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Primary prevention of depression in head and neck cancer patients: a scoping review

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Abstract

Objectives

To conduct a scoping review of the literature on psychological interventions directed to identify primary prevention strategies for depression among adult head and neck cancer (HNC) patients.

Methods

Systematic searches were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Review including relevant studies within the PubMed, PsycINFO, and EMBASE databases. Two authors independently screened the searches and reviewed the included articles according to the predetermined eligibility criteria based on the PICOS format. Studies included subjects with previous or current diagnosis of depression were excluded. The risk of bias assessment of these trials was conducted following the Cochrane tool for assessing the risk of bias in randomized trials. The search was repeated prior to submission to ensure all current articles meeting criteria were included.

Results

The search yielded 875 studies. The title and abstract screen, followed by the review of full texts identified five articles that met inclusion criteria. Four were randomized controlled trials (RCT) and the fifth was a non-randomized but controlled study. Different psychosocial interventions were used, including psycho-educational interventions, psychosocial counseling, and pharmacotherapy. All studies established the diagnosis of depression or screened for the diagnosis using standardized psychiatric assessment tools, either Diagnostic and Statistical Manual of Mental Disorders criteria or validated patient reported outcome measures. The average follow-up periods after intervention was 9.8 months. There was a significant decrease in the incidence of depression or depressive symptoms favoring the intervention group in three out of the five studies that were included.

Conclusion

Psychological interventions identified thus far studying primary prevention of depression in HNC patients show promising results. However, the paucity of data and heterogeneity of the interventions challenges the ability to compare the prevention modalities and outcomes. Future well-designed RCTs with large sample sizes are recommended to better conclude a result of effectiveness.

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References

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249

    Article  PubMed  Google Scholar 

  2. Howren MB, Christensen AJ, Karnell LH, Funk GF (2013) Psychological factors associated with head and neck cancer treatment and survivorship: evidence and opportunities for behavioral medicine. J Consult Clin Psychol 81(2):299–317

    Article  PubMed  Google Scholar 

  3. Sehlen S, Lenk M, Herschbach P, Aydemir U, Dellian M, Schymura B, Hollenhorst H, Dühmke E (2003) Depressive symptoms during and after radiotherapy for head and neck cancer. Head Neck 25(12):1004–1018

    Article  PubMed  Google Scholar 

  4. Lue BH, Huang TS, Chen HJ (2008) Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy. Int J Radiat Oncol Biol Phys 70(1):28–34

    Article  PubMed  Google Scholar 

  5. Wagner KD, Robb AS, Findling RL, Jin J, Gutierrez MM, Heydorn WE (2004) A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents. Am J Psychiatry 161(6):1079–1083

    Article  PubMed  Google Scholar 

  6. Barber B, Dergousoff J, Slater L, Harris J, O’Connell D, El-Hakim H, Biron VL, Mitchell N, Seikaly H (2016) Depression and survival in patients with head and neck cancer: a systematic review. JAMA Otolaryngol Head Neck Surg 142(3):284–288

    Article  PubMed  Google Scholar 

  7. Ehlers SL (2002) Effects of depression and substance use on head and neck cancer mortality. The University of Iowa, Iowa

    Google Scholar 

  8. Lazure KE, Lydiatt WM, Denman D, Burke WJ (2009) Association between depression and survival or disease recurrence in patients with head and neck cancer enrolled in a depression prevention trial. Head Neck 31(7):888–892

    Article  PubMed  Google Scholar 

  9. Rieke K, Schmid KK, Lydiatt W, Houfek J, Boilesen E, Watanabe-Galloway S (2017) Depression and survival in head and neck cancer patients. Oral Oncol 65:76–82

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kam D, Salib A, Gorgy G, Patel TD, Carniol ET, Eloy JA, Baredes S, Park RC (2015) Incidence of suicide in patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg 141(12):1075–1081

    Article  PubMed  Google Scholar 

  11. Osazuwa-Peters N, Simpson MC, Zhao L, Boakye EA, Olomukoro SI, Deshields T, Loux TM, Varvares MA, Schootman M (2018) Suicide risk among cancer survivors: head and neck versus other cancers. Cancer 124(20):4072–4079

    Article  PubMed  Google Scholar 

  12. Semple C, Parahoo K, Norman A, McCaughan E, Humphris G, Mills M (2013) Psychosocial interventions for patients with head and neck cancer. Cochrane Database Syst Rev 7:CD009441

    Google Scholar 

  13. Fawzy FIFN, Arndt LA, Pasnau RO (1995) Critical review of psychosocial interventions in cancer care. Arch Gen Psychiatry 52(2):100–113

    Article  CAS  PubMed  Google Scholar 

  14. Duffy SA, Ronis DL, Valenstein M, Lambert MT, Fowler KE, Gregory L, Bishop C, Myers LL, Blow FC, Terrell JE (2006) A tailored smoking, alcohol, and depression intervention for head and neck cancer patients. Cancer Epidemiol Biomark Prev 15(11):2203–2208

