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Sarcopenia is associated with an increased risk of advanced colorectal neoplasia

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background/aims

Although sarcopenia is associated with an increased risk for mortality after the curative resection of colorectal cancer, its influence on the development of advanced colonic neoplasia remains unclear.

Methods

This study included 1270 subjects aged 40 years or older evaluated with first-time screening colonoscopy at Seoul National University Boramae Health Care Center from January 2010 to February 2015. Skeletal muscle mass was measured with a body composition analyzer (direct segmental multifrequency bioelectrical impedance analysis method). Multiple logistic regression analysis was performed to determine whether sarcopenia is associated with advanced colorectal neoplasia.

Results

Of 1270 subjects, 139 (10.9%) were categorized into the sarcopenia group and 1131 (89.1%) into the non-sarcopenia group. In the non-sarcopenia group, 55 subjects (4.9%) had advanced colorectal neoplasia. However, in the sarcopenia group, 19 subjects (13.7%) had advanced colorectal neoplasia, including 1 subject with invasive colorectal cancer (0.7%). In addition, subjects with sarcopenia had a higher prevalence of advanced adenoma (P < 0.001) than those without sarcopenia. According to the multiple logistic regression analysis adjusted for variable confounders, age (odds ratio 1.062, 95% confidence interval 1.032–1.093; P < 0.001), male sex (odds ratio 1.749, 95% confidence interval 1.008–3.036; P = 0.047), and sarcopenia (odds ratio 2.347, 95% confidence interval 1.311–4.202; P = 0.004) were associated with an advanced colorectal neoplasia.

Conclusion

Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

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Acknowledgements

All authors were involved in critical revision of the paper for important intellectual content and have approved the final draft submitted. The authors gratefully acknowledge the invaluable assistance of the endoscopists from Seoul National University Boramae Health Care Center.

Author contribution

Guarantor of the article: Koh SJ; Park YS and Kim JW equally contributed to this article; specific author contributions: data collection, data analysis, and writing of the manuscript: Park YS, MD, Kim JW, and Koh SJ; data collection: Kim BG, Lee JK, and Kim JS; data analysis: Lee KL.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 5 Gil 20, Boramae-Road, Dongjak-Gu, Seoul, 156-707, South Korea

    Youn Su Park, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jae Kyung Lee & Seong-Joon Koh

  2. Department of Internal Medicine and Liver Research Institute, Seoul National University, Seoul, 110-744, South Korea

    Joo Sung Kim

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  1. Youn Su Park
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  2. Ji Won Kim
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Correspondence to Seong-Joon Koh.

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Youn Su Park and Ji Won Kim equally contributed to this article.

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Park, Y.S., Kim, J.W., Kim, B.G. et al. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia. Int J Colorectal Dis 32, 557–565 (2017). https://doi.org/10.1007/s00384-016-2738-8

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  • DOI: https://doi.org/10.1007/s00384-016-2738-8

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