Abstract
At present, evidence of the associations between carbon monoxide (CO) and respiratory diseases (RD) in Northwest China is limited and controversial. The aim of this study is to evaluate the impact of ambient CO on outpatient visits for RD in Lanzhou, China. The daily amount of outpatient visits for total and cause-specific RD, air pollutant, and weather variables were collected in Lanzhou, China from 1st January 2013 to 31st December 2019. A generalized additive model and distributed lag nonlinear model were used to assess associations between CO and outpatient visits for RD. During the study period, a total of 1,623,361 RD outpatient visits were recorded. For each interquartile range (IQR) (0.77 mg/m3) increase in CO, the relative risk (RR) was 1.163 (95% CI: 1.138, 1.188) for total RD at lag07, 1.153 (95% CI: 1.128,1.179) for upper respiratory tract infection (URTI) at lag07, 1.379 (95% CI: 1.338,1.422) for pneumonia at lag07, 1.029 (95% CI: 0.997,1.062) for chronic obstructive pulmonary disease (COPD) lag04, 1.068 (95% CI: 1.028,1.110) for asthma lag03, and 1.212 (95% CI: 1.178,1.247) for bronchitis lag07, respectively. In the subgroup analyses, the impacts of CO were more pronounced on total RD, pneumonia, COPD, and bronchitis in males than females, while the opposite was true in URTI and asthma. The impact of CO on RD was the strongest for children under 15 years-of-age. We also found significantly stronger effects during cold seasons compared to warm seasons. In addition, we observed a roughly linear exposure–response curve between CO and RD with no threshold effect. This study in Lanzhou revealed a remarkable association between CO level and an elevated risk of total and cause-specific RD outpatient visits, especially for pneumonia.
Similar content being viewed by others
Data availability
Not applicable.
Abbreviations
- CO:
-
Carbon monoxide
- RD:
-
Respiratory diseases
- URTI:
-
Upper respiratory tract infection
- COPD:
-
Chronic obstructive pulmonary disease
- GAM:
-
Generalized additive model
- DLNM:
-
Distributed lag nonlinear model
- PC:
-
Percentage change
- RR:
-
Relative risk
- Q-AIC:
-
Quasi-Akaike information criterion
- CI:
-
Confidence intervals
References
Capraz O, Deniz A, Dogan N (2017) Effects of air pollution on respiratory hospital admissions in Istanbul, Turkey, 2013 to 2015. Chemosphere 181:544–550. https://doi.org/10.1016/j.chemosphere.2017.04.105
Chang Q, Ye YJ, Wang QQ, Xue B, Ma XY, Ding Z, Zhou L, Chen XD (2017) Correlation between air pollutants and cardio-cerebrovascular mortality in Nanjing. J Environ Occup Med 34(12):1041–1045. https://doi.org/10.13213/j.cnki.jeom.2017.17433
Dong JY, Wang YR, Wang JC, Bao HR (2021a) Association between atmospheric PM2. 5 and daily outpatient visits for children’s respiratory diseases in Lanzhou. Int J Biometeorol 65(7):989–999. https://doi.org/10.1007/s00484-021-02080-6
Dong JY, Yang RQ, Zhai GY, Wang JC, Bao HR (2021b) Risks of hospital outpatient visits for overall and cause-specific respiratory disease associated with particulate matter pollution in Lanzhou. China Air Qual Atmos Health 14(9):1405–1415. https://doi.org/10.1007/s11869-021-01030-w
Filonchyk M, Yan HW (2018) The characteristics of air pollutants during different seasons in the urban area of Lanzhou, Northwest China. Environmental Earth Sciences 77(22):763. https://doi.org/10.1007/s12665-018-7925-1
Filonchyk M, Yan HW, Li XJ (2018) Temporal and spatial variation of particulate matter and its correlation with other criteria of air pollutants in Lanzhou, China, in spring-summer periods. Atmos Pollut Res 9(6):1100–1110. https://doi.org/10.1016/j.apr.2018.04.011
