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Risk of breast cancer among patients with psoriasis: a systematic review and meta-analysis

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Abstract

Relevant evidence regarding the risk of incident breast cancer in patients with psoriasis is lacking. Hence, this systematic review and meta-analysis aimed to assess the risk of breast cancer in patients with psoriasis. We searched the PubMed, Cochrane Library, and Embase databases from inception to December 31, 2021, for relevant cohort studies without language limitations. The Newcastle–Ottawa Scale was used to determine the quality of the selected papers. A random-effects model meta-analysis was performed to obtain the pooled hazard ratio (HR) with a 95% confidence interval (CI) for breast cancer in relation to psoriasis. We also performed a subgroup analysis of patients with mild-to-moderate-to-severe psoriasis. We included seven cohort studies, all of which were considered high quality, and three of them provided data for meta-analysis. The risk for breast cancer did not increase among patients with psoriasis (pooled HR: 1.11, 95% CI 0.97–1.27; I2 = 67%). In the subgroup analysis, the risk for breast cancer did not significantly increase among patients with mild psoriasis (pooled HR: 1.04, 95% CI 0.97–1.12; I2 = 6%), and the risk for breast cancer did not significantly increase among those with moderate-to-severe psoriasis (pooled HR: 0.96, 95% CI 0.72–1.28; I2 = 0%). Patients with mild or moderate-to-severe psoriasis are not at an elevated risk of breast cancer.

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Acknowledgements

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Funding

This study was partly supported by the grants from the Science and Technology Plan Project in Taizhou (22ywb15).

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Authors and Affiliations

  1. Evidence-based Medicine Center, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China

    Tao-Hsin Tung

  2. School of Public Health, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, China

    Zhu Liduzi Jiesisibieke

  3. Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan

    Yu-Hsien Cheng

  4. Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan, Taiwan

    Ching-Chi Chi

  5. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Ching-Chi Chi

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  1. Tao-Hsin Tung
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Contributions

T. H. Tung, ZLJ, and Y. H. Cheng collected the data and wrote the draft article. T. H. Tung calculated and interpreted the results and revised the manuscript. Y. H. Cheng and C. C. Chi designed the research process and content and reviewed the final version. All the authors have read and agreed to the published version of the manuscript.

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Correspondence to Yu-Hsien Cheng or Ching-Chi Chi.

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The authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

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Tung, TH., Jiesisibieke, Z.L., Cheng, YH. et al. Risk of breast cancer among patients with psoriasis: a systematic review and meta-analysis. Arch Dermatol Res 316, 12 (2024). https://doi.org/10.1007/s00403-023-02753-9

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  • DOI: https://doi.org/10.1007/s00403-023-02753-9

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