Skip to main content

Advertisement

SpringerLink
Log in

Bone turnover in chronic otitis media with bone destruction

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

This study aims to determine the relationship between bone destruction and bone turnover markers in patients with chronic otitis media (COM).

Methods

Subjects with COM were divided into two groups: those with and without bone destruction. Thirty-seven patients were included in the group with bone destruction; 30 patients were included in the group without bone destruction. The enzyme values were evaluated.

Results

There was no difference between the two groups in terms of enzyme levels of serum and urine. However, the osteocalcin, which is a bone formation marker, and the C-terminal telopeptide of type I collagen marker, which is bone destruction marker, were found to be lower in the group with bone destruction than the group without bone destruction.

Conclusion

Data obtained in the present study suggest that the pressure necrosis theory and acid lysis theory provide the most valid explanations of bone destruction. However, the data provide limited preliminary information to clarify this mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Master A, Wilkinson E, Wagner R (2018) Management of chronic suppurative otitis media and otosclerosis in developing countries. Otolaryngol Clin North Am 51(3):593–605. https://doi.org/10.1016/j.otc.2018.01.017

    Article  PubMed  Google Scholar 

  2. Gerami H, Naghavi E, Wahabi-Moghadam M, Forghanparast K, Akbar MH (2009) Comparison of preoperative computerized tomography scan imaging of temporal bone with the intra-operative findings in patients undergoing mastoidectomy. Saudi Med J 30(1):104–108

    PubMed  Google Scholar 

  3. Peek F, Huisman M, Berckmans R, Sturk A, van Loon J, Grote J (2003) Lipopolysaccharide concentration and bone resorption in cholesteatoma. Otol Neurotol 24(5):709–713

    Article  CAS  Google Scholar 

  4. Xie S, Wang X, Ren J, Liu W (2017) The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma. Eur Arch Otorhinolaryngol 274(5):2071–2078. https://doi.org/10.1007/s00405-016-4422-6

    Article  PubMed  Google Scholar 

  5. Hlaing TT, Compston JE (2014) Biochemical markers of bone turnover - uses and limitations. Ann Clin Biochem 51(Pt 2):189–202. https://doi.org/10.1177/0004563213515190

    Article  PubMed  Google Scholar 

  6. Konukoglu D (2019) Bone markers. Int J Med Biochem 2(2):65–78

    Google Scholar 

  7. Nguyen KH, Suzuki H, Ohbuchi T, Wakasugi T, Koizumi H, Hashida K, Baba R, Morimoto H, Doi Y (2014) Possible participation of acidic pH in bone resorption in middle ear cholesteatoma. Laryngoscope 124(1):245–250

    Article  CAS  Google Scholar 

  8. Si Y, Chen YB, Chen SJ, Zheng YQ, Liu X, Liu Y, Jiang HL, Xu G, Li ZH, Huang QH (2015) TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction. Sci Rep 5:16683

    Article  CAS  Google Scholar 

  9. Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Itoi-Ochi S, Penninger JM, Katayama I, Inohara H, Ishii M (2016) Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Mol Cell Biol 36(11):1610–1620. https://doi.org/10.1128/mcb.01028-15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Jeong JH, Park CW, Tae K, Lee SH, Shin DH, Kim KR, Park YW (2006) Expression of RANKL and OPG in middle ear cholesteatoma tissue. Laryngoscope 116(7):1180–1184. https://doi.org/10.1097/01.mlg.0000224345.59291.da

    Article  CAS  PubMed  Google Scholar 

  11. Chen AP, Wang B, Zhong F, Song GZ, Song HF, Yu K, Wang HB, Jiang ZH (2015) Expression levels of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin are associated with middle ear cholesteatoma risk. Acta Otolaryngol 135(7):655–666. https://doi.org/10.3109/00016489.2015.1011789

    Article  CAS  PubMed  Google Scholar 

  12. Abramson M, Moriyama H, Huang CC (1984) Pathogenic factors in bone resorption in cholesteatoma. Acta Otolaryngol 97(5–6):437–442. https://doi.org/10.3109/00016488409132918

    Article  CAS  PubMed  Google Scholar 

  13. Macri JR, Chole RA (1985) Bone erosion in experimental cholesteatoma–the effects of implanted barriers. Otolaryngol Head Neck Surg 93(1):3–17. https://doi.org/10.1177/019459988509300102

    Article  CAS  PubMed  Google Scholar 

  14. Yetişer S, Hıdır Y, Deveci MS (2005) Morphologic changes of middle ear mucosa in chronic otitis media with or without cholesteatoma. The Mediterr J Otol 4:102–108

    Google Scholar 

Download references

Funding

This study was support of the Scientific Research Projects Coordinatorship of the University of Health Sciences (Project No: 2018/021).

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, University of Health Sciences Turkey-Samsun Health Practices and Research Center, Kadıköy Mah. Park Sok. No: 199, PB: 55090, İlkadım, Samsun, Turkey

    Tuğba Yemiş, Abdulkadir Özgür, Doğukan Özdemir, Gökhan Akgül, Dursun Mehmet Mehel & Mehmet Çelebi

  2. Microbiology Laboratory, University of Health Sciences Turkey Samsun Education and Research Hospital, Samsun, Turkey

    Eşe Başbulut & Melek Bilgin Acar

Authors
  1. Tuğba Yemiş
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abdulkadir Özgür
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eşe Başbulut
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Doğukan Özdemir
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gökhan Akgül
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dursun Mehmet Mehel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Melek Bilgin Acar
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mehmet Çelebi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abdulkadir Özgür.

Ethics declarations

Conflict of interest

The authors declare that they have no confict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (University of Health Sciences Samsun Education and Research Hospital Clinical Research Ethics Committee dated 08.02.2018 and numbered 2018/23) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yemiş, T., Özgür, A., Başbulut, E. et al. Bone turnover in chronic otitis media with bone destruction. Eur Arch Otorhinolaryngol 277, 2229–2233 (2020). https://doi.org/10.1007/s00405-020-05970-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-020-05970-4

Keywords

Search

Navigation