Effects of high-intensity interval training on functional performance and maximal oxygen uptake in comparison with moderate intensity continuous training in cancer patients: a systematic review and meta-analysis

Introduction High-intensity interval training (HIIT) is an appropriate training modality to improve endurance and therefore contributes to physical performance. This review investigates the effect of HIIT on functional performance in cancer patients. We reviewed the relative peak oxygen uptake (relV̇O2PEAK) and meta-analytical compared HIIT with moderate intensity continuous training (MICT). Furthermore, we took various training parameters under consideration. Methods A systematic literature search was conducted in Scopus, PubMed, and Cochrane Library databases. For the review, we included randomized controlled trials containing HIIT with cancer patients. From this, we filtered interventions with additional MICT for the meta-analysis. Outcomes of interest were various functional performance assessments and V̇O2MAX. Results The research yielded 584 records which fit the inclusion criteria, of which 31 studies with n=1555 patients (57.4±8.6 years) could be included in the overall review and 8 studies in the meta-analysis (n=268, 59.11±5.11 years) regarding relV̇O2PEAK. Different functional outcomes were found, of which walking distance (+8.63±6.91% meters in 6-min walk test) and mobility (+2.7cm in sit and reach test) improved significantly due to HIIT. In terms of relV̇O2PEAK, the performance of cancer patients was improved by HIIT (10.68±6.48%) and MICT (7.4±4.29%). HIIT can be favored to increase relV̇O2PEAK (SMD 0.37; 95% CI 0.09–0.65; I2=0%; p=0.009). Effect sizes for relV̇O2PEAK improvements correlate moderately with total training volume (Spearman’s ρ=0.49; p=0.03), whereas percentage increases do not (Spearman’s ρ=0.24; p=0.14). Conclusion Functional and physical outcomes were positively altered by different HIIT protocols and forms of implementation, whereas a tendency toward more effectiveness of HIIT vs. MICT was found for relV̇O2PEAK. Future studies should include functional parameters more often, to finally allow a comparison between both training protocols in this regard. Supplementary Information The online version contains supplementary material available at 10.1007/s00520-023-08103-9.


