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A dual-channel sensor array for discrimination of biothiols based on manganese dioxide nanosheets

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Abstract

A dual-signal sensor array for highly sensitive identification of biothiols is reported based on different optical responses of MnO2/curcumin (CUR) system to different biothiols. The addition of MnO2 nanosheets (MnO2 NSs) quenches the fluorescence of CUR, and the color of the mixture changes from yellow to brown. In the presence of reductive biothiols, MnO2 NSs are etched and lose their fluorescence quenching ability, resulting in an increase in the fluorescence intensity of CUR at 540 nm and a decrease in the absorbance at 430 nm. The sensor array generates specific response modes based on the varying reduction abilities of different biothiols, which can be distinguished by linear discriminant analysis (LDA). The sensor array successfully distinguished five biothiols (glutathione (GSH), dithiothreitol (DTT), cysteine (Cys), mercaptoethanol (ME), and homocysteine (Hcy)) across a wide concentration range (1 μM-100 μM) and biothiol mixtures with varing molar ratios.

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Data sharing is not applicable to this manuscript as no new data were created or analyzed in this study.

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Acknowledgements

All authors gratefully acknowledge the financial support of Scientific Research Project of Beijing Educational Committee (KM202010028007), the Natural Science Foundation of China (52171157), and the Outstanding Youth Science Foundation Project of Henan Province (222300420063).

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Author notes

  1. Zhenni Qian, Chenyue Jiang and Chang Liu these authors contribute this work equally.

Authors and Affiliations

  1. Department of Chemistry, Capital Normal University, Beijing, 100048, China

    Zhenni Qian, Chenyue Jiang, Xinyu Liu, Xinyu Zhang, Kai Li & Zhengbo Chen

  2. College of Chemistry, University of California, CA, 94720, Berkeley, Berkeley, USA

    Chang Liu

  3. School of Mathematics and Physics, Anqing Normal University, Anqing, 246133, China

    Yumin Leng

Authors
  1. Zhenni Qian
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  2. Chenyue Jiang
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  3. Chang Liu
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  4. Xinyu Liu
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Correspondence to Yumin Leng, Kai Li or Zhengbo Chen.

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Qian, Z., Jiang, C., Liu, C. et al. A dual-channel sensor array for discrimination of biothiols based on manganese dioxide nanosheets. Microchim Acta 190, 294 (2023). https://doi.org/10.1007/s00604-023-05883-z

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