Gasparrini A (2011) Distributed lag linear and non-linear models in R: the package dlnm. J Stat Softw 43(8):1–20. https://doi.org/10.18637/jss.v043.i08
Guan WJ, Zheng XY, Chung KF, Zhong NS (2016) Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action. Lancet 388(10054):1939–1951
Guo XW, Song QX, Wang H, Li N, Su WY, Liang MM, Sun CY, Ding XX, Liang QW, Sun YH (2022) Systematic review and meta-analysis of studies between short-term exposure to ambient carbon monoxide and non-accidental, cardiovascular, and respiratory mortality in China. Environ Sci Pollut Res 29(24):35707–35722. https://doi.org/10.1007/s11356-022-19464-9
Hong Kong Special Administrative Region Government Census and Statistics Department (2022) Population Census Summary Results and Population Figures at end 2021. https://gia.info.gov.hk/general/202202/28/P2022022800453_388299_1_1646036881643.pdf. Accessed 13 May 2023
Jin LM, Zhou T, Fang SY, Zhou XW, Bai YN (2023) Association of air pollutants and hospital admissions for respiratory diseases in Lanzhou, China, 2014–2019. Environ Geochem Health 45(3):941–959. https://doi.org/10.1007/s10653-022-01256-2
Li HB, Wu JW, Wang AX, Li X, Chen SX, Wang TQ, Amsalu E, Gao Q, Luo YX, Yang XH, Wang W, Guo J, Guo YM, Guo XH (2018a) Effects of ambient carbon monoxide on daily hospitalizations for cardiovascular disease: a time-stratified case-crossover study of 460,938 cases in Beijing, China from 2013 to 2017. Environ Health 17(1):82. https://doi.org/10.1186/s12940-018-0429-3
Li R, Jiang N, Liu QC, Huang J, Guo XB, Liu F, Gao ZC (2017) Impact of Air Pollutants on Outpatient Visits for Acute Respiratory Outcomes. Int J Environ Res Public Health 14(1):E47. https://doi.org/10.3390/ijerph14010047
Li YR, Xiao CC, Li J, Tang J, Geng XY, Cui LJ, Zhai JX (2018b) Association between air pollution and upper respiratory tract infection in hospital outpatients aged 0–14 years in Hefei, China: a time series study. Public Health 156:92–100. https://doi.org/10.1016/j.puhe.2017.12.006
Liu C, Yin P, Chen RJ, Meng X, Wang LJ, Niu Y, Lin ZJ, Liu YN, Liu JM, Qi JL, You JL, Kan HD, Zhou MG (2018a) Ambient carbon monoxide and cardiovascular mortality: a nationwide time-series analysis in 272 cities in China. Lancet Planet Health 2(1):E12–E8. https://doi.org/10.1016/S2542-5196(17)30181-X
Liu H, Tian YH, Xiang X, Li M, Wu Y, Cao YY, Juan J, Song J, Wu T, Hu YH (2018b) Association of short-term exposure to ambient carbon monoxide with hospital admissions in China. Scientific Reports 8(1):13336. https://doi.org/10.1038/s41598-018-31434-1
Liu YR (2022) Study on the effect of air pollution on emergency room visits for respiratorydiseases in Lanzhou urban area. Dissertation (M.S.) Lanzhou University
Liu YW, Xie SG, Yu Q, Huo XX, Ming XY, Wang J, Zhou Y, Peng Z, Zhang H, Cui XQ, Xiang H, Huang XJ, Zhou T, Chen WH, Shi TM (2017) Short-term effects of ambient air pollution on pediatric outpatient visits for respiratory diseases in Yichang city, China. Environ Pollut 227:116–124. https://doi.org/10.1016/j.envPol.2017.04.029
Ma MJ, Chen Y, Ding F, Pu ZX, Liang XD (2019a) The representativeness of air quality monitoring sites in the urban areas of a mountainous city. J Meteorol Res 33(2):236–250. https://doi.org/10.1007/s13351-019-8145-7
Ma YX, Yang SX, Yu Z, Jiao HR, Zhang YF, Ma BJ (2019b) A study on the short-term impact of fine particulate matter pollution on the incidence of cardiovascular diseases in Beijing. China. Atmos Environ 215:116889. https://doi.org/10.1016/j.atmosenv.2019.116889
Ma YX, Zhao YX, Yang SX, Zhou JD, Xin JY, Wang SH, Yang DD (2017) Short-term effects of ambient air pollution on emergency room admissions due to cardiovascular causes in Beijing, China. Environ Pollut 230:974–980. https://doi.org/10.1016/j.envpol.2017.06.104
