Abstract
This research aimed at fabrication of baghdadite scaffolds with chitosan coating via combining of polymeric sponge replication and dip-coating methods with improved mechanical and biological properties. The composite was characterized using x-ray diffraction, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Porosity, compressive strength, in vitro bioactivity and biological responses of human bone marrow mesenchymal stem cells were evaluated. The porosity percentage and compressive strength values were 79 ± 0.87 and 2.88 ± 0.34, respectively. The results showed chitosan coating could largely enhance the mechanical strength of baghdadite scaffolds. Also apatite-like layer formation was observed. Based on the MTT assay and SEM micrographs, human bone marrow mesenchymal stem cells were spread and attached well on the surface of the scaffold, which indicated a high biocompatibility. The results showed that this composite scaffold has the potential to be used as a temporary substrate for bone tissue engineering applications.
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Abbasi Soureshjani, F., Nilforoushan, M.R., Sharifi, H. et al. Improvement in mechanical and biological performance of porous baghdadite scaffold by applying chitosan coating. Appl. Phys. A 127, 335 (2021). https://doi.org/10.1007/s00339-021-04475-z
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DOI: https://doi.org/10.1007/s00339-021-04475-z