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Analysis of the association between vestibular schwannoma and hearing status using a newly developed radiomics technique

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Vestibular schwannoma is a benign tumor originating from Schwann cells surrounding the eighth cranial nerve and can cause hearing loss, tinnitus, balance problems, and facial nerve disorders. Because of the slow growth of the tumor, predicting the hearing function of patients with vestibular schwannoma’s is important to obtain information that would be useful for deciding the treatment modality. This study aimed to analyze the association between magnetic resonance imaging features and hearing status using a new radiomics technique.

Methods

We retrospectively analyzed 115 magnetic resonance images and hearing results from 73 patients with vestibular schwannoma. A total of 70 radiomics features from each tumor volume were calculated using T1-weighted magnetic resonance imaging. Radiomics features were classified as histogram-based, shape-based, texture-based, and filter-based. The least absolute shrinkage and selection operator method was used to select the radiomics features among the 70 features that best predicted the hearing test. To ensure the stability of the selected features, the least absolute shrinkage and selection operator method was repeated 10 times. Finally, features set five or more times were selected as radiomics signatures.

Results

The radiomics signatures selected using the least absolute shrinkage and selection operator method were: minimum, variance, maximum 3D diameter, size zone variance, log skewness, skewness slope, and kurtosis slope. In random forest, the mean performance was 0.66 (0.63–0.77), and the most important feature was Log skewness.

Conclusions

Newly developed radiomics features are associated with hearing status in patients with vestibular schwannoma and could provide information when deciding the treatment modality.

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Availability of data and materials

The data sets generated and/or analyzed during the current study are not publicly available due to the legal restrictions of South Korea. However, they are available from the corresponding author upon reasonable request.

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Funding

This study was supported by (1) a Korea University Grant, (2) a Grant of the Medical data-driven hospital support project through the Korea Health Information Service (KHIS), funded by the Ministry of Health and Welfare, Republic of Korea, and (3) the MSIT (Ministry of Science and ICT), Korea, under the ICAN (ICT Challenge and Advanced Network of HRD) program (IITP-2023-RS-2022-00156439) supervised by the IITP (Institute of Information and Communications Technology Planning and Evaluation).

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Author notes

  1. Kang Hyeon Lim and Seung-hak Lee have contributed equally to this work as first authors.

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital, Korea University, 123, Jeokgeum-ro, Danwon-gu, Ansan-Si, Gyeonggi-do, 15355, Republic of Korea

    Kang Hyeon Lim, Insik Song, Hee Soo Yoon, Hong Jin Kim, Ye Hwan Lee, Eunjin Kim, Yoon Chan Rah & June Choi

  2. Core Research & Development Center, Korea University, Ansan Hospital, Ansan, Republic of Korea

    Seung-hak Lee

  3. Department of Medical Informatics, Korea University College of Medicine, Seoul, Republic of Korea

    June Choi

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  1. Kang Hyeon Lim
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Corresponding author

Correspondence to June Choi.

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Conflict of interest

All authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval

This study was approved by the Institutional Review Board of Korea University Ansan Hospital (No: 2022AS0300). The requirement for informed consent was waived due to the retrospective nature of the study.

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Lim, K.H., Lee, Sh., Song, I. et al. Analysis of the association between vestibular schwannoma and hearing status using a newly developed radiomics technique. Eur Arch Otorhinolaryngol 281, 2951–2957 (2024). https://doi.org/10.1007/s00405-023-08410-1

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