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Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer

  • Gastrointestinal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To explore the correlations between DCE-MRI quantitative parameters and synchronous distant metastasis and the clinicopathological factors in rectal cancers.

Methods

Sixty-three patients with rectal cancer (synchronous distant metastasis, n = 31; non-metastasis, n = 32) were enrolled in this study. Student’s t test and ANOVA were used to compare DCE-MRI parameters (K trans, K ep and V e ). The receiver operating characteristic (ROC) analysis was used to find the reasonable threshold of DCE-MRI parameters to differentiate lesions with synchronous distant metastasis from those without metastasis.

Results

The K trans, K ep , and V e value were significantly higher in the lesions with distant metastasis than in the lesions without distant metastasis (0.536 ± 0.242 vs. 0.299 ± 0.118 min-1, p < 0.001; 1.598 ± 0.477 vs. 1.341 ± 0.390 min-1, p = 0.022; and 0.324 ± 0.173 vs. 0.249 ± 0.091, p = 0.034; respectively). The K trans showed the highest AUCs of 0.788 (p < 0.001), with sensitivity of 61.29 % and specificity of 87.5 %, respectively.

Conclusions

DCE-MRI parameters may represent a prognostic indicator for synchronous distant metastases in patients with rectal cancer.

Key Points

• The K trans , K ep and V e values correlated with synchronous distant metastasis.

• Higher K trans , K ep and V e values were noted among patients with metastasis.

• DCE-MRI parameters might represent a prognostic indicator for synchronous distant metastases.

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Abbreviations

AUC:

Area under the curve

CEA:

Carcinoembryonic antigen

DCE-MRI:

Dynamic contrast-enhanced magnetic resonance imaging

EES:

Extravascular-extracellular space

k ep :

Rate constant from EES to blood plasma (min-1)

K trans :

Volume transfer constant between EES and blood plasma (min-1)

LVI:

Lymphovascular invasion

ROC:

Receiver operating characteristic

V e :

EES volume per unit tissue volume

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Acknowledgements

The scientific guarantor of this publication is Hai-Bin Shi. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational, performed at one institution.

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    Authors and Affiliations

    1. Department of Radiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China

      Jing Yu, Qing Xu, Jia-Cheng Song, Yan Li, Lu-Lu Xu & Hai-Bin Shi

    2. Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

      Dong-Ya Huang

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    1. Jing Yu
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    Correspondence to Hai-Bin Shi.

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    Jing Yu and Qing Xu contributed equally to this work.

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    Yu, J., Xu, Q., Huang, DY. et al. Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer. Eur Radiol 27, 1840–1847 (2017). https://doi.org/10.1007/s00330-016-4532-y

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