Abstract
The safety of a new technique, designated “transcatheter arterial embolization (TAE) with aspiration via a balloon-occluded renal drainage vein” (TAE-ABOD), for the management of large renal cell carcinomas (RCCs). The subjects were 25 patients with RCC who underwent a total of 27 sessions of TAE-ABOD. This TAE-ABOD technique incorporates two procedures: balloon occlusion of renal drainage vein and infusion of absolute ethanol into the tumor-feeding arteries during aspiration of blood via a balloon catheter, thereby reducing leakage of absolute ethanol into the systemic circulation. Our primary endpoint was to establish a safe regimen for high-dose ethanol injection therapy, and our secondary endpoint was to assess global survival of the patients. The administered dose of ethanol ranged from 0.2 to 0.5 ml/kg [median: 0.34 (SD: 0.10) ml/kg], increased in a stepwise manner. The systemic ethanol concentration was measurable in 14 patients, and was less than 0.1 mg/ml in 12 and from 0.1 to less than 0.2 mg/ml in two. There were no major complications such as renal failure or renal abscess. TAE-ABOD can safely deliver a high dose of absolute ethanol for the treatment of large RCCs.
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Acknowledgements
This study was supported by a grant from the Third Term Comprehensive Control Research for Cancer, the Program for Promotion of Fundamental Studies in Health Sciences of the Organization for Pharmaceuticals and Medical Devices Agency (PMDA) and the Grant-in-Aid for Cancer Research (1, 14–5) from the Ministry of Health, Labour and Welfare.
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Murata, S., Tajima, H., Onozawa, S. et al. Pilot study of transcatheter arterial ethanol embolization under closed renal circuit for large renal cell carcinomas. Eur Radiol 18, 1464–1472 (2008). https://doi.org/10.1007/s00330-008-0895-z
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DOI: https://doi.org/10.1007/s00330-008-0895-z