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Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm

  • Original Article - Functional Neurosurgery - Other
  • Published:
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Abstract

Background

The pathophysiology of neurovascular compression syndrome has not been fully elucidated, and cerebrospinal fluid levels of nerve tissue-related markers involved in this disorder have not yet been reported.

Methods

We measured cerebrospinal fluid levels of S100B protein, neuron-specific enolase, and myelin basic protein in 21 patients with trigeminal neuralgia, 9 patients with hemifacial spasms, and 10 patients with non-ruptured intracranial aneurysms (control). Cerebrospinal fluid levels of these markers were determined using commercially available assay kits.

Results

Both trigeminal neuralgia and hemifacial spasm groups showed significantly increased cerebrospinal fluid levels of S100B compared with the control group (1120 [IQR 391–1420], 766 [IQR 583–1500], and 255 [IQR 190–285] pg/mL, respectively; p = 0.001). There were no statistically significant differences in cerebrospinal fluid levels of neuron-specific enolase or myelin basic protein among the groups.

Conclusion

Cerebrospinal fluid S100B levels were significantly higher in patients with trigeminal neuralgia and hemifacial spasm than in controls, which suggests the involvement of S100B in the underlying pathophysiology of neurovascular compression syndrome.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We wish to thank Dr. Akira Akabane, Dr. Masato Hara, Dr. Yuri Aimi, Dr. Tomoyuki Noda, and Dr. Yuji Endo for patient recruitment and data collection. The authors received no financial support for this research.

Funding

Open access funding was provided by Nagoya University Graduate School of Medicine.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-Ku, Nagoya, Aichi, 466-8560, Japan

    Eiji Ito & Ryuta Saito

  2. Department of Neurosurgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Aichi, Japan

    Yukio Seki

  3. Department of Neurosurgery, Fukushima Rosai Hospital, Iwaki, Fukushima, Japan

    Kiyoshi Saito

Authors
  1. Eiji Ito
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  2. Yukio Seki
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  3. Kiyoshi Saito
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  4. Ryuta Saito
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Contributions

Study design: Eiji Ito, Yukio Seki; data collection: Eiji Ito, Yukio Seki, Kiyoshi Saito; statistical analyses: Eiji Ito, Yukio Seki; manuscript writing and editing: Eiji Ito, Yukio Seki, Ryuta Saito.

Corresponding author

Correspondence to Eiji Ito.

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All procedures were conducted in accordance with the policies of the ethics committees of Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital (IRB No. 20110628–3).

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The authors declare no competing interests.

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Ito, E., Seki, Y., Saito, K. et al. Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm. Acta Neurochir 165, 959–965 (2023). https://doi.org/10.1007/s00701-022-05434-0

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  • DOI: https://doi.org/10.1007/s00701-022-05434-0

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