Introduction
Adhering to common physical activity guidelines is considered an essential factor in prevention, treatment, and aftercare of various cancers [1], and has been shown to improve cancer-specific survival after treatments and all-cause mortality [2][3][4].Exercise as a planned, structured, and repetitive subset of physical activity [5] has been shown to contribute to both the prevention and management for several chronic diseases [6], including cancer [7].In addition to improved physical fitness and maintained activities of daily living, supervised physical training can make an impact on psychological well-being and consequently improve quality of life [7,8].Concomitant to medical treatment, exercise may be beneficial to reduce symptom experience (e.g., cancerrelated fatigue) and other therapy-related symptoms (e.g., from radiation and pharmaceuticals), and the risk of recurrence can be reduced [7,[9][10][11][12][13].
Cardiovascular diseases (CVD) share a number of risk factors with cancer [14].A study showed that CVD may be the primary cause of death in breast cancer survivors [15], 643 Page 2 of 30 an interesting finding that requires further evidence for other types of cancer.Studies show that cardiovascular training in cancer patients may be beneficial for multiple dimensions, such as physical function (e.g.VȮ 2 ), cancer-related fatigue, and functional capacity [16][17][18][19].This gives cardiovascular training (e.g., endurance exercise) a particular relevance for cancer survivors.Consistent with this, higher cardiorespiratory fitness has been associated with reduced cancer mortality [20].However, while individualized endurance training is recommended as a part of an optimally designed exercise program in cancer patients [21], there is still a lack of consensus as to which type of endurance exercise is most effective.Endurance exercise can be performed continuously with low to moderate intensity (MICT) or intermittently [22].High-intensity-interval training (HIIT) in particular, consisting of short, high-intensity training sessions (e.g., >80% maximal oxygen consumption [VȮ 2MAX ]) interspersed with low-intensity recovery phases [23,24] has gained interest not only in elite sports but also in the therapy of various diseases [25][26][27].Specific improvements were for example reduced dosage of medication and improved endurance performance in type 2 diabetes patients [25].HIIT was found to be significantly more effective than MICT to improve cardiac functions in myocardia infarct patients [26].
Milanović et al. [28] found a potentially large positive effect on VȮ 2MAX of +5.5±1.2 ml kg −1 min −1 after HIIT compared to healthy controls who did not exercise in young to middle-aged healthy individuals.Moreover, HIIT may have additional benefits as it induces alterations in peripheral muscle tissue (e.g.increased fiber cross sectional area and capillary-to-fiber ratio) that lead to a reduction in adverse effects of training, such as dyspnea and leg discomfort [29].In a comprehensive meta-analysis, Batacan et al. [30] report a significant improvement in VȮ 2MAX through HIIT in normal weight and overweight/obese populations, respectively.Furthermore, HIIT is a highly effective approach to improving cardiorespiratory fitness and quality of life in adults with chronic disease, especially in comparison with other forms of endurance training such as MICT [29,31,32].
As a result of early diagnosis and advanced treatment, cancer becomes a chronic disease for many people, with persistent side effects of therapy (e.g., loss of muscle mass and strength, loss of mobility and upper extremity disability, lymphedema, fatigue, and cardiac toxicity) [33].Functional performance can be impaired by muscle loss, limited upper and lower extremity strength, reduced walking distance, and various physical symptoms [34][35][36][37] from which an essential goal in the cancer aftercare is derived.
Studies indicate that HIIT is more beneficial than MICT for improving functional performance and sustaining those effects after detraining [38,39].HIIT can therefore be an efficient training regimen to promote functional performance [38].Superior effects of HIIT (vs.MICT) were also found for functional mobility in a healthy elderly population [39].The application of HIIT is acknowledged to be feasible and safe for cancer patients and can be an alternative to conventional endurance training to increase physical capacity [40][41][42].Due to the stated efficacy in terms of time, HIIT seems suitable for the supportive treatment of chronic diseases [43].
HIIT is a suitable form of training for a broad cancer patient population [42].HIIT can be performed by various types of cancer in UICC stages I-IV in prehabilitation (e.g., [44]), therapy (e.g., [45]), and aftercare (e.g., [46]).Nevertheless, a combination of HIIT and chemoradiation therapy can lead to an exacerbation of side effects and the subsequent reduction in quality of life [47].No substantial dropouts were reported even in a population with advanced cancer (stage IV) [48].High adherence was documented regarding perceived training sessions and targeted intensities [46,49].
While the positive effects of HIIT on physical fitness in cancer patients have been recognized [42], specific consideration of functional tests is lacking.Those outcomes could be essential to assess effects relevant to the everyday life of cancer survivors.In addition, HIIT protocols seem to be increasingly common in intervention studies from 2019 till now (total database records per year).Therefore, we performed a systematic literature review to analyze the functional performance following HIIT.We analyzed the effects of HIIT on maximal oxygen uptake (VȮ 2MAX ) and performed the meta-analytic approach comparing HIIT and MICT.In addition, we provide an overview of the specific features of the training programs used in the included studies.Based on the results of the review and meta-analysis, we aim to derive a possible preference regarding HIIT or MICT as a preferred training method in cancer patients.

Systematic literature search
The research was performed in line with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations [50].The search terms "cancer" AND "high intensity interval" were used for the systematic literature search.In March 2023, the PubMed, Scopus, and Cochrane Library databases were searched independently by two investigators using the specified search terms.In case of disagreement, a third reviewer was consulted.Information regarding the selection process is shown in the flow chart (Fig. 1).

Eligibility criteria
The eligibility criteria were based on the PICOS framework (population, intervention, comparison, outcome, study design).Studies with adult cancer patients of all types of cancer, stage, and sexes were included.The intervention had to consist solely of HIIT (any interval intensities, durations, and frequencies) over a period of at least 3 weeks, with a control group receiving only medical treatment (e.g., no exercise training, usual care) or another group performing any form of MICT.Considered outcomes were various practical functional assessments (e.g., 6-min walk test (6MWT), timed up and go test (TUG), sit to stand test (STS), sit and reach test (SRT), grip strength (GS), Margaria-Kalamen stair test (MKST), and chair stand test (CST)) and measurements for cardiorespiratory fitness (CRF) VȮ 2PEAK or VȮ 2MAX .We did not incorporate questionnaires, for instance on physical activity or self-assessments.Only randomized controlled trials (RCTs) with a pre-post design were included.

