Abstract
Objectives
To predict sentinel lymph node (SLN) metastasis in breast cancer patients using radiomics based on T2-weighted fat suppression (T2-FS) and diffusion-weighted MRI (DWI).
Methods
We enrolled 146 patients with histologically proven breast cancer. All underwent pretreatment T2-FS and DWI MRI scan. In all, 10,962 texture and four non-texture features were extracted for each patient. The 0.623 + bootstrap method and the area under the curve (AUC) were used to select the features. We constructed ten logistic regression models (orders of 1–10) based on different combination of image features using stepwise forward method.
Results
For T2-FS, model 10 with ten features yielded the highest AUC of 0.847 in the training set and 0.770 in the validation set. For DWI, model 8 with eight features reached the highest AUC of 0.847 in the training set and 0.787 in the validation set. For joint T2-FS and DWI, model 10 with ten features yielded an AUC of 0.863 in the training set and 0.805 in the validation set.
Conclusions
Full utilisation of breast cancer-specific textural features extracted from anatomical and functional MRI images improves the performance of radiomics in predicting SLN metastasis, providing a non-invasive approach in clinical practice.
Key Points
• SLN biopsy to access breast cancer metastasis has multiple complications.
• Radiomics uses features extracted from medical images to characterise intratumour heterogeneity.
• We combined T 2 -FS and DWI textural features to predict SLN metastasis non-invasively.
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Abbreviations
- ALN:
-
Axillary lymph node
- AUC:
-
Area under the curve
- DWI:
-
Diffusion-weighted MRI
- ER:
-
Oestrogen receptor
- PR:
-
Progesterone receptor
- SLN:
-
Sentinel lymph node
- T2FS:
-
T2-weighted fat suppression
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The scientific guarantor of this publication is Shuixing Zhang.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Funding
This study has received funding by the National Scientific Foundation of China (81571664), the Science and Technology Planning Project of Guangdong Province (2014A020212244, 2016A020216020, 2015B010131011) and The Science and Technology Project of Guangdong Province (2015B010131011).
Statistics and biometry
One of the authors has significant statistical expertise.
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Written informed consent was waived by the institutional review board.
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Institutional review board approval was obtained.
Methodology
• retrospective
• diagnostic or prognostic study
• performed at one institution
Additional information
Yuhao Dong, Qianjin Feng and Wei Yang contributed equally to this work.
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Dong, Y., Feng, Q., Yang, W. et al. Preoperative prediction of sentinel lymph node metastasis in breast cancer based on radiomics of T2-weighted fat-suppression and diffusion-weighted MRI. Eur Radiol 28, 582–591 (2018). https://doi.org/10.1007/s00330-017-5005-7
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DOI: https://doi.org/10.1007/s00330-017-5005-7