Abstract
Percutaneous catheter-based closure is increasingly utilized in premature newborns. While near-infrared spectroscopy (NIRS) has been examined for assessment of interventional closure in surgical ligation, its application in percutaneous transcatheter closure remains unexplored. This study aims to assess cerebral and renal hemodynamic changes using NIRS during percutaneous closure compared to surgical closure in preterm infants. A prospective observational study enrolled preterm infants born at 32 weeks of gestation or less and diagnosed with hsPDA between January 2020 and December 2022. These infants received either surgical or catheter-based closure of the PDA. Cerebral and renal oxygen saturation was monitored using the INVOS 5100 device from 12 h before the intervention until 24 h after. Linear mixed-effects models were used to analyze time-dependent variables. Twenty-two patients were enrolled, with catheter-based closure performed in 16 cases and conventional surgery in 6 cases. Following ductal closure, a significant increase in renal and cerebral oximetry was observed alongside a decrease in renal and cerebral tissue oxygen extraction. These changes were particularly pronounced in the renal territory. No differences were detected between catheterization and surgical closure.
Conclusion: An improvement in cerebral and renal oximetry following hsPDA closure was observed. However, we did not identify differences in this pattern based on the type of interventional procedure for PDA, whether surgery or catheterization.
What is Known: • The presence of a significant ductus is common in premature patients. Studies have shown that it affects cerebral and renal hemodynamics negatively, leading to decreased oximetry values in these areas. It has been reported that closure of the ductus, either pharmacologically or surgically, results in improved oximetry values. | |
What is New: • This study assess the impact of percutaneous closure of ductus, revealing increased oximetry values in cerebral and renal territories without significant differences compared to surgical ligation. Notably, renal oximetry values showed a greater increase, underscoring the importance of multi-location monitoring. |
Similar content being viewed by others
Data availability
No datasets were generated or analysed during the current study.
Code availability
Not applicable
References
Conrad C, Newberry D (2019) Understanding the pathophysiology, implications, and treatment options of patent ductus arteriosus in the neonatal population. Adv Neonatal Care: Official J Natl Assoc Neonatal Nurs 19(3):179–187
Almeida-Jones M, Tang NY, Reddy A, Zahn E (2019) Overview of transcatheter patent ductus arteriosus closure in preterm infants. Congenit Heart Dis 14(1):60–64
Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J et al (2020) Patent ductus arteriosus of the preterm infant. Pediatrics 146(5):e20201209
Navikiene J, Virsilas E, Vankeviciene R, Liubsys A, Jankauskiene A (2021) Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study. BMC Pediatr 21(1):559
Mitra S, McNamara PJ (2020) Patent ductus arteriosus-time for a definitive trial. Clin Perinatol 47(3):617–639
Lemmers PM, Toet MC, van Bel F (2008) Impact of patent ductus arteriosus and subsequent therapy with indomethacin on cerebral oxygenation in preterm infants. Pediatrics 121(1):142–147
Lemmers PM, Molenschot MC, Evens J, Toet MC, van Bel F (2010) Is cerebral oxygen supply compromised in preterm infants undergoing surgical closure for patent ductus arteriosus? Archives of disease in childhood fetal and neonatal edition. 95(6):F429–F434
Chock VY, Rose LA, Mante JV, Punn R (2016) Near-infrared spectroscopy for detection of a significant patent ductus arteriosus. Pediatr Res 80(5):675–680
Cohen E, Dix L, Baerts W, Alderliesten T, Lemmers P, van Bel F (2017) Reduction in cerebral oxygenation due to patent ductus arteriosus is pronounced in small-for-gestational-age neonates. Neonatology 111(2):126–132
Zaramella P, Freato F, Quaresima V, Ferrari M, Bartocci M, Rubino M et al (2006) Surgical closure of patent ductus arteriosus reduces the cerebral tissue oxygenation index in preterm infants: a near-infrared spectroscopy and Doppler study. Pediatr Int 48(3):305–312
Vanderhaegen J, De Smet D, Meyns B, Van De Velde M, Van Huffel S, Naulaers G (2008) Surgical closure of the patent ductus arteriosus and its effect on the cerebral tissue oxygenation. Acta Paediatr 97(12):1640–1644
Chock VY, Ramamoorthy C, Van Meurs KP (2011) Cerebral oxygenation during different treatment strategies for a patent ductus arteriosus. Neonatology 100(3):233–240
Underwood MA, Milstein JM, Sherman MP (2007) Near-infrared spectroscopy as a screening tool for patent ductus arteriosus in extremely low birth weight infants. Neonatology 91(2):134–139
Ledo A, Aguar M, Nunez-Ramiro A, Saenz P, Vento M (2017) Abdominal near-infrared spectroscopy detects low mesenteric perfusion early in preterm infants with hemodynamic significant ductus arteriosus. Neonatology 112(3):238–245
Borysova TP, Surkov DM, Obolonska OY, Obolonskiy AI (2021) Condition of renal oxygenation in preterm infants with hemodinamically significant patent ductus arteriosus. Wiad Lek 74(10 pt 1):2379–2383
Petrova A, Mehta R (2006) Near-infrared spectroscopy in the detection of regional tissue oxygenation during hypoxic events in preterm infants undergoing critical care. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and. Crit Care Soc 7(5):449–454
Tina LG, Frigiola A, Abella R, Tagliabue P, Ventura L, Paterlini G et al (2010) S100B protein and near infrared spectroscopy in preterm and term newborns. Front Biosci 2(1):159–164
McNeill S, Gatenby JC, McElroy S, Engelhardt B (2011) Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infants. J Perinatol: Official J Calif Perinat Assoc 31(1):51–57
Schuurmans J, Benders M, Lemmers P, van Bel F (2015) Neonatal morphine in extremely and very preterm neonates: its effect on the developing brain-a review. The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet 28(2):222–228
Beltran-Campos V, Silva-Vera M, Garcia-Campos ML, Diaz-Cintra S (2015) Effects of morphine on brain plasticity. Neurologia 30(3):176–180
Funding
This study received funding through a research grant from the Spanish Society of Neonatology.
Author information
Authors and Affiliations
Contributions
Conceptualization: M.A.R, A.R.S.B, A.R.O; methodology MAR, ARSB; validation MSL, JLZ, FB, DBB; formal analysis MAR, PGN; investigation MAR, ARSB; writing—original draft preparation MAR; review and supervision MSL, DBB, JLZ, ARSB, FB, ARO. All authors have read and agreed to the published version of the manuscript.
Corresponding author
Ethics declarations
Ethics approval
This study has been conducted in accordance with the Declaration of Helsinki and following the Spanish law (Ley Orgánica de protección de datos 3/2018). This study was approved by the ethics committee of the hospital: Comité de Ética de la Investigación con Medicamentos Hospital General Universitario Gregorio Marañón (Committee for Research Ethics in Medicine Research Hospital General Universitario Gregorio Marañón)
Consent to participate
Informed consent was obtained from parents.
Competing interests
The authors declare no competing interests.
Additional information
Communicated by Daniele De Luca
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Arriaga-Redondo, M., Rodríguez-Sánchez de la Blanca, A., Zunzunegui, J.L. et al. Impact of catheterized ductal closure on renal and cerebral oximetry in premature neonates. Eur J Pediatr 183, 2753–2761 (2024). https://doi.org/10.1007/s00431-024-05541-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00431-024-05541-3