMD data of the 50 μm group in the present study showed also higher values when compared with a previous investigation conducted by Dauti et al. [24]. However, all experiments of both studies were conducted in identical conditions using the same intra-oral scanner and same fitting parameters. Most likely, the reason for these discrepancies might be the influence of the operator, the dental technician, and the cementation procedure, which cannot be entirely standardized. Regarding the IG, the mean value for the 50 μm group was 215.6 μm and 173.1 μm for the 80 μm group, respectively. An evenly distributed cement space is important for acceptable mechanical properties and good retention of the restoration [26,27]. According to Liu et al., higher luting material thickness allows for a higher degree of flexure of the crown, thus causing larger tensile stress in the core of the crown. On the other hand, a thinner layer hinders the full absorption of mechanical energy by the luting material, thus also increasing the stress in the crown. These findings imply that the cement space thickness is of secondary importance compared with the influence of loading conditions or cement moduli [28]. The mean IG values of both groups do not reproduce the configured cement spaces in the design software, which is consistent with the results of previous research [14,15,29]. One explanation could be the preparation design, especially the convergence angle of the axial walls, which might affect the accuracy of fit. An increase in the convergence angle might possibly produce lower internal gap values [14]. The total volume of the cement space showed no significant difference between both groups, regardless of the space setting. Considering the fact that both groups had no significant difference between the measured The second part of the investigation evaluated the influence of three different resin luting materials, RelyX Unicem (RX), Variolink Esthetic DC (VLE), and Nexus 3 (NX3), on the marginal and internal fit of cemented PICN material crowns. A significant difference between the groups was only found in the porosities in the cement space on the marginal area, which might negatively influence the long-term success of the restoration. The RX group showed the lowest mean volume of porosities. The other measured parameters showed no statistical difference. The mean AMD value for the RX group was 210.8 μm, for the VLE group 195.5 μm and for the NX3 group 186.6 μm. The RX group resulted in approximately 30 μm higher mean AMD compared with the aforementioned 50 μm group and about 70 μm higher AMD compared with a previous study by the authors, even though the manufacturing and cementation process took place under identical conditions [12]. The VLE group showed lower mean AMD values compared with a study conducted by Peroz et al. that investigated the marginal fit of cemented lithium disilicate ceramic crowns using 3 different luting materials, in which a mean AMD value of 412 μm was measured for the Variolink group. On the other hand, the RelyX Unicem group showed a mean AMD of 213 μm, which is similar to the RX group of the present study [30]. For the NX3 group, no studies could be found to compare the marginal fit values. It is important to mention that Peroz et al. used different materials for the manufacture of the crowns compared with the present study. According to Azarbal et al., materials in which a crystallization firing is involved like, e.g., lithium disilicate (IPS e.max CAD) show poorer marginal adaptation compared with materials like Vita Enamic, which do not require this extra step [31]. IG mean values were 171.1 μm for the RX group, 198.6 μm for the VLE group, and 203 μm for the NX3 group. Taken together, the AMD, IG, and TCV data of the cemented PICN crowns with 3 different resin luting materials showed variability between the groups, however, without a statistical significance between them. According to research, RelyX Unicem builds a film thickness of 15.1 μm 1 min after mixing [32], while Variolink showed an initial film thickness between 18.4 μm [33] and 22.2 μm [34]. For Nexus 3, no data on film thickness were found. However, previous research on Nexus 2 detected a film thickness value of 18.6 μm [34]. Correspondent with the ISO 9917 norm, these values are below the maximum specified value of 25 μm for water-based cements [33], which theoretically should also apply to resin-based luting materials. It can therefore be assumed that the film thickness of the 3 tested materials should not affect the proper seating of the crowns. Nevertheless, all three groups had mean AMD values above the 120-μm threshold for clinically acceptable margins [8]. In addition to factors like the impression technique and the manufacturing procedure, possible reasons for the higher values could have been the convergence angle of the axial walls, the seating pressure during cementation, and the flowing properties of the luting materials [14,35]. Lower  Clin Oral Invest (2020) 24:1929-1938 AMD values might have been achieved if dynamic loading during the seating of the crowns had been performed [35,36]. The manufacture of the crowns in this study was done strictly digitally, including the impression procedure, the virtual design, and the milling of the crowns. This process, compared with the conventional manufacture of restorations, eliminates some working steps; however, it introduces new variables, e.g., software versions of the intra-oral scanner and the designing software which could influence the overall adaptation of the restoration. Shim et al. examined the influence of different software versions of the intra-oral scanner and design software of a CEREC system on the accuracy of crowns milled from resin nano-ceramic blocks, concluding that later software versions produce more accurate restorations [16]. Consequently, the results of this investigation apply for the devices that are used in the study with the software versions as stated above and might be different from newer versions. The material used for the fabrication of the dies was resinbased and clearly could not mimic a prepared tooth. Nevertheless, we decided to treat the die surface as if it was dentine in order to better simulate the clinical situation. In this case, the primer used in the VLE and NX3 group does not generate a hybrid layer with the die surface, which according to Loguercio et al. can compensate the stress that occurs during polymerization [37]. Cautiously interpreted, the stress during polymerization can lead to debonding and subsequently to an increase of the marginal discrepancies and porosities. Adjustments on the inner surface of the crowns before cementation to eliminate possible premature contacts between the crown and the die were not performed, in order to avoid biasing of the marginal values [38]. However, premature contacts could have also influenced the proper seating of the crown and subsequently increase the marginal discrepancies. The evaluation of accuracy fit of restorations by micro-CT gives a more detailed view of the relation between the restoration, luting agent, and the die. Considering this fact, it is difficult to interpret and compare the results with previous studies because of variations in the number of measurements per specimen, variety of the measuring points, and the sample size [9]. In the present study, the AMD was measured in 150 equidistant points circumferentially on the crown margin. Moreover, the IG was calculated as a mean value for the whole cement space. Consequently, with the high number of measurements, many of the discrepancies on the margin and the internal space are detected. These can subsequently lead to higher values of AMD and IG.
