Oncological colorectal surgery during the COVID-19pandemic—a national survey

Purpose The aim of this study was to clarify the surgical supply situation of oncological colorectal patients in Germany during limitations of the OR caseload due to the COVID-19 pandemic. Methods Between 11th and 19th April 2020, all members of a consortium of German colorectal cancer centers were invited to participate in a web-based survey on the current status of surgical care situation of colorectal cancer patients in Germany. Results A total of 112 colorectal surgeons of 101 German hospitals participated in the survey. Eighty-seven percent of the participating hospitals had to reduce their total surgical caseload and 34% their surgical volume for oncological colorectal patients during COVID-19 pandemic. Restrictions of the surgical caseload were independent of the size of the hospital and the number of cases of COVID-19 in the federal state of the hospital. Sixteen percent of colorectal surgeons consider surgical limitations to be not justified and 78% to be justified only if the care of oncological patients is ensured. Ninety-five percent of the colorectal surgeons interviewed stated that all oncological colorectal patients with an indication for surgery should be operated in time, despite the current reservations for COVID-19 patients. For the majority of the respondents (63% and 51%, respectively), an extended waiting time for surgery of up to 2 weeks was acceptable for non-metastatic and metastatic patients, respectively. Conclusion In Germany, there is a temporarily relevant reduction of surgical volume in oncological colorectal patients. Most colorectal surgeons stated that oncological colorectal surgery should not be compromised despite the measures taken during the COVID-19 pandemic.


Introduction
The COVID-19 pandemic has led to relevant changes in global health care systems, particularly in surgical disciplines [1,2]. In order to expand and maintain intensive care capacities for patients with SARS-CoV-2 infection, surgical caseload in German hospitals has been drastically reduced by German health authorities. This strategy aimed to mobilize staff for the intensive care units and to reduce the demand for postoperative intensive care unit beds. Although primarily elective non-oncological surgeries were no longer performed, oncological patients are increasingly affected by caseload restrictions in the OR [3]. Delays in the therapy of patients with colorectal cancer can lead to a deterioration of survival chances of these patients [4]. The effects of the current measures on oncological colorectal surgery in Germany and worldwide are not yet known. The aim of this national survey was therefore to investigate the current situation of surgical care of colorectal cancer patients and the opinion of German colorectal cancer surgeons on possible measures and therapy adjustments for colorectal cancer patients during the COVID-19 pandemic.

Methods
On April 11th 2020, an online survey using Google Forms (Google LLC, Menlo Park California, USA) was sent by email to all members of a consortium of German colorectal cancer centers (Arbeitsgemeinschaft der Deutschen Darmkrebszentren (ADDZ)). A reminder e-mail was sent to all members on April 16th, 2020. Participation was possible from April 11th, 2020 to April 19th, 2020.
For the subgroup analysis, participating hospitals were divided into federal states with a low and high frequency of COVID-19 cases. As a threshold value, 150 cases per 100,000 inhabitants were selected. The data on the number of COVID-19 cases per 100,000 inhabitants were taken from the Robert Koch Institute as of April 23rd, 2020. Federal states with over 150 cases per 100,000 inhabitants were Bavaria, Baden Württemberg, Hamburg, Saarland, and North Rhine-Westphalia. Tertiary referral hospitals were compared to all other hospitals. Additionally, hospitals were stratified according to their caseload per year using the median as threshold.
Data analysis was performed with SPSS software (version 24.0). Metric and ordinal data were compared using the Student's t test or Mann-Whitney U test. For categorical data, the Chi-square test was used. The threshold for statistical significance was p < 0.05.

