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Surface-enhanced Raman scattering based determination on sulfamethazine using molecularly imprinted polymers decorated with silver nanoparticles

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Abstract

Molecularly imprinted polymers (MIPs) were combined with surface-enhanced Raman scattering (SERS) and AgNPs were prepared by in situ reduction within the MIP for selective and sensitive detection of sulfamethazine (SMZ). The MIP@AgNPs composites were characterized in detail by several analytical techniques, showing the generation of polymers and the formation of AgNPs hot spots. The specific affinity and rapid adsorption equilibrium rates of MIP@AgNPs composites were verified by static and kinetic adsorption studies. The MIP@AgNPs with high selectivity and excellent sensitivity were used as SERS substrates to detect SMZ. A good linear correlation (R2 = 0.996) in rang of 10–10-10–6 mol L-1 was observed between the Raman signal (1596 cm−1) and the concentration of SMZ. The limit of detection (LOD) was as low as 8.10 × 10–11 mol L-1 with relative standard deviations (RSD) of 6.32%. The good stability and reproducibility are also fully reflected in the SERS detection based on MIP@AgNPs. The method was successfully applied to the analysis of lake water samples, with recoveries in the range 85.1% to 102.5%. In summary, SERS detection based on MIP@AgNPs can be developed for a wider and broader range of practical applications.

Graphical Abstract

Schematic illustration of MIP@AgNPs sensor for the SERS detection of sulfamethazine

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All data acquired or analyzed during this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This project was supported by the Innovation and Entrepreneurship Projects and Six Talent Peaks Project of Jiangsu Province (No. SWYY-023); F. P. thanks for the support from the National Natural Science Foundation of China (No. 21603087) and High-level Overseas Talent Workstation of Shandong Province.

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Author notes

  1. Guo-yong Jiang and Lin Liu are contributed equally to this work and shared first authorship.

Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China

    Guo-yong Jiang, Lin Liu, Yu-qi Wan, Jing-kun Li & Fu-wei Pi

  2. Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China

    Guo-yong Jiang, Lin Liu, Yu-qi Wan, Jing-kun Li & Fu-wei Pi

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  1. Guo-yong Jiang
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Correspondence to Fu-wei Pi.

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Jiang, Gy., Liu, L., Wan, Yq. et al. Surface-enhanced Raman scattering based determination on sulfamethazine using molecularly imprinted polymers decorated with silver nanoparticles. Microchim Acta 190, 169 (2023). https://doi.org/10.1007/s00604-023-05744-9

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