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Use of axial length to estimate the vitreous chamber volume in pseudophakic

  • Retinal Disorders
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Abstract

Purpose

To develop an equation for estimating the vitreous chamber volume in pseudophakic patients based on the axial length of the eye.

Methods

A consecutive series of patients who underwent vitrectomy surgery for a macular hole or an epiretinal membrane were enrolled. The inclusion criteria were as follows: having pseudophakia, being older than 50 years, and having eyes with axial length ranging from 21 to 26 mm. Before the surgery, the axial length was measured using optical biometry. Pars plan vitrectomy was performed, and, after the fluid-air exchange, the vitreous chamber was filled with Brilliant Blue G (0.005%). The infused volume of each eye was recorded. Then, epiretinal membrane peeling or internal limiting membrane peeling and a new fluid-air exchange were performed. Main outcomes and measures were the vitreous chamber volume and axial length.

Results

The sample consisted of 112 patients. The mean [standard deviation (SD), range] age was 71 years (7, 53–90). Sixty-five individuals (58%) were women. In 58 (51.8%) patients, surgery was performed on the right eye. The mean (SD; range) axial length was 23.78 mm (0.93; 21.55–25.26), and the mean (SD; range) vitreous chamber volume was 4.96 mL (0.69; 3.60—6.40). Pearson’s correlation coefficient (r = 0.950; p < 0.01) was positive, and the coefficient of determination (R2) was 0.902. The estimated regression equation was Y = 0.71X − 11.84, where Y was the vitreous chamber volume, X was the axial length of the eye, the linear coefficient for the straight line was − 11.83, and the angular coefficient was 0.71 (p < 0.01).

Conclusion

These data suggest that the vitreous chamber volume is significantly correlated with the axial length and the former could probably be calculated using biometry. New studies with larger samples will be required to confirm these observations and will allow the development of an algorithm (perhaps non-linear) that includes extreme axial length values and that takes into account other factors such as the status of the lens and sex.

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Data availability

We had full access to the data and take responsibility for the scientific accuracy of the research findings, data integrity, and research methods used.

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Author notes

  1. Juliana Moreira de Santana

    Present address: , Salvador, Brazil

Authors and Affiliations

  1. Universidade Federal de Pernambuco, Recife, Brazil

    Juliana Moreira de Santana, Gabriel Guerra Cordeiro, Daniel Tenório Camelo Soares, Marília Rocha Costa, Alexandre Paashaus da Costa Pinto & Rodrigo Pessoa Cavalcanti Lira

  2. Universidade Estadual de Campinas, Campinas, Brazil

    Rodrigo Pessoa Cavalcanti Lira

Authors
  1. Juliana Moreira de Santana
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  2. Gabriel Guerra Cordeiro
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  3. Daniel Tenório Camelo Soares
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  4. Marília Rocha Costa
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  5. Alexandre Paashaus da Costa Pinto
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  6. Rodrigo Pessoa Cavalcanti Lira
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Corresponding author

Correspondence to Juliana Moreira de Santana.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

This study was approved by the Research Ethics Committee (CAAE no. 26684819.4.0000.8807) of Hospital das Clínicas at Universidade Federal de Pernambuco (HC-UFPE).

Consent to participate

All the patients signed an informed consent form regarding the risks and benefits of the surgical procedure to which they were submitted.

Consent for publication

In consideration that Graefe’s Archive for Clinical and Experimental Ophthalmology is taking action in reviewing and editing our submission, which represents an original article, the authors hereby transfer, assign, or otherwise convey all copyright ownership to the Springer, in the event that this work is published in the journal Graefe’s Archive. The manuscript is not being considered for publication elsewhere, and there are no other manuscripts being submitted from this same study.

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Institution where the work was done: Universidade Federal de Pernambuco, Recife, Brazil

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de Santana, J.M., Cordeiro, G.G., Soares, D.T.C. et al. Use of axial length to estimate the vitreous chamber volume in pseudophakic. Graefes Arch Clin Exp Ophthalmol 259, 1471–1475 (2021). https://doi.org/10.1007/s00417-020-04991-3

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  • DOI: https://doi.org/10.1007/s00417-020-04991-3

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