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Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients

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Abstract

Purpose

This study aimed to evaluate the effect of the stoma on sexual function in colorectal cancer patients.

Methods

Search strategy was conducted in four databases including PubMed, Embase, the Cochrane Library, and Medline on Nov 20, 2022. After that, the quality of eligible studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). In order to evaluate the sexual function between the stoma group and the non-stoma group, mean values and standard deviation were pooled for scores in questionnaires, and odds ratio and 95% confidence intervals were pooled for self-designed problems. Results were shown in forest plots; Egger’s test and the trim and fill analysis were used for assessing the publication bias. All the data analyses above were performed by STATA 16.0 software.

Results

Six cohort studies and three cross-sectional studies were included for this pooling up analysis. As for the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C38), male patients with stomas had more sexual problems (mean differences = 0.32, 95% confidence intervals = 0.01 to 0.63, I2 = 67.80%, P = 0.05); however, other indicators including sexual functioning, sexual enjoyment, and female sexual problems had little difference between the two groups. As for other questionnaires and problems, stoma did not have an impact on sexual function.

Conclusion

The stoma after surgery was not significantly associated with the sexual function of female patients with colorectal cancer and was associated with worse scores on only sexual problems for males.

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Data availability

The data was accessed in the database.

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Acknowledgements

We acknowledge all the authors in this article.

Funding

This study was supported by the Program for Youth Innovation in Future Medicine, Chongqing Medical University.

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Author notes

  1. Xu-Rui Liu and Yue Tong are co-first authors.

Authors and Affiliations

  1. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Xu-Rui Liu, Yue Tong, Zi-Wei Li, Fei Liu, Xiao-Yu Liu, Wei Zhang & Dong Peng

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  1. Xu-Rui Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Zi-Wei Li, Fei Liu, Xiao-Yu Liu, and Wei Zhang. The first draft of the manuscript was written by Xu-Rui Liu and Tong Yue, the final draft of the manuscript was written by Dong Peng, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Dong Peng.

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The current study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

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Liu, XR., Tong, Y., Li, ZW. et al. Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients. Int J Colorectal Dis 38, 79 (2023). https://doi.org/10.1007/s00384-023-04372-2

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