Abstract
Neuroendocrine neoplasms of the urinary bladder are uncommon tumors represented by small-cell neuroendocrine carcinoma and by fewer cases of large-cell neuroendocrine carcinomas and well-differentiated neuroendocrine tumors. Less than 30 examples of this latter entity have been published so far and consisted of clinically indolent lesions mainly located in the bladder neck arranged in a pseudo-glandular architecture often associated with reactive urothelial changes like cystitis cystica/glandularis. Due to their infrequency, pathologists may face difficulty to recognize this proliferation considering it as part of cystitis cystica/glandularis or misinterpreting it as nested urothelial carcinoma, paraganglioma, or secondary bladder involvement by prostatic adenocarcinoma. Herein the case of a 51-year-old female diagnosed with a well-differentiated neuroendocrine tumor of the bladder immunohistochemically expressing GATA3 is reported, pointing out either the pitfall in the differential diagnosis with cystitis cystica/glandularis, nested urothelial carcinoma, and paraganglioma or its usefulness in the differential diagnosis with prostatic adenocarcinoma.
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Conceptualization: A.C. and G.M.; methodology: S.M. and A.C.; formal analysis and investigation: S.M. and G.M.; writing—original draft preparation: S.M. and A.C.; writing—review and editing: C.G., L.S., and L.M.; supervision: G.M. and A.C.
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Marletta, S., Martignoni, G., Ghimenton, C. et al. Well-differentiated neuroendocrine tumor of the urinary bladder expressing GATA 3. Virchows Arch 482, 783–788 (2023). https://doi.org/10.1007/s00428-022-03478-2
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DOI: https://doi.org/10.1007/s00428-022-03478-2