    Article  Google Scholar 

  15. Kisling LA, MD J (2022) Prevention strategies. In: StatPearls. StatPearls Publishing LLC, Treasure Island

  16. Lydiatt WM, Denman D, McNeilly DP, Puumula SE, Burke WJ (2008) A randomized, placebo-controlled trial of citalopram for the prevention of major depression during treatment for head and neck cancer. Arch Otolaryngol Head Neck Surg 134(5):528–535

    Article  PubMed  Google Scholar 

  17. McLaughlin KA (2011) The public health impact of major depression: a call for interdisciplinary prevention efforts. Prev Sci 12(4):361–371

    Article  PubMed  PubMed Central  Google Scholar 

  18. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898

    Article  PubMed  Google Scholar 

  19. Methods guide for effectiveness and comparative effectiveness reviews. https://effectivehealthcare.ahrq.gov/products/collections/cer-methods-guide

  20. Lydiatt WM, Bessette D, Schmid KK, Sayles H, Burke WJ (2013) Prevention of depression with escitalopram in patients undergoing treatment for head and neck cancer: randomized, double-blind, placebo-controlled clinical trial. JAMA Otolaryngol Head Neck Surg 139(7):678–686

    PubMed  Google Scholar 

  21. Katz MR, Irish JC, Devins GM (2004) Development and pilot testing of a psychoeducational intervention for oral cancer patients. Psychooncology 13(9):642–653

    Article  PubMed  Google Scholar 

  22. D’Souza V, Blouin E, Zeitouni A, Muller K, Allison PJ (2013) An investigation of the effect of tailored information on symptoms of anxiety and depression in head and neck cancer patients. Oral Oncol 49(5):431–437

    Article  CAS  PubMed  Google Scholar 

  23. Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67(6):361–370

    Article  CAS  PubMed  Google Scholar 

  24. Snaith RP, Zigmond AS (1986) The hospital anxiety and depression scale. Br Med J (Clin Res Ed) 292(6516):344

    Article  CAS  PubMed  Google Scholar 

  25. van der Meulen IC, May AM, de Leeuw JR, Koole R, Oosterom M, Hordijk GJ, Ros WJ (2014) Long-term effect of a nurse-led psychosocial intervention on health-related quality of life in patients with head and neck cancer: a randomised controlled trial. Br J Cancer 110(3):593–601

    Article  PubMed  Google Scholar 

  26. Yadav P, Karkal R, Kakunje A, Mahatme N, Akhilesh M (2019) Prevalence of depressive disorders among head-and-neck cancer patients: a hospital-based, cross-sectional study. Indian J Psychiatry 61(4):409–414

    Article  PubMed  PubMed Central  Google Scholar 

  27. Robinson RG, Jorge RE, Long J (2017) Prevention of poststroke mortality using problem-solving therapy or escitalopram. Am J Geriatr Psychiatry 25(5):512–519

    Article  PubMed  Google Scholar 

  28. Lewinsohn PM, Seeley JR, Roberts RE, Allen NB (1997) Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults. Psychol Aging 12(2):277–287

    Article  CAS  PubMed  Google Scholar 

  29. Radloff LS (1977) The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1(3):385–401

    Article  Google Scholar 

  30. Amster WW, Love RJ, Menzel OJ, Sandler J, Sculthorpe WB, Gross FM (1972) Psychosocial factors and speech after laryngectomy. J Commun Disord 5(1):1–18

    Article  Google Scholar 

  31. Blanchard SL (1982) Current practices in the counseling of the laryngectomy patient. J Commun Disord 15(3):233–241

    Article  CAS  PubMed  Google Scholar 

  32. Carroll-Alfano MA (2019) Education, counseling, support groups, and provider knowledge of total laryngectomy: the patient’s perspective. J Commun Disord 82:105938

    Article  PubMed  Google Scholar 

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, King Abdulaziz University, Jeddah, Saudi Arabia

    Rawan Arif, Hani Z. Marzouki, Rahaf Al Thomali & Mazin Merdad

  2. Department of Otolaryngology-Head and Neck Surgery, McGill University Health Centre, 1001 Decarie Boulevard, Montreal, QC, Canada

    Rawan Arif, Jennifer A. Silver & Nader Sadeghi

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  1. Rawan Arif
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  2. Hani Z. Marzouki
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  3. Jennifer A. Silver
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  4. Rahaf Al Thomali
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Correspondence to Rawan Arif.

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Arif, R., Marzouki, H.Z., Silver, J.A. et al. Primary prevention of depression in head and neck cancer patients: a scoping review. Eur Arch Otorhinolaryngol 280, 1547–1554 (2023). https://doi.org/10.1007/s00405-022-07783-z

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  • DOI: https://doi.org/10.1007/s00405-022-07783-z

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