Porosities in the cement space on the marginal area with contact to the external environment were detected in all investigations. This fact is of clinical importance, since fluids, bacteria, and bacterial toxins can penetrate these spaces and get access to the unprotected dentin, compromising the success of the restoration [39]. When comparing the 50 μm and 80 μm group, no statistical difference between the groups was found.
The mean VP value of the 50 μm group was 0.26 mm 3 , which is consistent with a previous study by the authors [24]. On the other hand, the 80 μm group had a slightly elevated mean VP of 0.34 mm 3 . It seems that an increase in the cement gap to 80 μm does not significantly affect the VP. However, a statistically significant difference was noticed between the RX and NX3 group. The mean VP volume of the RX group was 0.32 mm 3 , which is in agreement with the previous research by the authors [24]. NX3 had a mean VP volume of 0.54 mm 3 and VLE a mean VP volume of 0.46 mm 3 . Research reveals that factors such as differences in particle size and mixing technique might contribute to the formation of porosities [19,40]. RelyX Unicem has an approximate particle size of 12.5 μm compared with Nexus 3 with a particle size of 0.6 μm and Variolink Esthetic with a particle size of 0.1 μm. Cautiously interpreting these findings, we assume that the resin material with the larger particle size produced less porosities in the marginal area. The mixing procedure for all three materials was performed according to the manufacturer's instructions. In accordance with previous research, hand mixing of luting agents leads to more air inclusion compared with automatic mixing [41]. Unlike VLE and NX3, which were mixed in the automix syringe, the RX was mixed in a Rotomix capsule mixing unit. The Rotomix mixing unit could be in this case more effective in removing porosities inside the resin material due to its rotational and centrifugal action causing the large pores to break during the initial mixing process [42]. In whichever way and however they occurred, porosities formed in the cement space can be considered destructive not only because of the penetration of fluids and bacteria but also mechanically, as it allows deformation of the material under loading conditions [40].
This study has limitations due to the in vitro setting of the experiments. Clinical factors including patients' movements during the impression procedure, subgingival preparation margins, or contaminations with blood or saliva cannot be taken into consideration. Also, the digitization of the dies without the adjacent teeth could have influenced the accuracy of the impression. Furthermore, the cementation procedure by firstly using finger pressure by the operator can influence the correct placement of the crown and might lead to larger discrepancies on a particular site. In addition, PICN material, luting agent, and the resin show similar X-ray absorption coefficients whereby the correct recognition of the borders between these materials is affected, resulting in either wider or thinner gaps. On the other hand, with this study, we were able to test the accuracy of the whole digital manufacturing process of PICN crowns including the cementation procedure using high-resolution micro-CT imaging combined with modern measuring and visualizing software. Furthermore, we accomplished to detect and visualize porosities in each of the resin materials used and quantify those appearing in the marginal area. Further research should be conducted on testing of the latest CAD/CAM workflows and on methods minimizing the appearance of porosities in the cement space.

Conclusions
In summary, within the limits of this study, we can conclude that different virtual spacer settings of 50 μm and 80 μm when Ceramill Mind (software version 3.4.10.1163) is used had no significant influence on the marginal and internal fit of cemented PICN material crowns. Additionally, no significant difference was found on the marginal and internal fit when PICN material crowns were cemented using three different resin-based materials. Porosities in the marginal area were found in all five groups, however, with significantly less porosities when using RelyX Unicem compared with Nexus 3. Since porosities in the cement space present a negative factor in the long-term survival of restorations, further research should be undertaken with focus on minimizing porosities.