Functional limitations of people with rheumatoid arthritis or axial spondyloarthritis and severe functional disability: a cross-sectional descriptive study

The objective of the study is to describe the nature of functional limitations in activities and participation in people with Rheumatoid Arthritis (RA) or axial SpondyloArthritis (axSpA) with severe functional disability. Baseline data from people with RA (n = 206) or axSpA (n = 155) and severe functional disability participating in an exercise trial were used. Their three most limited activities were derived from the Patient Specific Complaint (PSC) instrument and linked to the International Classification of Functioning and Health (ICF). The frequencies of ICF categories were calculated and compared with Activities and Participation items of the ICF Core Sets for RA (32 second-level categories) and Ankylosing Spondylitis (AS) (24 second-level categories). In total 618 and 465 PSC activities were linked to 909 (72 unique in total; 25 unique second-level) and 759 (57 unique in total; 23 unique second-level) ICF categories in RA and axSpA. Taking into account all three prioritized activities, the five most frequent limited activities concerned the ICF chapter “Mobility”, and included “Walking” (RA and axSpA 2 categories), “Changing basic body position” (RA and axSpA 1 category), “Stair climbing”(RA) and “Grasping” (RA),“Lifting” (axSpA) and “Maintaining a standing position” (axSpA). In RA, 21/32 (66%) and in axSpA 14/24 (58%) unique second-level categories identified in the prioritized activities are present in the Comprehensive Core Sets. Most limitations of people with RA or axSpA and severe functional disability were seen in the ICF chapter “Mobility”. Most of the identified ICF categories were covered by the corresponding items of the ICF RA and AS Core Sets. Supplementary Information The online version contains supplementary material available at 10.1007/s00296-023-05487-z.


Introduction
Rheumatoid Arthritis (RA) and axial SpondyloArthritis (axSpA) are two prevalent forms of Inflammatory Arthritis (IA) and can both have a major impact on physical functioning, including limitations in daily activities and participation [1,2].The treatment consists of pharmacological and non-pharmacological interventions, with significant advancements in the pharmacological treatment options in recent decades [3,4].However, a subgroup of people with RA/axSpA has suboptimal treatment outcomes, which is reflected in the recent recognition of difficult-to-treat RA [5].Some people with RA/axSpA still face severe functional disability despite optimal pharmacological treatment, stemming from joint damage accumulated over time, comorbidities or other health problems related to their rheumatic condition.
The optimal treatment of RA/axSpA requires shared decision-making between patients and clinicians, with goal-setting playing a crucial role [6,7].Literature on patient centered care emphasizes that treatment should address not only disease activity but also patients' functional limitations [6,7].A cross-sectional study, involving people with RA, found that 62% of the patient-clinician pairs achieved concordance on prioritization of the treatment goal "have fewer problems doing daily activities" [8].This highlights the importance of considering patients' functional limitations when setting treatment goals.Despite the importance of addressing and prioritizing functional limitations as a treatment goal, there is limited literature on this topic.A systematic literature review, including 22 studies on treatment goal-setting for people with RA, identified functional limitations as a common theme within the physical experience of RA [9].Goals on functional limitations included bending, engaging in physical activities and mobility [9].However, none of the studies in that systematic review specifically included patients with severe functional disability.Such patients are likely to be represented in rehabilitation settings.In one study, a cross-cultural comparison between four countries of the contents of rehabilitation goals of people with RA admitted for rehabilitation was made [10].In this, the rehabilitation goals were linked to the International Classification of Functioning, Disability and Health (ICF) [11] and ICF Core Set for RA [12], which includes the list of essential categories relevant to this specific health condition and health care context.It was found that most treatment goals were related to the ICF component "Activities and Participation" and fell within the chapters of "Mobility", "Self-care", and "Learning and applying knowledge" [10].The contents of the rehabilitation goals were, to a considerable extend, covered by the Comprehensive ICF Core Set for RA [10].However, the generalizability of the results to the current populations of people with RA/axSpA and severe functional disability may be limited [10].This study was conducted ten years ago, in which (pharmacological) treatments have evolved and are more treat-to-target, the methods used to achieve treatment goals differed between countries and data are only available from people with RA.
Nowadays in the Netherlands, most people with RA/ axSpA and severe functional disability requiring rehabilitative care are treated in primary care, with physical therapy being the most used intervention.
Currently, there are instruments available for goal-setting in treatment, such as an instrument developed for people with RA and clinicians [8].Additionally, several goalsetting instruments suitable for rehabilitation settings have been evaluated in people with RA as well.These include the Rehabilitation Activities Profile (RAP) [13], the Canadian Occupational Performance Measure (COPM) [14], and the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) [15].
Within the Dutch physical therapy community, the Patient Specific Complaint instrument (PSC) [16][17][18][19][20] is currently recommended.With the PSC, limitations in activities are identified and prioritized.The three highest ranked (and potentially modifiable) limitations in activities are scored on a 11-point numeric rating scale (anchors 0; no limitations-10; unable to perform) allowing evaluation over time [16][17][18].
Considering the limited knowledge regarding the nature of functional limitations of people with RA/axSpA and severe functional disability receiving physical therapy in primary care, this study aims to describe functional limitations in activities and participation of this subpopulation using the ICF as a reference.Insight into their prioritized functional limitations could facilitate the setting of treatment goals for daily activities.

