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Advances in understanding effects of miRNAs on apoptosis, autophagy, and pyroptosis in knee osteoarthritis

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A Correction to this article was published on 28 January 2024

This article has been updated

Abstract

MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs. MicroRNAs-mediated signaling pathways play a critical regulatory role in inducing apoptosis, autophagy, and pyroptosis in developing knee osteoarthritis (KOA). Given this, we searched databases, such as PubMed, using keywords including “miRNA,” “knee osteoarthritis,” “apoptosis,” “autophagy,” “pyroptosis”, and their combinations. Through an extensive literature review, we conclude that miRNAs can be modulated through various signaling pathways, such as Wnt/β-catenin, TGF-β, PI3K/AKT/mTOR, and NLRP3/Caspase-1, to regulate apoptosis, autophagy, and pyroptosis in KOA. Furthermore, we note that P2X7R and HMGB1 may be crucial regulatory molecules involved in the interconnected regulation of apoptosis, autophagy, and pyroptosis in KOA. Additionally, we describe that miR-140-5p and miR-107 can modulate the advancement of KOA chondrocytes by targeting distinct molecules involved in apoptosis, autophagy, and pyroptosis, respectively. Therefore, we conclude that miRNAs may be potential biomarkers and therapeutic targets for the early prediction, diagnosis, and effective therapeutic approaches of KOA.

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Change history

  • 01 January 2024

    The original online version of this article was revised to denote Fangyu An and Bai Sun contributed equally to the article.

  • 28 January 2024

    A Correction to this paper has been published: https://doi.org/10.1007/s00438-023-02092-4

Abbreviations

KOA:

Knee osteoarthritis

miRNA:

MicroRNA

ER:

Endoplasmic reticulum

NLRP3:

NOD-like receptor protein 3

Caspase:

Cysteine aspartate-containing protein hydrolase

IL:

Interleukin

ECM:

Extracellular matrix

MMPs:

Matrix metalloproteinases

NO:

Nitric oxide

LPS:

Lipopolysaccharide

NSAIDs:

Nonsteroidal anti-inflammatory drugs

PACT:

Protein Activator of PKR

AGO:

Argonaute

nt:

Nucleotide

mRNA:

Messenger RNA

DR:

Death receptor

FASL:

Fas Ligand

DISC:

Death-inducing signaling complex

FADD:

Fas-associated protein with death domain

DED:

Death effector structural domain

MOMP:

Mitochondrial outer membrane permeabilization

cyt-C:

Cytochrome C

APAF-1:

Apoptotic protease activating factor 1

Bcl-2:

B cell lymphoma-2 gene

TNF:

Tumor necrosis factor

ROS:

Reactive oxygen species

TGF-β:

Transforming growth factor-β

PI3K:

Phosphatidylinositol-3-kinase

DVL:

Disheveled

CTSB:

Cathepsin B

GSK-3β:

Glycogen synthase kinase-3β

CK1:

Casein kinase I

NEK2:

NIMA-related kinase 2

LncRNAs:

Long noncoding RNAs

FUT2:

Fucosyltransferase 2

VEGF:

Vascular endothelial growth factor

IGF-1:

Insulin-like growth factor 1

FLS:

Fibroblast-like synoviocytes

ATP:

Adenosine triphosphate

HMGB1:

High mobility group box-1

CTSB:

Cathepsin B

P2X7R:

P2X7 purinergic receptor

FUT1:

Fucosyltransferase 1

TRAF3:

TNF receptor-associated factor 3

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Acknowledgments

This article was funded by the grants from Natural Science Program in Gansu Province (20JR5RA185), Scientific Research Program of Gansu Chinese Medicine Bureau (GZKP-2021-34), the Young Doctor Fund Program of Colleges and Universities in Gansu Province (2022QB-091). We also would like to thank textcheck (www.textcheck.com) for English language editing.

Funding

This article was funded by the grants from Natural Science Program in Gansu Province (20JR5RA185), Scientific Research Program of Gansu Chinese Medicine Bureau (GZKP-2021-34), the Young Doctor Fund Program of Colleges and Universities in Gansu Province (2022QB-091), Innovation Fund Project of Higher Education Institutions in Gansu Provincial (2022A-072).

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  1. Fangyu An and Bai Sun have contributed equally to this work.

Authors and Affiliations

  1. Teaching Experiment Training Center, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, China

    Fangyu An

  2. School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, China

    Bai Sun, Xiaxia Wang, Jiayu Wang & Chunlu Yan

  3. School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, China

    Ying Liu, Chunmei Wang & Yongqi Liu

  4. Research Center of Traditional Chinese Medicine of Gansu, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, China

    Chunlu Yan

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  1. Fangyu An
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Contributions

FA and BS were responsible for the collection, analysis of the references, and wrote the manuscript. YL and CY contributed to the conception of the study, the submission, and the revision of the manuscript. YL, CW, XW, and JW helped in drawing the figures of the manuscript and checking the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Yongqi Liu or Chunlu Yan.

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An, F., Sun, B., Liu, Y. et al. Advances in understanding effects of miRNAs on apoptosis, autophagy, and pyroptosis in knee osteoarthritis. Mol Genet Genomics 298, 1261–1278 (2023). https://doi.org/10.1007/s00438-023-02077-3

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