Data extraction
The following data were extracted: outcome parameter: functional assessments (e.g., 6MWT, sit to stand test, grip strength), measurements for CRF (relVO 2PEAK , VȮ 2MAX ).Outcomes were extracted from pre-and post-data of the studies.This was followed by converting the outcome data into the respective percentage change of the parameter.In the case of unspecific data areas (e.g., 70-85%), the respective mean value was used for further calculations.We calculated a total training volume by multiplying training weeks by training frequency per week and the duration of one session in minutes.
If available, data was extracted in terms of mean, standard deviation (SD), and sample size for meta-analysis.If certain data was missing [52][53][54], we contacted the respective author for further details.Data of Devin et al. (2016) [54] was received and included into the analysis.If specific data was not presented numerically [52,53], we extracted values from a figure by using the WebPlotDigitizer Tool [55].Due to different ways of presenting and analyzing results, studies with seemingly identical samples were still included (Table 1) [46,49,[56][57][58].To categorize interval durations, we set three groups, i.e., ≤1min, 1-3min, and ≥3min, based on the diversity of the available data.

Data synthesis and analysis
Only studies that analyzed a direct comparison of MICT and HIIT were included in the meta-analysis.Statistics, forest plot, and funnel plot were realized using RevMan (Review Manager Version 5.4,The Cochrane Collaboration, 2020) and IBM SPSS Statistics 29. Figure 4 was created using Grapher 12 (Golden Software).As all outcome measures were continuous variables, the intervention effects of each RCT were calculated using the standardized mean difference (SMD).A funnel plot was created to analyze symmetry and distribution for possible publication bias [59].
As the included RCTs differed in several aspects, the pooled effect size was calculated using the random-effects model, which is generally recommended [60] when heterogeneity between studies is assumed.The effect size of the change in VȮ 2PEAK /VȮ 2MAX (SMD) was calculated using the following equation [61]: x 1 and x 2 are the sample means in the two groups [61].The guideline values proposed by Cohen for the interpretation of the SMD are small (0.2), medium (0.5), and large (0.8) [62].
Heterogeneity between the included studies was assessed using the chi-square test and the I 2 statistic.The I 2 statistic determines the percentage of variability in the effect estimates that can be attributed to heterogeneity and can be interpreted as follows: 0-30% represents low heterogeneity, 30-60% represents moderate heterogeneity, and 60-100% represents high heterogeneity [63].By pooling the SD values, a more accurate estimate of their joint value was obtained.SD POOL was based on the SD from the baseline and the post values of the intervention group.
n 1 and n 2 are sample sizes of each group, whereas S 1 and S 2 are the standard deviations in the two groups.In some cases (e.g., [52]), no SD was available for pre-and/or post-values.Standard deviations were consequently calculated using the standard error (SE) or confidence interval (CI): Dividing the upper and lower limit of the CI by 3.92 was only used when a normal distribution could be assumed (e.g., large sample size) or was specifically reported.Otherwise, this value was based on a t-distribution (degrees of freedom −1, α = 0.05, two-tailed) [64].
The SE of the SMD is the square root of the variance (V D ) of the SMD [61]: Furthermore, we conducted a correlation analysis between the change in VȮ 2PEAK /VȮ 2MAX (% change, effect size (ES)) and the total exercise volume within the intervention group (HIIT).
Due to a violation of the assumption of normal distribution, a rank correlation (Spearman's rho (ρ)) was used and interpreted according to Cohen [62].As a positive correlation between the number of training sessions and VȮ 2PEAK was already shown [65], we hypothesized an improvement in VȮ 2PEAK /VȮ 2MAX and therefore performed a one-tailed correlation test.Statistical significance was assumed at p<0.05.

Study quality and risk of bias assessment
Study quality was assessed using the Tool for the assEssment of Study qualiTy and reporting in EXercise (TESTEX).TESTEX is a 15-point scale and includes 5 points for study quality and 10 points for study reporting.This assessment tool was specifically designed for use in exercise training studies.A high total score indicates high study quality [66].FITT and TESTEX have already been used in the context of cancer and exercise (e.g., [67]).
In addition, the revised Cochrane risk-of-bias tool [68] for randomized trials was used interdependently by two assessors to assess risk of bias.Five domains each relate to different aspects of bias: 1, randomization process; 2, deviations from the intended interventions; 3, missing outcome data; 4, outcome measurement; 5, selection of the reported outcome.To support the assessment of bias risk for the domain, the respective signal questions were answered and algorithms were followed to link the answers to the signal questions with suggestions for the resulting bias risk assessment [69].The evaluation results of the publications consulted and evaluated for this work are shown (Fig. 2).

Results
The literature search resulted in a total of 584 records.A total of 209 titles were not included due to duplication.The remaining 372 titles were screened with regard to title and abstract.After further exclusions, 31 publications were finally included in the review.Due to the lack of adequate study data, no meta-analysis could be performed regarding the functional outcome.Eight studies were included in the meta-analysis of relVȮ 2PEAK (Fig. 1).
Based on the risk of bias analysis, the included studies were not found to be high risk.Only domain 5 "Selection of the reported result" was ranked having "some concerns," as the relevant information could not be obtained from the available publications (Fig. 2).

