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Study on the preoperative value of serum SCC-Ag in predicting the stromal invasion of cervical squamous cell carcinoma

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Abstract

Objective

To investigate the preoperative value of serum SCC-Ag in predicting the stromal invasion of cervical squamous cell carcinoma.

Methods

This study retrospectively analyzed 78 patients with early cervical squamous cell carcinoma who underwent surgery as initial treatment at the Senior Department of Obstetrics and Gynecology, the Seventh Medical Center of PLA General Hospital from January 2018 to September 2022 was implemented. The clinicopathological characteristics were statistically compared. The ROC curve was drawn to determine the optimal critical level of  preoperative serum SCC-Ag value for predicting cervical stromal invasion.

Results

The depth of myometrial invasion was not related to the age of diagnosis and HPV infection (p > 0.05), while it was related to tumor size, staging, tissue differentiation, LVSI, lymph node metastasis (LNM) and preoperative serum SCC-Ag value (p < 0.05).The area under the curve (AUC) of serum SCC-Ag value was 0.894 (p = 0.000, 95% CI 0.824–0.964), and preoperative serum SCC-Ag value 1.65 ng/ml was the best cutoff for predicting cervical stromal invasion in cervical squamous cell carcinoma. The sensitivity and specificity of diagnosis were 92.3% and 78.8%, respectively.

Conclusion

If the preoperative serum SCC-Ag leval more than 1.65 ng/ml in patients with cervical squamous cell carcinoma, the risk of cervical stromal invasion will increase, which can provide a reference for clinical treatment.

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Data availability

The datasets of this study are available from the corresponding author on reasonable request.

References

  • Aviel-Ronen S, Rubinek T, Zadok O, Vituri A, Avivi C, Wolf I et al (2016) Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma. J Clin Pathol 69(1):53–57

    Article  CAS  PubMed  Google Scholar 

  • Beharee N, Shi Z, Wu D, Wang J (2019) Diagnosis and treatment of cervical cancer in pregnant women. Cancer Med 8(12):5425–5430

    Article  PubMed  PubMed Central  Google Scholar 

  • Choi KH, Lee SW, Yu M, Jeong S, Lee JW, Lee JH (2019) Significance of elevated SCC-Ag level on tumor recurrence and patient survival in patients with squamous-cell carcinoma of uterine cervix following definitive chemoradiotherapy: a multi-institutional analysis. J Gynecol Oncol 30(1):e1

    Article  CAS  PubMed  Google Scholar 

  • Gülseren V, Kocaer M, Çakır İ, Özdemir İA, Sancı M, Güngördük K et al (2020) Postoperative nomogram for the prediction of disease-free survival in lymph node-negative stage I-IIA cervical cancer patients treated with radical hysterectomy. Obstet Gynaecol 40(5):699–704

    Article  Google Scholar 

  • Jeong BK, Huh SJ, Choi DH, Park W, Bae DS, Kim BG (2013) Prognostic value of different patterns of squamous cell carcinoma antigen level for the recurrent cervical cancer. Cancer Res Treat 45(1):48–54

    Article  PubMed  PubMed Central  Google Scholar 

  • Jo EB, Lee YS, Lee H, Park JB, Park H, Choi YL et al (2019) Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells. BMC Cancer 19(1):496

    Article  PubMed  PubMed Central  Google Scholar 

  • Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Cho KR et al (2015) Cervical cancer, version 2.2015. J Natl Compr Canc Netw 13(4):395–404

    Article  CAS  PubMed  Google Scholar 

  • Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR et al (2018) Uterine neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 16(2):170–199

    Article  PubMed  Google Scholar 

  • Kubota S, Kobayashi E, Kakuda M, Matsuzaki S, Ueda Y, Yoshino K et al (2019) Retrospective analysis for predictors of parametrial involvement in IB cervical cancer. J Obstet Gynaecol Res 45(3):679–685