Study design
This cross-sectional study concerns a descriptive analysis of the baseline data of two parallel randomized controlled trials (RCTs) investigating the effect of longstanding exercise therapy in primary care in people with RA or axSpA and severe functional disability (International Clinical Trials Registry Platform (ICTRP): Longstanding EXercise Therapy in patients with Rheumatoid Arthritis (L-EXTRA; NL8235) and Longstanding EXercise therapy in patient with axial SPondyolArthritis (L-EXSPA; NL8238)).All patients signed a written informed consent form and both studies were conducted in agreement with the Declaration of Helsinki (2013) [21].The ethical approval was granted by the Medical Ethical Committee Leiden-Den Haag-Delft (METC LDD; L-EXTRA: NL69866.058.19,L-EXSPA: NL70093.058.19).Details of both studies were published previously [22].For this analysis, baseline data from the included patients available on 14 February 2022 were used.The study was reported according to The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting cross-sectional studies.

Participants
The inclusion and exclusion criteria of the RCTs have been published previously [22].In brief, severe functional disability was defined as having self-perceived problems in performing basic activities of daily life (e.g.walking, dressing, washing oneself, using the toilet, preparing a meal, transfers).The problems should be related to their rheumatic condition, e.g.being due to persistent high disease activity, joint damage and/or deformities, complications of treatment, or co-morbidity.After patients had shown interest in the study, the presence of severe functional disability was to be confirmed during a structured telephone interview with one of the researchers (MT or MvW).In case of doubt, cases were presented and discussed in a larger team of researchers and clinicians to make the final decision on eligibility.If needed, additional information was requested from the patient or treating rheumatologist.After the screening, the treating rheumatologist was asked to confirm the diagnosis RA/axSpA of all eligible participants.

Sociodemographic and disease characteristics
The baseline sociodemographic and disease characteristics were collected using a patient self-reported questionnaire containing questions on age (years), sex (male/female/ other), body mass (kg), and length (meters) to calculate the body mass index (BMI), current medication use nonsteroidal anti-inflammatory drugs (NSAIDs), any diseasemodifying anti-rheumatic drug (DMARD) (categorized into conventional DMARD, biologic DMARD, targeted synthetic DMARD), or no anti-rheumatic medication or anti-inflammatory medication used), self-reported symptom duration (years), number of joint replacements, education level (low: primary school or pre-vocational secondary education; medium: senior general secondary education or pre-university education or secondary vocational education; high: Bachelor or Master at University (of Applied Sciences)) and, if 66 years or younger, having a paid job (yes/ no).Comorbidities were recorded based on a questionnaire developed by Statistics Netherlands, asking for the presence of 19 different comorbidities (yes/no) [23].Moreover, we requested the treating rheumatologist to provide measures of disease activity in terms of the Disease Activity Score 28 (DAS-28) for RA and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for axSpA.These measures were collected as close as possible to the date of the participant's enrollment in the study.All baseline data were tested for normality using the Kolmogorov-Smirnov or similar test, where appropriate.

Physical functioning measures
Physical functioning was measured using three different questionnaires: the Patient-Reported Outcomes Measurement Information System-Physical Function item bank 10 (PROMIS PF-10) [24] was used in both populations, the Health Assessment Questionnaire-Disability Index (HAQ-DI) [25] in people with RA and the Bath Ankylosing Spondylitis Functional Index (BASFI) in people with axSpA [26].
The PROMIS PF-10 [24] comprises ten questions from the PROMIS physical function item bank, which all are scored on a five-point scale ranging from 1 to 5 with higher scores indicating better physical functioning.The total score was calculated by uploading the data into a scoring system program [27], after which the T scores are calculated.The PROMIS PF-10 can range from 13.5 to 61.9 [28], where a higher score indicates better physical functioning.A validated Dutch version was used and, calculations of T scores were standardized to the Dutch population [29].
The HAQ-DI [25] contains 20 items concerning the ability to perform daily activities, divided over eight domains.There are four possible responses and corresponding scores for each question (without any difficulty; score = 0, with some difficulty; score 1, with much difficulty score = 2, and unable to do score = 3).The highest score reported by the patient for any component question in each domain determines the score for that domain.A validated Dutch translation of the HAQ-DI was used [30].The total HAQ-DI score was calculated by the sum of the scores of the eight domains divided by eight, after correcting for the use of aids or devices [25].While there is no data evidence as to what constitutes mild, moderate, or severe disability, a score of ≤ 1.0 is regarded as indicating mild disability, and a score ≥ 2.0 is considered to indicate severe disability [31].
The BASFI is a validated instrument to assess the degree of functional limitation in patients with Ankylosing Spondylitis [26].It consists of ten questions related to activities of daily living (eight on physical functioning and two on coping with everyday life), which are all scored on a 11-point scale ranging from 0 (easy) to 10 (impossible to perform) with higher scores indicating worse physical functioning.The mean of the individual scores is calculated to give the overall BASFI score ranging from 0 (no impairment) to 10 (severe impairment), with higher scores indicating more functional limitations [26].A Dutch translation of the BASFI was used.