Study population
A total of n=1555 patients aged 57.4±8.6 years were included in the review.A total of n=268 patients aged 59.11±5.11years were included in the meta-analysis.Cohorts with different cancer types (e.g., [71]) or a specific indication (e.g., prostate cancer [72]) were studied.The population varied between 16 and 151 cancer patients.The patients were at different diagnostic stages of cancer (UICC stages I-IV).When participating in the respective  [75], and ≤ years [71,76,77] elapsed after cancer diagnosis, respectively.In some cases, training was used preoperatively (e.g., cystectomy, lung resection, liver resection) [44, 56-58, 78, 79].In two studies, training was performed in-treatment, concomitantly to usual care, such as chemotherapy [45] or epidermal growth factor receptor inhibitor therapy [80].In one study, patients participated in the HIIT intervention within the aftercare period shortly after completing chemotherapy and radiotherapy [81].
Eight studies were analyzed for the effects of MICT versus HIIT on the increase in oxygen uptake [52-54, 74, 75, 77, 82, 89].The meta-analysis showed that HIIT had a small but significant main effect (SMD=0.37;CI 0.09-0.65;p=0.009).One study showed a preference toward the MICT method [75], while another [73] did not favor either form of training.The heterogeneity between the studies was I 2 = 0% (Fig. 3A).Due to its symmetry and data distribution, the funnel plot indicates no strong publication bias (Fig. 3B).Dolan et al. [73] had to be excluded from the meta-analysis because of missing baseline data (values were only presented for the entire population).Therefore, no specific effects for either HIIT or MICT could be calculated.

Training protocol and parameters
The duration of the training intervention was 8.0±3.6 weeks and varied between 2.5 and 12 weeks.Patients completed a mean of 3.0±0.4training sessions per week (Table 1).
Schmitt et al. [75] organized the training outside on an uphill road with short walking breaks between intervals.The interval training in Dolan et al. [73] started with lowintensity intervals (65-75% relVȮ 2PEAK ) for the first 2 weeks and increased progressively to 80-95% relVȮ 2PEAK .As the intensity increased, the duration of the intervals decreased from 4 to 2 min.

Discussion
The aim of this systematic review was to determine the effects of HIIT on the functional outcome and relVȮ 2PEAK in cancer patients.In addition, a meta-analytic approach compares HIIT vs. MICT regarding relVȮ 2PEAK .We also provide a detailed overview of implemented training parameters.

