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The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits

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Abstract

Takotsubo cardiomyopathy (TCM) has been reported to occur after subarachnoid hemorrhage, and the involvement of a critical activity of catecholamines has been mentioned, but the details of its onset have not been fully clarified. Recently, proper arterial stiffness could be measured with cardio-ankle vascular index. Therefore, we aimed to clarify the role of arterial stiffness in onset of TCM using rabbits under infusion of noradrenaline and injection of blood into brain ventricle. Rabbits were divided into three groups: infusion of noradrenaline (group A), infusion of noradrenaline + injection of saline into the brain ventricle (group B), infusion of noradrenaline + injection of blood in the brain ventricle (group C). Aortic arterial stiffness beta (Aβ) and femoral arterial stiffness beta (Fβ) were defined according to definition of the cardio-ankle vascular index. Blood pressure (BP), Aβ, Fβ, and femoral vessel resistance (FVR) were measured. Left ventricular movement were monitored with echocardiography. BP increased uniformly in all three groups. Fβ in the group A, B and C increased from 3.6 ± 3.2, 3.6 ± 3.6 and 3.9_ ± 4.2 to 15 ± 2, 17.9 ± 2.4, 34.8 ± 9.1 due to the ICP enhancements in addition to noradrenaline administration, respectively. Fβ in groups B and C was significantly larger than that in group A. On echocardiography, a much higher akinesic area of the apex was observed in group C compared with group A and B. Cardiac movements similar to TCM were observed slightly in group B and definitely in group C. Noradrenaline administration infusion and blood injection into the brain ventricle induced TCM accompanying with enhanced femoral arterial stiffness. These results suggested that elevated arterial stiffness might be involved in the formation of TCM in addition to a critical activity of catecholamines and an increase in intracranial pressure with blood injection.

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Abbreviations

TTS:

Takotsubo syndrome

PWV:

Pulse wave velocity

CAVI:

Cardio-ankle vascular index

Aβ:

Aortic arterial stiffness beta

Fβ:

Femoral arterial stiffness beta

ICP:

Intracranial pressure

BP:

Blood pressure

CM:

Cisterna magna

FVR:

Femoral vascular resistance

LV:

Left ventricle

ANOVA:

One-way analysis of variance

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Acknowledgements

Fukuda Denshi Co., Ltd., Tokyo, Japan donated one VaSera 1500 system device to the Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University for research purposes, but was not involved in any way in the design, execution, or analysis of this study nor the preparation of the article.

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Authors and Affiliations

  1. Department of Cardiology, Sakura Hospital, Medical Center, Toho University, Chiba, Japan

    Mao Takahashi & Shuji Sato

  2. Tokyo Kamata Medical Center, Minamikamata, Ootaku, Tokyo, 2-19-2, Japan

    Chikao Miyazaki & Kazuhiro Shimizu

  3. Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan

    Cao Xin, Tatsuo Chiba, Megumi Aimoto, Yoshinobu Nagasawa & Akira Takahara

  4. Department of Ophthalmology, Toho University, School of Medicine, Tokyo, Japan

    Tetsuya Komatsu

  5. Department of Medical Informatics, Toho University School of Medicine, Tokyo, Japan

    Hisayuki Tsukuma & Kohji Shirai

  6. Mihama Hospital, Japan, Chiba

    Mao Takahashi, Chikao Miyazaki, Cao Xin, Shuji Sato, Kazuhiro Shimizu, Tatsuo Chiba, Hisayuki Tsukuma, Tetsuya Komatsu, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara & Kohji Shirai

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  1. Mao Takahashi
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  2. Chikao Miyazaki
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  11. Akira Takahara
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Corresponding author

Correspondence to Chikao Miyazaki.

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Conflict of interest

AT receives research support from Fukuda Denshi Co., Ltd. The remaining authors have no conflicts of interest to declare.

IRB information

All animal work was performed according to NIH guidelines. Experimental procedures were approved by the Toho University Animal Care and User Committee (approval number: 19-53-360).

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Takahashi, M., Miyazaki, C., Xin, C. et al. The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits. Heart Vessels 38, 740–748 (2023). https://doi.org/10.1007/s00380-022-02223-8

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  • DOI: https://doi.org/10.1007/s00380-022-02223-8

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