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The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis

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International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Abstract

Objective

The convoluted element of PM2.5 may cause various biological reactions. Nowadays, few studies have indicated the long-term health effects of PM2.5 on HCC. Therefore, this meta-analysis first aims to obtain more precise estimates of the effects of PM2.5 exposure on HCC to assess the strength of the evidence.

Methods

A combination of computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. Review Manager 5.3 software was used to examine the heterogeneity among the studies.

Results

Finally, 8 qualified articles meet the inclusion criteria. The results were I2 = 0%, P > 0.1 indicating that there was no heterogeneity. The results showed that the concentration of PM2.5 increased by 10 μg/m3 was significantly correlated with liver cancer, and HR was 1.22 (95% CI 1.14–1.30, P < 0.05), indicating that maternal exposure to PM2.5 was positively correlated with liver cancer.

Conclusions

Our meta-analysis showed that the patients with HCC significance related to PM2.5 exposure. However, more studies investigating the combined effects of different air pollutants on HCC incidence are warranted to provide more comprehensive evidence for assessing the different levels impacts of PM2.5 exposure on HCC incidence.

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Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Acknowledgements

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Funding

This work is supported by National Nature Science Foundation of China, Grant/Award Numbers: 81600800.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

    Zeng-Hong Wu & Hong Yu

  2. Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Zeng-Hong Wu

  3. School of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang, China

    Meng Zhao

  4. Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China

    Meng Zhao

  5. Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Hua-Dong Li

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  1. Zeng-Hong Wu
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  2. Meng Zhao
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  3. Hong Yu
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  4. Hua-Dong Li
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Contributions

WZH and ZM designed and analyzed the research study; WZH and YH wrote and revised the manuscript, WZH and LHD collected the data and have read and approved the manuscript.

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Correspondence to Hong Yu or Hua-Dong Li.

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Wu, ZH., Zhao, M., Yu, H. et al. The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis. Int Arch Occup Environ Health 95, 677–683 (2022). https://doi.org/10.1007/s00420-021-01773-0

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  • DOI: https://doi.org/10.1007/s00420-021-01773-0

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