Functional outcomes
The functional outcomes walking distance (6MWT), mobility (SRT), grip strength (GS), and lower extremity strength (STS) were found in the reviewed studies.The data at hand suggest that an intervention with HIIT can significantly improve walking distance [56,58,71,76,83,85] and mobility [72] in cancer patients.When HIIT was performed with strength-oriented body weight exercises, grip strength improved twice as much compared to UC [84].This indicates that the method and manner HIIT is implemented may determine possible functional outcomes.It is plausible that GS would not be altered after HIIT, riding a stationary bike where no specific GS is required.In some cases, functional parameters such as TUG and STS remained almost unchanged following HIIT so that no differences from the control group can be observed [72,83].Toohey et al. [71,76] depicted opposing results for STS in a comparison between HIIT and MICT: In one study, the MICT group showed stronger improvements [76] whereas the another study [71] presents a stronger effect after HIIT.
The resulting walking distance can be used as a marker of aerobic fitness and as a protective factor for cancer mortality [90] and therefore is of great relevance.Accordingly, it is particularly significant for cancer patients to achieve practically relevant improvements in walking distance as a benefit of HIIT.Walking distance is also related to health status in cancer patients (quality of life, cancer-related symptoms) [91].In addition, the 6MWT could be used to plan and control training intensities, for example in the context of HIIT [92].The observed improvements [56,58,71,72,76,[83][84][85][86] exceeded the minimal clinically meaningful difference for multiple patient groups (including cancer survivors) of 14-30.5m[93] or 62.5m [94] improvements, respectively.Nevertheless, contrary results were also found for walking distance, HIIT resulted in marginal gains [87], and MICT resulted in greater improvement [53].
Due to lack of a specific comparison between HIIT and MICT, no meta-analysis for functional outcomes could be performed.Toohey et al. [71,76] presented 6MWT data for both training protocols that suggested a superiority of HIIT.We found more 6MWT [53,56,58,72,[83][84][85][86][87] and other functional outcomes [71,72,76,83,84], but none of these studies compared HIIT vs. MICT.Although specific evidences for cancer patients are limited, our meta-analytic data are in line with found differences between HIIT and MICT in healthy elder populations: Coswig et al. [38] found greater improvements in STS and 6MWT after HIIT (vs.MICT) in elderly women.Coetsee and Terblanche [39] presented greater functional improvements in TUG after HIIT (vs.MICT) in a healthy older population.Our results suggest that HIIT has the same tendency to improve functional performance, but further studies need to address the direct comparison between HIIT and MICT to verify these findings.
As shown in the meta-analysis, 7 out of 8 studies are presenting pronounced results after HIIT in terms of relVȮ 2PEAK (SMD 0.37; 95% CI 0.09 to 0.65; I 2 =0%; p=0.01); we can conclude superiority of the HIIT modality vs. MICT (Fig. 3).Mugele et al. [42] found no clear superiority of HIIT compared to MICT for relVȮ 2PEAK (MD 1.36; 95% CI −1.62 to 4.35; p=0.37).Due to a greater data source to evaluate this comparison, we conclude that HIIT may be more beneficial that MICT in order to improve relVȮ 2PEAK .Hooshmand-Moghadam et al. [52] also concluded that HIIT is more beneficial than MICT for improving physical fitness (here: relVȮ 2PEAK + low body strength).
Different methods to average peak values (e.g., over 20s or 30s) were used to determine relVȮ 2PEAK /VȮ 2MAX , which Page 25 of 30 643 limits the direct comparability of the data [95][96][97][98][99].The extent to which VȮ 2MAX can be achieved with in patients is debated [100,101].In many cases, a symptom-limited VȮ 2PEAK is assumed to be lower than the actual VȮ 2MAX [100].Most studies included in this review reported the relVȮ2peak.Of the reviews studies, only Alizadeh et al. [81] and Lee et al. [45] acclaimed having achieved a VȮ 2MAX .Alizadeh et al. [81] estimated the VȮ 2MAX using a submaximal test (Rockport 1 mile walk test) while Lee et al. [45] determined VȮ 2MAX using a ramp test on a cycling ergometer but did not provide information on criteria for workload.In general, when leveling off is reached, it is assumed that exhaustion and VȮ 2MAX are reached [98,100,101].Thus, it should be taken into account that, if necessary, patients did not reach a leveling off and relVȮ 2PEAK values were collected here.
When interpreting the aforementioned results, it should be noted that they only indirectly reflect the effects for the individual.It is therefore possible that the HIIT training protocol can achieve significantly higher, but also lower functional or physical effects in individual cases.Partially contradictory results are shown, for example, in the study by Boereboom et al. [102], in which individuals show strong positive changes in oxygen uptake, while others show negative changes.A clear attribution of cause (e.g., dependence on baseline level, number of training sessions performed) was not given.It is plausible that novice or, as in this case, deconditioned patients show significantly higher individual training effects than a person experienced in training [103].In some cases, novices without experience with intensive training [46,49] or inactive patients (did not achieve guideline recommendations for moderate or intensive activity) were explicitly included [71,78].

