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Transarterial chemoembolization for liver metastases of a pancreatic neuroendocrine neoplasm: a single-center experience

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Abstract

Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1–6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4–6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14–41) and 27 (2–60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.

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Authors and Affiliations

  1. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Yoshihide Nanno, Hirochika Toyama, Jun Ishida, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Kaori Kuramitsu, Tadahiro Goto, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Tetsuo Ajiki & Takumi Fukumoto

  2. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

    Eisuke Ueshima & Keitaro Sofue

  3. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan

    Ippei Matsumoto

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  1. Yoshihide Nanno
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  2. Hirochika Toyama
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  15. Hiroaki Yanagimoto
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  18. Takumi Fukumoto
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Correspondence to Hirochika Toyama.

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Nanno, Y., Toyama, H., Ueshima, E. et al. Transarterial chemoembolization for liver metastases of a pancreatic neuroendocrine neoplasm: a single-center experience. Surg Today 53, 1396–1400 (2023). https://doi.org/10.1007/s00595-023-02714-9

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  • DOI: https://doi.org/10.1007/s00595-023-02714-9

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