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Aberrant dynamic functional network connectivity in vestibular migraine patients without peripheral vestibular lesion

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Abstract

Purpose

This study aimed to investigate changes in dynamic functional network connectivity (FNC) in patients with vestibular migraine (VM) and explore their relationship with clinical manifestations.

Methods

Resting-state functional magnetic resonance imaging (rs-fMRI) data were scanned from 35 VM patients without peripheral vestibular lesion and 40 age-, sex- and education-matched healthy controls (HC). Independent component analysis (ICA), sliding window (SW) and k-means clustering analysis were performed to explore the difference in FNC and temporal characteristics between two groups. Additionally, Pearson’s partial correlation analysis was adopted to investigate the relationship between clinical manifestations and rs-fMRI results in patients with VM.

Results

Compared with HC, patients with VM showed increased FNC in pairs of extrastriate visual network (eVN)-ventral attention network (VAN), eVN-default mode network (DMN) and eVN-left frontoparietal network (lFPN), and exhibited decreased FNC in pairs of VAN-auditory network (AuN). The altered FNC was correlated with clinical manifestations of patients with VM. Additionally, we found increased mean dwell time and fractional windows in state 2 in VM patients compared with HC. Mean dwell time was positively correlated with headache impact test-6 (HIT-6) scores, fractional windows was positively associated with dizziness handicap inventory (DHI) scores.

Conclusion

Our results indicated that patients with VM showed altered FNC primarily between sensory networks and networks related to cognitive, emotional and attention implementation, with more time spent in a state characterized by positive FNC between sensor cortex system and dorsal attention network (DAN). These findings could help reinforce the understanding on the neural mechanisms of VM.

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Funding

The study was supported by grants from the Xuzhou Municipal Health Commission (No. XWKYHT20200010) and Xuzhou Science and Technology Bureau (No. KC20077; No. KC18161).

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Authors and Affiliations

  1. Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, No. 32, Meijian Road, Xuzhou, 221006, Jiangsu Province, China

    Zhengwei Chen, Haiyan Liu, Xiu-e Wei, Yueji Liu, Lei Hao, Cunxin Lin, Lijie Xiao & Liangqun Rong

  2. Medical Imaging Department, Second Affiliated Hospital of Xuzhou Medical University, No. 32, Meijian Road, Xuzhou, 221006, Jiangsu Province, China

    Quan Wang

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  1. Zhengwei Chen
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Chen, Z., Liu, H., Wei, Xe. et al. Aberrant dynamic functional network connectivity in vestibular migraine patients without peripheral vestibular lesion. Eur Arch Otorhinolaryngol 280, 2993–3003 (2023). https://doi.org/10.1007/s00405-023-07847-8

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