Training parameters and implementation
We stated that HIIT was performed on both the treadmill [46,49,72,76,80,81,88] or the cycling ergometer [44, 45, 48, 52-54, 56-58, 65, 71, 74, 76-80, 82, 83, 85, 86, 89].In two cases, training was performed by walking outdoors [73,75].Since running promotes greater muscle mass than cycling, the working muscle mass used differs between the "running" and "cycling" forms of exercise, limiting a direct comparison [104].HIIT on the treadmill was shown to result in higher heart rate and oxygen uptake than the same exercise on the cycling ergometer in healthy individuals [105].It is possible that the high-intensity loads outside (weather, ground conditions, elevation profile) compared to controlled laboratory conditions (treadmill, cycling ergometer) may have an impact on the target parameters.Two studies differed by applying home-based HIIT: Exercises were performed outside or at local training resources in various forms of endurance training [87] or using the patients' own body weight [84].
Schlüter et al. [107] compared 10×1min vs. 4×4min HIIT acutely protocols at 85-95% HR MAX (breast and prostate cancer patients) and concluded that a 4×4min protocol induced a higher energy expenditure and higher cardio-circulatory and metabolic strain.Therefore, if a high training stimulus is intended, a longer interval duration is preferable.However, an instructing physical therapist has to supervise if the patients tolerate rather long intervals, especially when undergoing therapy.Low training experience could also be a limiting factor in order to maintain intense intervals for several minutes.
A meta-analysis by Bacon et al. [108] showed that the design of the load factors during HIIT has an influence on the results in healthy individuals.It seems that especially the duration of the intervention in weeks is decisive.To take that into account, we included this parameter in total training volume.
A major criteria and possible promise of HIIT (compared with MICT) is generating relevant effects in a short time through short, intense intervals.Therefore, we analyzed the correlations between effects of HIIT on relVȮ 2PEAK and total training volume (Fig. 4).We are aware of possible confounding factors that have been considered with regard to the reliability of this statement, yet we selected a specific training parameter directly in the context of HIIT.The analysis indicates no direct dependence of total training volume and effects on relVȮ 2PEAK (Fig. 4).HIIT appears to be suitable for cancer patients to achieve relevant effects on endurance performance even in a short but intensive training period, although Lavín-Pérez et al. [109] point out that the exercise level should be at least 8 weeks, 2×/week (of which 15min HIIT/week) in cancer patients to achieve the highest return in healthrelated quality of life.In addition to intensity, it is possible that the total training volume represents a decisive Yet, every implementation of HIIT has to be depending on the individual physical capabilities which may be altered due to timing during therapy or aftercare respectively.Even though the data indicate that HIIT is beneficial and helpful in improving performance, it still represents an intensive form of endurance exercise, where the patient's health condition has a limiting effect on its applicability.A patient undergoing treatment may suffer from side effects, while the performance in aftercare may be impaired due to long-term cancer therapy and management.An individualized and supervised training regimen, in which specific training parameters can be modulated, could be key to implementing HIIT in prehabilitation, during treatment and aftercare as well.There is no specific red flag that excludes HIIT in any stage.A regression analysis of the influence of training volume and intensity could not be performed due to the partially imprecise or missing indications of the achieved training intensity (ranges from-to) (Table 1).As mentioned earlier, the study by Dolan et al. [73] was included even though the authors chose a progressive increase in intensity.This should be taken into account when interpreting the results and could be one reason why interval training was not superior to the continuous method in terms of relVȮ 2PEAK improvement, in contrast to other studies.
Based on this experimental application of the HIIT training form, insights for further therapeutic practice can be derived and aspects of the suitability and practical implementation of HIIT can be specified.In the context of endurance training in cancer patients, interval training can be used as a suitable, tolerable form of exercise.This is especially true, if a continuous load without breaks and over a longer period of time is not yet tolerated.HIIT is a suitable form of endurance training to improve cancerrelated fatigue [49,110].Taking into account the shorter "economic" training time, HIIT may be sufficient to contribute to the prevention of cardiovascular events or the reduction of cancer related fatigue.HIIT may thus represent an important contribution to improving physical fitness and health-related outcomes, and may add significant value compared to usual care [42].

Summary and outlook
The review showed that different functional outcomes were positively altered through HIIT.Our data indicates that HIIT might be more effective than MICT.Because functional outcomes were often not considered in the reviewed HIIT studies, no meta-analytic approach could be realized regarding the functional outcomes.We suggest that more attention should be paid to the functional outcome component to enable further direct comparisons between HIIT and MICT in terms of outcomes that are highly relevant to the daily lives of cancer survivors.
Furthermore, this review showed that positive changes in relVȮ 2PEAK were achieved with both MICT and HIIT, with HIIT usually having greater effects.Usual care alone mostly led to a decrease in performance.Results of the metaanalysis showed that HIIT appears to have greater effects on relVȮ 2PEAK compared to MICT.Further studies are needed to verify these results for relVȮ 2PEAK .
Precise information on frequency, duration, and intensity of the respective intervals cannot yet be given but could be optimized by the respective trainer in the future.Distinct relationships with various exercise factors (e.g., duration, intensity, frequency) have to be addressed in a targeted and systematic manner.Furthermore, the application of HIIT in the real clinical setting of cancer therapy should be verified.The present "black box" about how HIIT is implemented should be analyzed with concrete application-related data from clinical practice.

Fig. 1
Fig.1PRISMA flow chart to illustrate the selection of literature[70]

Fig. 3 Fig. 4
Fig. 3 Forest plot to compare HIIT and MICT regarding relVȮ 2PEAK (A) and funnel plot to evaluate publication bias (B)

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Page 26 of 30    parameter for training management of HIIT in cancer patients.

Table 1
Overview of included studies on the influence of HIIT training