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HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population

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Abstract

To verify whether PsA-associated HLA alleles proposed in other populations are also related to PsA in Chinese Han population, a study of PsA susceptible alleles in the HLA-A, HLA-B, HLA-C and HLA-DRB1 alleles was presented for Chinese Han population. Genotyping was performed by Illumina Miseq platform (Illumina, USA). 50 subtypes and 77 subtypes of HLA-A, HLA-B, HLA-C and HLA-DRB1 with minor allele frequency (MAF) > 1% were genotyped from two-digit and four-digit resolution analysis in 111 PsA and 207 HCs (healthy controls) collected from Chinese Han population, respectively. Data handling, quality control and association analysis were performed using SPSS 25.0 software. In risk estimate, by mean of Bonferroni correction, a newfound four-digit allele HLA-A*01:01 [P = 5.5 × 10−4, OR 3.35 (1.69–6.66)], four-digit allele HLA-C*06:02 [P = 8.5 × 10−7, OR 3.80 (2.23–6.47)] and six two-digit alleles HLA-A*01 [P = 5.2 × 10−5, OR 3.43 (1.89–6.23)], HLA-B*13 [P = 4.0 × 10−6, OR 2.65 (1.76–4.01)], HLA-B*27 [P = 7.5 × 10−4, OR 5.84 (2.09–16.29)], HLA-B*57 [P = 5.8 × 10−5, OR 20.10 (4.65–86.83)], HLA-C*03 [P = 2.1 × 10−4, OR 0.40 (0.25–0.65)], HLA-C*06 [P = 1.9 × 10−12, OR 4.48 (2.95–6.81)] showed statistical significance by the univariate binary logistic regression analysis. Besides, in the binary logistic regression analysis with multiple variables, when the two alleles HLA-A*01:01 and HLA-C*06:02 were considered as covariates, HLA-A*01:01 [P = 2.7 × 10−3,OR 2.95 (1.46–5.98)] also showed significant association for PsA as risk factor, but may be not the main risk factor [HLA-C*06:02, P = 3.0 × 10−6, OR 3.68 (2.13–6.37)]. When all the above two-digit alleles were included as covariates, HLA-A*01 [P = 4.8 × 10−2, OR 2.00 (1.01–3.94)], HLA-B*13 [P = 4.2 × 10−5, OR 2.62 (1.65–4.16)], HLA-B*27 [P = 1.7 × 10−4, OR 7.62 (2.64–21.96)], HLA-B*57 [P = 2.97 × 10−4, OR 15.90 (3.55–71.18)], HLA-C*06 [P = 6.1 × 10−5, OR 2.70 (1.66–4.40)] showed significant for PsA as risk factors, HLA-C*03 [OR 0.65 (0.39–1.09), P = 0.10] showed no association with PsA. In conclusion, we assessed HLA-A, HLA-B, HLA-C and HLA-DRB1 alleles in PsA cohort of Chinese Han population, found HLA-A*01:01 and HLA-A*01 may be the susceptible genes associated with PsA, and also confirmed the association of four loci with PsA in Chinese Han population. These findings may extend the susceptibility HLA alleles of PsA and help in developing possible genetic markers to predict PsA.

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Abbreviations

PsA:

Psoriatic arthritis

PsC:

Cutaneous psoriasis

PsV:

Psoriasis vulgaris

GWAS:

Genome-wide association studies

HLA:

Human leucocyte antigen

MHC:

Major histocompatibility complex

HC:

Healthy control

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Acknowledgements

The authors benefited from the following research grants: National Natural Science Foundation of China (81273301, 81271747, 31671307). We are most grateful to the patients with PsA and the healthy controls who so willingly participated in this study. We greatly appreciate all the staff of our Institute of Dermatology for who contributed to this work.

Funding

National Natural Science Foundation of China (31671307, 81273301, 81271747).

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Authors and Affiliations

  1. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, China

    Jingjing Chen, Fan Yang, Yan Zhang, Xing Fan, Wenjun Qian, Yuling Chang, Xianbo Zuo, Xiaodong Zheng, Bo Liang, Yuanjing Zhang, Liangdan Sun, Sen Yang & Xuejun Zhang

  2. Institute of Dermatology, Anhui Medical University, Hefei, 230022, Anhui, China

    Jingjing Chen, Fan Yang, Yan Zhang, Xing Fan, Wenjun Qian, Yuling Chang, Xianbo Zuo, Xiaodong Zheng, Bo Liang, Yuanjing Zhang, Liangdan Sun, Sen Yang & Xuejun Zhang

  3. Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China

    Hui Xiao

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  1. Jingjing Chen
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Correspondence to Xing Fan.

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This study was approved by the Ethics Committee of AnHui Medical University, and conducted according to Declaration of Helsinki principles.

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Chen, J., Yang, F., Zhang, Y. et al. HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population. Arch Dermatol Res 311, 277–285 (2019). https://doi.org/10.1007/s00403-019-01902-3

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  • DOI: https://doi.org/10.1007/s00403-019-01902-3

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