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TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT

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Abstract

Introduction

Trabecular bone score (TBS) estimates bone microstructure, which is directly measured by high-resolution peripheral quantitative computed tomography (HRpQCT). We evaluated the correlation between these methods and TBS influence on fracture risk assessed by FRAX.

Materials and methods

We evaluated 129 individuals (82 women, 43 postmenopausal) 20 to 82.3 years without prevalent clinical or non-clinical morphometric vertebral fractures, using DXA (spine and hip), HR-pQCT at distal radius (R) and tibia (T) and TBS which classifies bone microarchitecture as normal (TBS ≥ 1.350), partially degraded (1.200 < TBS < 1.350), or degraded (TBS ≤ 1.200).

Results

Spine and hip BMD and HR-pQCT parameters at cortical bone: area (T), density (R,T) thickness (T) and trabecular bone: density (R,T), number (T) and thickness (R) were significantly better in the 78 individuals with normal TBS (group 1) versus the 51 classified as partially degraded (n = 42) or degraded microarchitecture (n = 9) altogether (group 2). TBS values correlated with age (r = − 0.55), positively with spine and hip BMD and all cortical and trabecular bone density and microstructure parameters evaluated, p < 0.05 all tests. Binary logistic regression defined age (p = 0.008) and cortical thickness (p = 0.018) as main influences on TBS, while ANCOVA demonstrated that HR-pQCT data corrected for age were not different between TBS groups 1 and 2. TBS adjustment increased FRAX risk for major osteoporotic fractures and hip fractures.

Conclusion

We describe significant association between TBS and both trabecular and cortical bone parameters measured by HR-pQCT, consistent with TBS influence on fracture risk estimation by FRAX, including hip fractures, where cortical bone predominates.

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Acknowledgements

The authors are grateful to the postgraduate students who selected individuals as control group for their studies: Aline Moraes, Felipe Oliveira, Eduardo Madeira and Graziella Mendonça.

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Authors and Affiliations

  1. Division of Endocrinology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil

    E. M. F. Gama, F. P. Paranhos-Neto, L. Vieira Neto, M. Madeira & M. L. F. Farias

  2. Division of Rheumatology of Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro (HUCFF-UFRJ), Avenida Professor Rodolpho Paulo Rocco 255, 21941-913, Rio de Janeiro, RJ, Brasil

    L. M. C. Mendonça

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  1. E. M. F. Gama
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Eduardo Medeiros Ferreira da Gama, Maria Lucia Fleiuss Farias and Leonardo Vieira Neto. The first draft of the manuscript was written by Eduardo Medeiros Ferreira da Gama, Maria Lucia Fleiuss Farias and Leonardo Vieira Neto and all authors commented on previous versions of the manuscript. All authors approved the final manuscript.

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Correspondence to E. M. F. Gama.

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Gama, E.M.F., Mendonça, L.M.C., Paranhos-Neto, F.P. et al. TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT. J Bone Miner Metab 42, 352–360 (2024). https://doi.org/10.1007/s00774-024-01508-4

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  • DOI: https://doi.org/10.1007/s00774-024-01508-4

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