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Boron difluoride modified zinc metal–organic framework-based “off–on” fluorescence sensor for tetracycline and Al3+ detection

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Abstract

A novel fluorescence “off–on” probe was developed using a boron difluoride–modified zinc metal–organic framework (Zn-MOF3) for sensitive determination of tetracycline (TC) and Al3+. The Zn-MOF3 has excellent optical property and good applicability in aqueous phase. The fluorescence recorded at 436 nm was quenched at the excitation wavelength of 336 nm. Signal-off detection of tetracycline via fluorescence quenching of Zn-MOF3 is based on the inner filter effect. Fluorescence on–off-on detection of Al3+ occurs via the specific binding between tetracycline and Al3+. The limits of detection for TC and Al3+ were 28.4 nM and 106.7 nM, respectively. This probe exhibited high selectivity which was used for the determination of TC and Al3+ with satisfied recoveries (89.8 to 105.6% for TC, 90.0 to 110.4% for Al3+) and good precision (< 5%) in milk. The developed sensor represents the first “off–on” system for fluorescence detection of TC and Al3+ based on Zn-MOF3 with a better aspect of the innovation.

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Funding

This study was financially supported by the Opening Project of Medical Imaging Key Laboratory of Sichuan Province (No. MIKL202203), the Sichuan Provincial Students’ Innovation and Entrepreneurship Training Program (No. S202314389202), and the Scientific Research Innovation Team Funds of Chengdu Normal University (No. CSCXTD2020A05).

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Authors and Affiliations

  1. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu, 611130, China

    Qihui Wang, Haochen Du, Rui Tang, Xiaohui Wang, Lei Xie, Kang Sun, Zhonghui Li & Guowei Deng

  2. Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, 637000, Sichuan, China

    Jun Liu

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  1. Qihui Wang
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Contributions

Qihui Wang: data curation, methodology, investigation, and writing—original draft; Haochen Du, Rui Tang, Xiaohui Wang, and Lei Xie: data curation; Jun Liu: writing—review; Kang Sun: investigation and writing—review and editing; Zhonghui Li: funding acquisition and project administration; Guowei Deng: writing—review and editing, funding acquisition, and project administration.

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Wang, Q., Du, H., Tang, R. et al. Boron difluoride modified zinc metal–organic framework-based “off–on” fluorescence sensor for tetracycline and Al3+ detection. Microchim Acta 191, 144 (2024). https://doi.org/10.1007/s00604-024-06211-9

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