Patient specific complaints instrument (PSC)
The PSC is a validated instrument in people with chronic diseases to identify and quantify limitations in activity [16][17][18].It was administered face-to-face by a trained researcher (MvW, MT).Patients were asked to describe three activities in daily life that were currently difficult to perform and found important to improve.Thereafter, the three PSC activities were prioritized by the patients from most important to least important.Subsequently, the patient was asked to score each of the activities on an 11-point numeric rating scale (NRS) (Anchor 0: able to perform activity without any problems; 10: unable to perform activity).As half of the participants would be randomized to a control condition, participants were not asked to formulate the limited activity in terms of a treatment goal, but only in terms of limited activities they desired to improve.

ICF linking method
The PSC activities were linked to the ICF following standardized linking rules [32,33].The linking process is shown in Fig. 1.Prior to the linking process, the researchers individually acquired knowledge of the conceptual fundamental elements of the ICF, components, chapters, categories of the detailed level classification, and definitions.Since the PSC pertains to daily activities, the linking was only done for the ICF component "Activities and Participation".The Dutch translation of the ICF as published on the WHO website was used for the linking process (https:// www.whofic.nl/ famil ie-van-inter natio nale-class ifica ties/ refer entie-class ifica ties/ icf accessed 1 November 2022).
In addition to the standardized linking rules proposed by Cieza et al. [32,33], five practical agreements were formulated to facilitate unambiguous definition of concepts and linking to ICF, which are shown in the Supplemental material.
Two researchers (MT and TD) independently performed all steps of the linking process.In case of disagreements between the two researchers, a third researcher (SvW) was consulted.In the first step, each PSC activity was divided into (multiple) relevant meaningful concepts.For example, the PSC activity: "Walking about 3000 m to the supermarket to shop groceries" was divided into two meaningful concepts: "Walking long distances" and "Shopping".Parts of the PSC activity that could not be assigned to a meaningful concept were registered separately to prevent a loss of information.Subsequently, all identified meaningful concepts were linked to the most specific ICF category within the "Activities and Participation" component, with the first level and, where applicable, the second-level category and the third-level category representing increasingly more specific information.For example, the meaningful concept "Cycling" was linked within the first-level category (chapter) "Mobility" and the second-level category "Driving" and to the third-level category "Driving human-powered transportation".
For the determination of the overlap with ICF Core sets, a comparison with the categories in the component "Activities and Participation" of the ICF Core Set for RA [12] and ICF Core Set for Ankylosing Spondylitis (AS) [34] was made.The ICF categories in the ICF RA and AS Core Sets are all defined at the second level.To enable a comparison between the content of the identified PSC activities and the content of the Core Sets, for the activities with a third-level ICF category, the corresponding second-level categories were used.If no ICF category was appropriate within the "Activities and Participation" component but rather another component of the ICF, this meaningful concept was assigned as "not defined in Activities and participation (nd-ap)".For example, if a PSC activity was "Looking over the shoulder when changing direction while riding a bicycle", the meaningful concept "Rotating the neck" was linked to the category nd-ap since the most appropriate ICF category was "Mobility of bone functions, specified".

Analyses
For this analysis, we utilized baseline data from the included patients available on February 14, 2022.As of that date, the inclusion of participants in the studies was still ongoing.The target enrollment for both RCTs was set at 215 participants.Given the descriptive design of this study, in which we wanted to describe the nature of functional limitations no supplementary power calculations were performed.A minimum number of 150 patients per diagnosis group was considered sufficient to estimate both low and high frequencies of specific limitations with sufficient precision.We included all available data at the moment of the analysis as we considered it unethical to leave individuals out [35].Descriptive analyses of the baseline characteristics were done for people with RA or axSpA separately.
For both populations, the total numbers of meaningful concepts and the numbers and frequencies of unique ICF categories were calculated in total and for each of the three ranked PSC activities separately.In addition, the mean number of ICF categories per PSC activity per participant were calculated.Finally, the overlap with the Comprehensive and Brief ICF Core Sets for RA and AS was determined by comparing the Core Set items to the uniquely identified second-level ICF categories derived from the PSC activities.All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS), Released 2017, IBM SPSS Statistics for Windows, Version 25.0.Armonk, NY, United States of America: IBM Corp.

