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Retina thickness in atypical parkinsonism: a systematic review and meta-analysis

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Abstract

Background and purpose

To investigate the retina thickness assessed using optical coherence tomography in atypical parkinsonism in comparison with health controls (HC) and patients with Parkinson’s disease (PD).

Methods

PubMed and EMBASE were searched for potentially eligible studies that reported retina thickness in atypical parkinsonism

[including progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and corticobasal degeneration] in comparison with that of HC and PD patients from their dates of inception to Jan 24, 2021. Mean difference (μm) of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and central macular thickness (CMT) were pooled with random effects model.

Results

We included ten studies eligible for inclusion criteria. Average pRNFL thickness and average CMT were thinner in PSP [pooled mean difference (μm) of − 4.71, 95% CI (− 7.15, − 2.27); − 15.12, 95% CI (− 16.93, − 13.30)] and in MSA [− 5.37, 95% CI (− 6.59, − 4.15); − 5.93, 95% CI (− 11.00, − 0.87)] compared with HC, and were thinner in PSP [− 5.81, 95% CI (− 8.92, − 2.69); − 10.63, 95% CI (− 20.29, − 0.98)] and in MSA [− 0.35 μm, 95% CI (− 5.72, 5.01); − 7.42 μm [95% CI (− 12.46, − 2.38)] compared with PD. The pRNFL thickness was thinning in superior, inferior and nasal quadrants, and CMT was thinning in outer sectors in MSA compared with HC.

Conclusions

The retina thickness was significantly thinner in PSP and MSA than those in HC and PD. The specific patterns of retina thinning in MSA could be clinical importance for differentiation among atypical parkinsonism.

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Data availability

The data relative to the study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Ophthalmology, The First Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang, 110001, People’s Republic of China

    Xiaoli Ma, Nan Wang & Ruijun Zhang

  2. Department of Neurology, People’s Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People’s Republic of China

    Yujie Wang

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  1. Xiaoli Ma
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  2. Yujie Wang
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Contributions

RJZ and YJW contributed to the study conception and design. RJZ and YJW did the systematic literature search, selected studies for inclusion, extracted data, and statistical analyses, made figures. XLM, NW, RJZ and YJW interpreted data. YJW, RJZ, XLM wrote the first draft of the manuscript. All authors revised the manuscript for important intellectual content, approved the final draft.

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Correspondence to Ruijun Zhang.

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The authors report no conflicts of interest or no disclosures relevant to the manuscript.

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Ma, X., Wang, Y., Wang, N. et al. Retina thickness in atypical parkinsonism: a systematic review and meta-analysis. J Neurol 269, 1272–1281 (2022). https://doi.org/10.1007/s00415-021-10703-6

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  • DOI: https://doi.org/10.1007/s00415-021-10703-6

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