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Long-term survival in patients with distal cholangiocarcinoma after pancreaticoduodenectomy combined with portal vein system resection and reconstruction

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Abstract

Purpose

Pancreaticoduodenectomy combined with portal vein resection for distal cholangiocarcinoma is rarely reported because it is a rare disease. We developed a program to evaluate the vascular invasion type, operation procedure, and long-term survival of distal cholangiocarcinoma patients with portal vein invasion.

Methods

We retrospectively reviewed data for 123 distal cholangiocarcinoma patients after pancreaticoduodenectomy between January 2013 and December 2019. Portal vein system invasion was confirmed pathologically in 17 patients.

Results

Multivariable Cox regression identified tumor differentiation degree, portal vein system invasion, and lymph node metastasis as independent risk factors affecting long-term survival. The 1- and 2-year overall survival rates for patients without and with portal vein system invasion were 79.7% and 58.9%, and 48.6% and 10.8%, respectively. Median overall survival in patients without and with portal vein system invasion was 33 months and 12 months, respectively.

Conclusion

Portal vein system invasion is an important independent risk factor affecting long-term survival in patients with distal cholangiocarcinoma. Pancreaticoduodenectomy combined with portal vein system resection and reconstruction did not increase the incidence of perioperative complications or mortality.

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Acknowledgements

We thank the patients for their participation in this study. This paper is supported by Dr HQ.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongtinan Road, Chaoyang District, Beijing, 100020, China

    Shaocheng Lyu, Fangfei Wang, Zhangyong Ren, Di Cao & Qiang He

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  1. Shaocheng Lyu
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  2. Fangfei Wang
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  3. Zhangyong Ren
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  4. Di Cao
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  5. Qiang He
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Contributions

HQ proposed the study. LSC performed the research and wrote the first draft of the manuscript. All authors contributed to the design and interpretation of the study and to further drafts. HQ is the guarantor.

Corresponding author

Correspondence to Qiang He.

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Ethics approval and consent to participate

Our research was approved by the Ethics Committee of Beijing Chaoyang Hospital (approval number: 2020-D-141).

Competing interests

The authors declare no competing interests.

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Lyu, S., Wang, F., Ren, Z. et al. Long-term survival in patients with distal cholangiocarcinoma after pancreaticoduodenectomy combined with portal vein system resection and reconstruction. Langenbecks Arch Surg 406, 1917–1924 (2021). https://doi.org/10.1007/s00423-021-02177-x

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  • DOI: https://doi.org/10.1007/s00423-021-02177-x

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