Results
A total of 112 colorectal surgeons from 101 German hospitals took part in this survey-including 42 tertiary referral hospitals (24 university hospitals, 18 non-university hospitals) and 59 other hospitals (mostly with a colorectal focus (n = 48)). The response rate in federal states with a high number of COVID-19 cases was significantly higher than in states with a low number of COVID-19 cases (p = 0.047) (Fig. 1). The average number of colorectal surgery cases of the participating hospitals was 123 cases per year with a range of 4 to 350 cases per year (Table 1).
Eighty-seven percent of the participating hospitals had to reduce their total OR volume due to the COVID-19 pandemic. The remaining caseload corresponded to ≤ 20% of the pre-pandemic surgical capacity in 10% of the hospitals, 21-40% in 37%, 41-60% in 28%, 61-80% in 11%, and 81-99% in 2%. Regarding oncological colorectal surgery, 34% of the participating hospitals had a reduced surgical caseload-6% of the hospitals had a remaining surgical volume of ≤ 20%, 8% of 21-40%, 9% of 41-60%, 9% of 61-80%, and 2% of 81-99%. There was no difference between tertiary referral and other hospitals and hospitals in federal states with high and low numbers of COVID-19 patients, both for the total surgical caseload limitations and for the surgical volume restrictions for oncological colorectal surgery ( Table 2). The majority (78%) of the participating colorectal surgeons stated that the limitations in surgical capacities are only justified as long as the care of oncological patients is ensured. For 16% of those questioned, the limitations of the surgical capacity are not justified (Table 3).
Ninety-four percent of the participating hospitals operate on patients with SARS-CoV-2 infection at their hospital and 6% transfer those patients to specialized centers. A preoperative test for COVID-19 is always performed in 20% of the hospitals, while 50% of the hospitals test for symptoms and 31% do not perform preoperative COVID-19 tests. The preferred test method is the detection of SARS-CoV-2 by PCR; one clinic performs a thoracic CT-scan for COVID-19 detection (Table 2).
There are further consequences of the COVID-19 pandemic: 45% of the participating hospitals lack protective materials    (masks, gowns), while hospitals with maximum care are significantly less affected (p = 0.008). A few hospitals (8%) suffer from a lack of surgical materials such as staplers.
Interdisciplinary tumor boards are carried out in 70% of the hospitals with fewer staff and in 39% of the hospitals by video conference (Table 2). Two thirds of all respondents stated that the measures taken for German hospitals during the COVID-19 pandemic are appropriate, but one third said they were too much. In comparison, measures in social life are considered as appropriate by 80% of respondents, 16% as too much, and 4% as too little ( Table 3).
Assessment of statements and potential adjustments in therapy of oncological colorectal patients is shown in Table 4: 6 of 15 statements achieved a high, 3 a moderate, and 6 a low level of agreement.
Highest agreement (95%) was achieved for the statement, that all oncological colorectal patients with an indication for surgery should not be postponed, despite the current OR volume reductions. For the majority of the respondents (63% and 51%, respectively), an extended waiting time for surgery of up to 2 weeks for non-metastatic, respectively, metastatic patients was acceptable, whereas 37% and 49%, respectively, did not consider additional waiting time appropriate for oncological colorectal patients.
There were three statements with low agreement that showed differences in the sub-group analysis: hospitals with a high number of colorectal surgery cases disagreed significantly more often with the statement that during the COVID-19 pandemic, the use of a surgical robot should be avoided to optimize OR capacity (60% vs. 44%, p = 0.022). Treatment of COVID-19-positive patients with colorectal cancer in specialized centers was advocated significantly more often by tertiary referral hospitals and hospitals in federal states with a high frequency of COVID-19 cases (67% vs. 24%, p < 0.001; 51% vs. 27%, p = 0.045). Colorectal experts from federal states with a high frequency of COVID-19 cases voted significantly more often for the use of colorectal surgeons in the intensive care of COVID-19 patients (43% vs. 22%, p = 0.038).

Discussion
The COVID-19 pandemic has had a major impact on health care systems worldwide, leading to relevant caseload restrictions in general surgery, including colorectal cancer surgery. Hospitals were faced to a need of reorganization of their clinical practice. Important challenges included prioritization of surgical interventions, establishment of SARS-CoV-2 and non-SARS-CoV-2 emergency rooms, establishment of a SARS-CoV-2 surgical non-intensive care ward, establishment of a surgical SARS-CoV-2 operating area, and necessary precautions when using certain surgical techniques [2].
There are few reports from individual hospitals, particular from Italy, on strategies for colorectal surgery practice during the COVID-19 pandemic [3,[5][6][7][8]. It remains unclear how the COVID-19 pandemic affects the care of patients with colorectal cancer. In this regard, surveys may help to improve the limited evidence by providing a snapshot of current clinical practice and subsequently supporting clinical decisionmaking [9].
This nationwide survey reveals that health policy measures to save resources by reducing the overall number of surgeries during the COVID-19 pandemic also affect oncological colorectal resections in 34% of the hospitals. This fact is considered critical by the majority of interviewed colorectal surgeons. Regarding the treatment of oncological colorectal patients during the COVID-19 pandemic, the majority of the German surgeons surveyed plead for timely surgery with a maximum extension of the waiting period of 2 weeks and for compliance with national and international guidelines. However, questions remain open for discussion, in particular whether colorectal surgery for patients with SARS-CoV-2 infection should be performed in specialized centers and to what extent colorectal surgeons should be recruited for the ICU therapy of COVID-19 patients.
Of course, the care of oncological colorectal patients can vary from country to country, especially since Germany seems to be less affected by the COVID-19 pandemic than other nations according to the data from the Johns Hopkins Institute. Nevertheless, in times of scarce resources, an ethical discourse should be held on the extent to which a potential deterioration in the prognosis of oncological patients is justified for the care of other diseases in a highly developed industrial country.

Conclusion
In Germany, health policy measures to save resources during the COVID19 pandemic led to a temporarily relevant reduction of surgical volume that affects oncological colorectal patients. Most of the participating German colorectal surgeons recommended that oncological colorectal surgery should not be compromised despite the measures taken during the COVID-19 pandemic.
Code availability Data analysis was performed with SPSS software (version 24.0).

Funding information Open Access funding provided by Projekt DEAL.
Data availability The manuscript including tables and figure contain all data.

Compliance with ethical standards
Conflict of interest The authors declare that they have no conflict of interest.
Ethics approval As the present study is a survey, there is no need for ethical approval.
Consent to participate This study contains no information that would enable individual patient identity.
Consent for publication All authors have read and approved the manuscript.
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