    Article  PubMed  Google Scholar 

  • Li D, Cai J, Kuang Y, Cao J, Wang Z (2012) Surgical-pathologic risk factors of pelvic lymph node metastasis in stage Ib1–IIb cervical cancer. Acta Obstet Gynecol Scand 91(7):802–809

    Article  PubMed  Google Scholar 

  • Li D, Xu XX, Yan DD, Yuan SH, Lou HM (2019) Clinical significance of serum squamous cell carcinoma antigen in patients with early cervical squamous cell carcinoma. Zhonghua Zhong Liu Za Zhi 41(5):357–362

    CAS  PubMed  Google Scholar 

  • Mongula JE, Slangen BF, Lambregts DM, Cellini F, Bakers FC, Lutgens LC et al (2015) Consecutive magnetic resonance imaging during brachytherapy for cervical carcinoma: predictive value of volume measurements with respect to persistent disease and prognosis. Radiat Oncol 10:252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nagai Y, Toma T, Moromizato H, Maehama T, Asato T, Kariya K et al (2004) Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy. Am J Obstet Gynecol 191(6):1907–1913

    Article  PubMed  Google Scholar 

  • Oh J, Lee HJ, Lee TS, Kim JH, Koh SB, Choi YS (2016) Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with locally advanced cervical cancer treated with radiation or chemoradiation. Obstet Gynecol Sci 59(4):269–278

    Article  PubMed  PubMed Central  Google Scholar 

  • Scurry J, Hacker NF, Barlow E, Friedlander M, Jackson M (2015) Is quantification of lymphovascular space invasion useful in stage 1B2 cervical carcinomas? J Obstet Gynaecol 35(4):377–381

    Article  CAS  PubMed  Google Scholar 

  • Shimura K, Mabuchi S, Yokoi T, Sasano T, Sawada K, Hamasaki T et al (2013) Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice. J Gynecol Oncol 24(4):321–329

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sookha RR, Zhi W, Shen Y, Lazare C, Wang L, Meng Y et al (2018) Clinical value of combining (18)F-FDG PET/CT and routine serum tumor markers in the early detection of recurrence among follow-up patients treated for cervical squamous cell carcinoma. J Cancer 9(17):3101–3108

    Article  PubMed  PubMed Central  Google Scholar 

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249

    Article  PubMed  Google Scholar 

  • Xu D, Wang D, Wang S, Tian Y, Long Z, Ren X (2017) Correlation between squamous cell carcinoma antigen level and the clinicopathological features of early-stage cervical squamous cell carcinoma and the predictive value of squamous cell carcinoma antigen combined with computed tomography scan for lymph node metastasis. Int J Gynecol Cancer 27(9):1935–1942

    Article  PubMed  Google Scholar 

  • Yan W, Qiu S, Ding Y, Zhang Q, Si L, Lv S et al (2019) Prognostic value of lymphovascular space invasion in patients with early stage cervical cancer in Jilin, China: a retrospective study. Medicine (baltimore) 98(40):e17301

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, Ou J, Lei F, Hou T, Wu S, Niu C et al (2016) C14ORF166 overexpression is associated with pelvic lymph node metastasis and poor prognosis in uterine cervical cancer. Tumour Biol 37(1):369–379

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Senior Department of Obstetrics & Gynecology, The Seventh Medical Center of PLA General Hospital, Beijing, China

    Lin Qin

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  1. Lin Qin
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The author contributed to the concept and design of the study, analyzed and interpreted the data, revised and approved the final version of the manuscript.

Corresponding author

Correspondence to Lin Qin.

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The author has no conflicts of interest to declare.

Ethics approval

This study was approved by the ethics committees of Senior Department of Obstetrics and Gynecology of PLA General Hospital, with approval no 2022KY122-KS001, and was conducted in accordance with the Declaration of Helsinki.

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Qin, L. Study on the preoperative value of serum SCC-Ag in predicting the stromal invasion of cervical squamous cell carcinoma. J Cancer Res Clin Oncol 149, 9167–9171 (2023). https://doi.org/10.1007/s00432-023-04836-6

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