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Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease

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Abstract

Kawasaki disease (KD) is an acute vasculitis of childhood that predominantly affects the coronary arteries. We investigated single nucleotide polymorphisms (SNPs) of the tryptophan hydroxylase 2 (TPH2) gene as risk factors for KD with coronary artery lesions (CALs) in Korean children. We genotyped two SNPs [rs7305115 (exon 7) and rs4290270 (exon 9)] using direct sequencing in 101 KD and 256 control subjects. To analyze the genetic data, SNPStats, SNPAnalyzer, and Helixtree programs were used. The genotype analysis of rs7305115 and rs4290270 showed no significant differences between KD and control groups. However, we found a statistically significant association between the two SNPs and the development of CALs in KD (p < 0.05). The minor homozygous genotype (rs7305115, AA genotype and rs42901270, AA genotype) of each SNP showed increased susceptibility to risk of CALs in KD patients. These results suggest that TPH2 may be associated with the development of KD with CALs in Korean children.

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Abbreviations

TPH2:

Tryptophan hydroxylase 2

KD:

Kawasaki disease

CALs:

Coronary artery lesions

SNP:

Single nucleotide polymorphism

IVIG:

Intravenous immunoglobulin

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Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

    Sung Wook Park, Jun Young Chung, Jae Woo Yi & Bong Jae Lee

  2. Department of Pharmacology, College of Dentistry, Dankook University, Cheonan-si, Chungnam, Republic of Korea

    Ju Yeon Ban

  3. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul, 130701, Republic of Korea

    Hak Jae Kim & Joo-Ho Chung

  4. Department of Pediatrics, East–West Neo Medical Center, Kyung Hee University, Seoul, Republic of Korea

    Kyung Lim Yoon

Authors
  1. Sung Wook Park
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  2. Ju Yeon Ban
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  3. Kyung Lim Yoon
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  4. Hak Jae Kim
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  5. Jun Young Chung
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  6. Jae Woo Yi
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  7. Bong Jae Lee
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  8. Joo-Ho Chung
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Correspondence to Joo-Ho Chung.

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Park, S.W., Ban, J.Y., Yoon, K.L. et al. Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease. Eur J Pediatr 169, 457–461 (2010). https://doi.org/10.1007/s00431-009-1056-3

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  • DOI: https://doi.org/10.1007/s00431-009-1056-3

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