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Association between dietary intake of α-tocopherol and cadmium related osteoporosis in population ≥ 50 years

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Abstract

Introduction

To analyze the association between α-tocopherol intake and cadmium (Cd) exposure and osteoporosis in population ≥ 50 years.

Materials and methods

Sociodemographic data, physical examination, and laboratory indicators including serum Cd level and dietary α-tocopherol intake of 8459 participants were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. The associations between α-tocopherol intake, serum Cd levels and osteoporosis were evaluated using univariate and multivariate logistic regression analyses, with the estimated value (β), odds ratios (ORs) and 95% confidence intervals (CIs). We further explored the impact of α-tocopherol intake on Cd exposure and the bone mineral density (BMD) in total femur and femur neck.

Results

A total of 543 old adults suffered from osteoporosis. The serum Cd level (0.52 μg/L vs. 0.37 μg/L) and α-tocopherol intake (5.28 mg vs. 6.50 mg) were statistical different in osteoporosis group and non-osteoporosis group, respectively. High level of Cd exposure was related to the increased risk of osteoporosis [OR = 1.60, 95% CI (1.15–2.21)]. In the total femur, α-tocopherol intake may improve the loss of BMD that associated with Cd exposure [β = − 0.047, P = 0.037]. Moreover, high α-tocopherol intake combined with low Cd exposure [OR = 0.54, 95% CI (0.36–0.81)] was linked to the decreased risk of osteoporosis comparing with low α-tocopherol intake combined with high Cd exposure.

Conclusion

High α-tocopherol intake may improve the Cd-related osteoporosis and loss of BMD that could provide some dietary reference for prevention of osteoporosis in population ≥ 50 years old.

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Authors and Affiliations

  1. Department of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, Section 3, Renmin South Road, Wuhou District, Chengdu, 610041, Sichuan, People’s Republic of China

    Renjia Li, Jinyao Chen & Lishi Zhang

  2. Department of Clinical Nutrition, Yan’an Hospital of Kunming City, No. 245 Renmin East Road, Panlong District, Kunming, 650051, Yunnan, People’s Republic of China

    Renjia Li

  3. Department of Intensive Care Unit, Yan’an Hospital of Kunming City, Kunming, 650051, Yunnan, People’s Republic of China

    Hai Qu

  4. Department of Police Sports and Actual Combat Teaching, Yunnan Police Officer Academy, Kunming, 650223, Yunnan, People’s Republic of China

    Jinwei Xu

  5. Department of Orthopedic, Yan’an Hospital of Kunming City, Kunming, 650051, Yunnan, People’s Republic of China

    Huiqin Yang

  6. Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Jiuming Yan

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  1. Renjia Li
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Li, R., Qu, H., Xu, J. et al. Association between dietary intake of α-tocopherol and cadmium related osteoporosis in population ≥ 50 years. J Bone Miner Metab 41, 501–511 (2023). https://doi.org/10.1007/s00774-023-01418-x

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  • DOI: https://doi.org/10.1007/s00774-023-01418-x

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