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Diagnostic Performance of the Herder Model in Veterans Undergoing PET Scans for Pulmonary Nodule Evaluation

  • PET SCAN PULMONARY NODULE EVALUATION
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Abstract

British Thoracic Society (BTS) guidelines recommend using the Herder model to risk-stratify lung nodules after positron emission tomography (PET). However, this approach has not been adequately evaluated, particularly among Veterans. A single-center retrospective cohort study was carried out in U.S. Veterans with pulmonary nodules assessed by PET to validate the Herder model; decision analysis using risk thresholds from the BTS guidelines was performed. One hundred subjects met inclusion criteria. Area under the curve of the Herder model for predicting malignancy was 0.87 for all lung nodules and 0.90 for newly discovered nodules. For low- and high-risk lung nodules, BTS guidelines would have recommended appropriate care in this patient cohort.

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Acknowledgements

YV had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors contributed substantially to the study design, data analysis and interpretation, and the writing of the manuscript. The views expressed are those of the authors and do not reflect the official policy or position of the US Government or the U.S Department of Veterans Affairs. The authors of this study have no conflicts of interest to declare.

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This research was not funded.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Providence VA Medical Center, 830 Chalkstone Avenue, Office 158L, Providence, RI, 02908, USA

    Yevgeniy Vayntrub, Eric Gartman, Linda Nici & Matthew D. Jankowich

  2. Warren Alpert Medical School of Brown University, Providence, RI, USA

    Yevgeniy Vayntrub, Eric Gartman, Linda Nici & Matthew D. Jankowich

Authors
  1. Yevgeniy Vayntrub
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  2. Eric Gartman
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  3. Linda Nici
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  4. Matthew D. Jankowich
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Correspondence to Matthew D. Jankowich.

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Conflict of interest

The views expressed are those of the authors and do not reflect the official policy or position of the US Government or the U.S Department of Veterans Affairs. The authors of this study have no conflicts of interest to declare.

Ethical Approval

This study was reviewed by the Providence VA Medical Center Institutional Review Board and was found to be exempt from Institutional Review Board review.

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Not applicable. A waiver of consent was approved by the Institutional Review Board.

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Vayntrub, Y., Gartman, E., Nici, L. et al. Diagnostic Performance of the Herder Model in Veterans Undergoing PET Scans for Pulmonary Nodule Evaluation. Lung 199, 653–657 (2021). https://doi.org/10.1007/s00408-021-00495-x

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  • DOI: https://doi.org/10.1007/s00408-021-00495-x

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