Ni Z, Liu B (2011) Respiratory basics and clinical. China Medical Science and Technology Press, Beijing
Niu CJ (2012) A study of family indoor environments and respiratory health of yound children. Dissertation (M.S.) Fudan University
Norazian MN, Shukri YA, Azam RN, Al Bakri AMM (2008) Estimation of missing values in air pollution data using single imputation techniques. ScienceAsia 34(3):341–345. https://doi.org/10.2306/scienceasia1513-1874.2008.34.341
Piantadosi CA (2008) Carbon monoxide, reactive oxygen signaling, and oxidative stress. Free Radical Biol Med 45(5):562–569. https://doi.org/10.1016/j.freeradbiomed.2008.05.013
Shanghai Municipal Bureau of Statistics (2021) Main Data Bulletin of the 7th National Census of Shanghai. https://tjj.sh.gov.cn/tjgb/20210517/cc22f48611f24627bc5ee2ae96ca56d4.html. Accessed 13 May 2023
Song JH, Qiu WH, Huang XZ, Guo Y, Chen WH, Wang DM, Zhang XK (2023) Association of ambient carbon monoxide exposure with hospitalization risk for respiratory diseases: A time series study in Ganzhou, China. Front Public Health 11:1106336. https://doi.org/10.3389/fpubh.2023.1106336
Sun CY, Zhao C, Cai JN, Zhang Y, Chen FG, Guan MY (2021) Time-series analysis of the association between gaseous pollutants and daily mortality of residents in Shijiazhuang China. J Environ Hyg 11(01):49–56. https://doi.org/10.13421/j.cnki.hjwsxzz.2021.01.010
Team RC (2014) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/. Accessed 15 Oct 2022
Teng J (2019) The short-term effects of air pollutants on hospitalizations for respiratory disease. Dissertation (M.S.) University of Science and Technology of China
Tian LW, Qiu H, Pun VC, Lin HL, Ge EJ, Chan JC, Louie PK, Ho KF, Yu ITS (2013) Ambient carbon monoxide associated with reduced risk of hospital admissions for respiratory tract infections. Am J Respir Crit Care Med 188(10):1240–1245. https://doi.org/10.1164/rccm.201304-0676OC
Wang QN, Chen Z, Huang W, Kou B, Li JW (2023) Short-Term Effect of Moderate Level Air Pollution on Outpatient Visits for Multiple Clinic Departments: A Time-Series Analysis in Xi’an China. Toxics 11(2):166. https://doi.org/10.3390/toxics11020166
Wang SS, Li YF, Niu AM, Liu Y, Su LL, Song WM, Liu JY, Liu YX, Li HC (2018) The impact of outdoor air pollutants on outpatient visits for respiratory diseases during 2012–2016 in Jinan. China. Respir Res 19(1):246. https://doi.org/10.1186/s12931-018-0958-x
Wang XY (2021) Analysis of the impact of ambient air pollution on hospitalizations for respiratory diseases and related economic losses in Wuhan, China. Dissertation (M.S.) Wuhan University
Wang Y, Yao CY, Xu CZ, Zeng XY, Zhou MG, Lin Y, Zhang P, Yin P (2019) Carbon monoxide and risk of outpatient visits due to cause-specific diseases: a time-series study in Yichang. China. Environ Health 18(1):36. https://doi.org/10.1186/s12940-019-0477-3
Wilson JL, Jesse HE, Poole RK, Davidge KS (2012) Antibacterial effects of carbon monoxide. Curr Pharm Biotechnol 13(6):760–768
Wood SN, Augustin NH (2002) GAMs with integrated model selection using penalized regression splines and applications to environmental modelling. Ecol Model 157(2–3):157–177. https://doi.org/10.1016/s0304-3800(02)00193-x
Wu TT, Yang XY, Chu AA, Xie XL, Bai M, Peng Y, Zhang Z (2022) Acute effects of fine particulate matter (PM2.5) on hospital admissions for cardiovascular diseases in Lanzhou, China: a time-series study. Environ Sci Eur 34(1):55. https://doi.org/10.1186/s12302-022-00634-y
Xiao QY, Liu Y, Mulholland JA, Russell AG, Darrow LA, Tolbert PE, Strickland MJ (2016) Pediatric emergency department visits and ambient Air pollution in the US State of Georgia: a case-crossover study. Environ Health 15(1):115. https://doi.org/10.1186/s12940-016-0196-y
