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Spleen volume is a predictor of posthepatectomy liver failure and short-term mortality for hepatocellular carcinoma

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Abstract

Background

The study aimed at retrospectively assessing the impact of spleen volume (SpV) on the development of posthepatectomy liver failure (PHLF) in patients who underwent hepatectomy for hepatocellular carcinoma (HCC).

Methods

152 patients with primary HCC who underwent hepatectomy (sectionectomy or more) were classified into PHLF and non-PHLF groups, and then the relationship between PHLF and SpV was assessed. SpV (cm3) was obtained from preoperative CT and standardized based on the patient’s body surface area (BSA, m2).

Results

PHLF was observed in 39 (26%) of the 152 cases. SpV/BSA was significantly higher in the PHLF group, and the postoperative 1-year survival rate was significantly worse in the PHLF group than that in the non-PHLF group (p = 0.044). Multivariable analysis revealed SpV/BSA as a significant independent risk factor for PHLF. Using the cut-off value (160 cm3/m2), the 152 cases were divided into small SpV and large SpV groups. The incidence of PHLF was significantly higher in the large SpV group (p = 0.002), the liver failure-related mortality rate was also significantly higher in the large SpV group (p = 0.007), and the 1-year survival rate was significantly worse in the large SpV group (p = 0.035).

Conclusion

These results suggest SpV as a predictor of PHLF and short-term mortality in patients who underwent hepatectomy for HCC. Moreover, SpV measurement is a simple and potentially useful method for predicting PHLF in patients with HCC.

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Data Availability

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

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Author information

Authors and Affiliations

  1. Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan

    Takahiro Ito, Akihiro Tanemura, Toru Kuramitsu, Taichi Murase, Benson Kaluba, Daisuke Noguchi, Tekehiro Fujii, Takuya Yuge, Koki Maeda, Aoi Hayasaki, Kazuyuki Gyoten, Yusuke Iizawa, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada & Shugo Mizuno

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  1. Takahiro Ito
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  2. Akihiro Tanemura
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  3. Toru Kuramitsu
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  4. Taichi Murase
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  5. Benson Kaluba
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  16. Shugo Mizuno
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Contributions

Ito, Tanemura, Kuramitsu, and Murase participated in the study conception and design. Ito, Tanemura, Kuramitsu, Murase, Noguchi, Fujii, and Kuriyama participated in the acquisition of data. Ito, Kuramitsu, Murase, Tenemura, and Noguchi participated in the analysis and interpretation of data. Ito, Tanemura, and Kuramitsu drafted the manuscript. Kaluba, Fujii, Noguchi, Yuge, Maeda, Hayasaki, Gyoten, Iizawa, Murata, Kuriyama, Kishiwada, and Mizuno participated in the critical revision of the manuscript.

Corresponding author

Correspondence to Takahiro Ito.

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Ethics approval and consent to participate

This study was approved by Mie University Hospital Institutional Review Board (IRB#H2021-156).

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The authors declare no competing interests.

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Ito, T., Tanemura, A., Kuramitsu, T. et al. Spleen volume is a predictor of posthepatectomy liver failure and short-term mortality for hepatocellular carcinoma. Langenbecks Arch Surg 408, 297 (2023). https://doi.org/10.1007/s00423-023-03025-w

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