Clinical risk factors for recurrence of pelvic organ prolapse after primary native tissue prolapse repair

Objective To define potential risk factors for recurrence of prolapse. Methods This short report included all women who presented with recurrence of prolapse as well as without any recurrence signs after a vaginal approach of native tissue prolapse repair at an urogynecological center in Austria. Results A total of 124 recurrence cases and 64 women with no signs of recurrence after their index prolapse surgery were included. Multivariate analysis identified advanced preoperative POP‑Q stage (pelvic organ prolapse-quantification) as an independent risk factor for postoperative recurrence of prolapse (p = 0.045). Conclusion Initial proper preoperative counseling is of particular importance to modulate patients’ expectations after prolapse surgery.


Introduction
Pelvic organ prolapse (POP) is defined as "falling or downward displacement of the uterus and/or the different vaginal compartments and their neighboring organs such as bladder, rectum or bowel" [1]. General known risk factors contributing to prolapse are childbirth, collagen abnormalities, increasing age, a chronic increase in intra-abdominal pressure and so on [2]. Treatment options include either pessary placement or surgical repair, whereas around 10% of women undergo prolapse surgery at some time in their lives [3]. The identification of risk factors for POP recurrence appears crucial for the best management of women with this condition. The objective of this study was to identify potential risk factors for prolapse recurrence after index surgery in a cohort of Austrian women.

Patients and methods
This short report includes 188 documented cases of patients who presented for follow-up after an index prolapse surgery at the department of general gynecology and gynecologic oncology, Medical University of Vienna (MUVI) with recruitment between March 2004 and October 2018. The study was approved by the ethics committee of Medical University of Vienna (EK No. 2186/2019).
Recurrence of prolapse was defined as follows: objective recurrence (prolapse reaching or going below the level of the hymen) or subjective recurrence (symptoms or wish for retreatment).
Planned index surgery included either vaginal hysterectomy with modified uterosacral ligament (USL) suspension as part of standard care for symptomatic POP or sacrospinous hysteropexy or transvaginal anterior/posterior repair (colporrhaphy) in cases of

Statistical analysis
The χ 2 -test was used for the comparison of categorical variables between the two groups and Student's ttest for continuous variables. Additional multivariate logistic regression analysis was conducted to evaluate the association of these clinical variables with postoperative prolapse recurrence. A p value < 0.05 was considered statistically significant. The SPSS system (IBM, Armonk, NY, USA, version 25) was used for the calculations.

Comparison between patients with and without recurrence
Chronic obstructive pulmonary disease (COPD) as well as postmenopausal status were factors that were statistically significantly more common in the recurrence group compared to patients without recurrence (p = 0.031; p = 0.001). Furthermore, women with recurrence were statistically significantly older and a diminished Oxford scale was observed (p = 0.001). The BMI, parity, mode of delivery, uterus preservation, smoking and hypertension did not differ between the two groups (p > 0.05).
Multiple logistic regression analysis was conducted in order to define independent risk factors for prolapse recurrence. Advanced POP-Q stage remained an independent risk factor for recurrence of prolapse postoperatively (Table 1).

Summary
In our opinion, the identification of risk factors for postoperative prolapse recurrence appears to be crucial and helps the clinician to divide patients into low-risk and high-risk recurrence cases with potential implications for treatment modalities. In the current study, initial advanced POP-Q stage was independently associated with prolapse recurrence. This information is important as it could help in clinical practice to counsel patients in an adequate way and to modulate patient's expectations. Ethical standards All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
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