Xu JX, Geng WF, Geng XY, Cui LJ, Ding T, Xiao CC, Zhang JQ, Tang J, Zhai JX (2020) Study on the association between ambient air pollution and daily cardiovascular death in Hefei China. Environ Sci Pollut Res 27(1):547–561. https://doi.org/10.1007/s11356-019-06867-4
Yang QY, Chen Y, Krewski D, Burnett RT, Shi YL, McGrail KM (2005) Effect of short-term exposure to low levels of gaseous pollutants on chronic obstructive pulmonary disease hospitalizations. Environ Res 99(1):99–105. https://doi.org/10.1016/j.envres.2004.09.014
Yu HL, Yang CH, Chien LC (2013) Spatial vulnerability under extreme events: a case of Asian dust storm’s effects on children’s respiratory health. Environ Int 54:35–44. https://doi.org/10.1016/j.envint.2013.01.004
Zayasu K, Sekizawa K, Okinaga S, Yamaya M, Ohrui T, Sasaki H (1997) Increased carbon monoxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 156(4):1140–1143. https://doi.org/10.1164/ajrccm.156.4.96-08056
Zhang H, Niu Y, Yao YL, Chen RJ, Zhou XH, Kan HD (2018) The impact of ambient air pollution on daily hospital visits for various respiratory diseases and the relevant medical expenditures in Shanghai, China. Int J Environ Res Public Health 15(3):425. https://doi.org/10.3390/ijerph15030425
Zhang LL (2017) Research on the association of ambient air pollution and acute attack of respiratory and circulatory system diseases in the urban area of Changchun. Dissertation (M.S.) Jilin University
Zhao SP, Yu Y, Qin DH (2018) From highly polluted inland city of China to “Lanzhou Blue”: the air-pollution characteristics. Sci Cold Arid Reg 10(1):12–26. https://doi.org/10.3724/sp.J.1226.2018.00012
Zhao YJ, Hu JX, Tan ZW, Liu T, Zeng WL, Li X, Huang CY, Wang SY, Huang Z, Ma WJ (2019) Ambient carbon monoxide and increased risk of daily hospital outpatient visits for respiratory diseases in Dongguan, China. Sci Total Environ 668:254–260. https://doi.org/10.1016/j.scitotenv.2019.02.333
Zhu L (2015) Time series analysis on association between air pollution and outpatient visits for respiratory diseases of pediatric in a hospital in Hefei. Dissertation (M.S.) Anhui Medical University
Acknowledgements
The authors acknowledge the dedication and cooperation of all the participants in this study.
Funding
This research was supported by the National Natural Science Foundation of China (72264002), the Fundamental Research Funds for the Central Universities, Lanzhou University, China (lzujbky-2022–44), and this research was supported by Gansu key research and development program under Grant No.23YFFA0033.
Author information
Authors and Affiliations
Contributions
Jiancheng Wang and Hairong Bao contributed to the conception or design of the work. Jianhua You, Yaocong Liu, and Jiyuan Dong are major contributors in writing the manuscript.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
The present study is considered exempt from institutional review board approval since the data used was collected for administrative purpose without any personal identifiers.
Consent for publication
Not applicable.
Conflict of interest
The authors declare no competing interests.
Additional information
Yaocong Liu and Jiyuan Dong are the co-first authors.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Liu, Y., You, J., Dong, J. et al. Ambient carbon monoxide and relative risk of daily hospital outpatient visits for respiratory diseases in Lanzhou, China. Int J Biometeorol 67, 1913–1925 (2023). https://doi.org/10.1007/s00484-023-02550-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00484-023-02550-z