Demographics and disease characteristics
Table 1 shows the baseline characteristics of the 206 and 155 participants with RA or axSpA with all of the data being normally distributed.Their mean ages (SD) were 58.7 (12.9) and 53.2 (11.8) years), the proportion of females was 90.8% and 47.1% and the self-reported symptom duration was 21.6 (13.5) and 24.7 (14.4) years) in the RA and axSpA groups, respectively.More than 70% of both RA and axSpA groups had three or more comorbidities.

Number of identified meaningful concepts derived from PSC, and total and unique ICF categories
Results are shown in Table 2.In total 911 and 769 meaningful concepts were identified from the PSC activities for people with RA and axSpA, respectively.These were linked to 909 and 759 ICF categories, of which 72 and 57 were unique in RA and axSpA, respectively.All uniquely identified ICF categories were on the second-level (n = 5 in RA and n = 4 in axSpA) or third-level (n = 67 in RA and n = 53 in axSpA).When all meaningful concepts were only linked to second-level categories, there were 25 and 23 unique ICF categories for RA and axSpA, respectively.There were two meaningful concepts in RA and ten in axSpA that could not be linked to an ICF category within the component "Activities and Participation" but within the component "Body functions" and were thus assigned to the "nc-ap" category.

Type and frequency of ICF categories
The total numbers of identified ICF categories in the component "Activities and Participation" and their frequencies are shown in Table 3. Regarding the distribution of the linked activities across the relevant ICF chapters, the majority of the total number of ICF categories related to the ICF chapter "Mobility", in both RA (76.6%) and axSpA (70.1%).None of the activities appeared to be related to the ICF chapters "Learning and applying knowledge", "General tasks or demands" or "Interpersonal interactions and relationships".2) PROMIS PF-10 (13.5-61.9),mean (SD) 33.9 (5.2) 35.8 (4.5) HAQ-DI (0-3), mean (SD) 1.7 (0.5) -BASFI (0-10), mean (SD) -6.1 (1.9) N = 153 Table 4 summarizes the five most frequently identified ICF categories based on the meaningful concepts of all three PSC activities combined and per PSC activity separately.For all PSC activities combined, the five most frequent activities related to "Walking" (RA and axSpA both 2: "Walking long distances" and "Walking on different surfaces"), "Changing basic body position (sitting (RA) and bending" (axSpA)), "Stair climbing" (RA), "Grasping" (RA), "Maintaining a standing position" (axSpA), and "Lifting" (axSpA).
When comparing the frequencies of ICF categories across the three ranked activities, limitations in "Walking" were relatively more frequent in the PSC activities ranked 1, in both RA and axSpA.In RA "Changes in basic body position: sitting", "Grasping", and 'Manipulating" were relatively more frequent in activities ranked 2 or 3, whereas in axSpA "Changing basic body position: sitting", "Changing basic body position: bending" and "Lifting" were relatively more frequent in activities ranked 2 or 3.

Overlap and differences between identified ICF categories and the Brief and Comprehensive ICF Core Sets
An overview of the overlap and differences between the identified ICF categories and the Comprehensive and Brief ICF Core Sets for RA and axSpA within the "Activities and Participation" component is presented in Table 5.The Comprehensive Core Set for RA consists of 32 second-level categories of which 21 (66%) were present in this study.The Brief Core Set for RA consists of six items of which four (67%) were present in this study.Of the 25 identified second-level ICF categories in our study, four categories were not included in the Core Sets for RA: "Stair climbing", "Writing messages", "Moving objects with lower extremities", and "Caring for household objects" with "Stair climbing" being the most common (62/909 total number of ICF categories, 6.8%).
The Comprehensive Core Set for AS comprises of 24 second-level categories of which 14 were reported in this study (58%).The Brief Core Set for AS consists of eight items of which four (50%) were present in this study.Of the 23 identified second-level categories, nine categories were not included in the Core Sets for AS: "Fine hand use", "Writing messages", "Using communication devices and techniques", "Hand and arm use", "Moving around in different locations", "Preparing meals", "Caring for household objects", "Work and employment, other specified and unspecified", and "Stair climbing" with "Fine hand use" being most frequent (62/759 total number of ICF categories, 8.2%).

Discussion
The most frequent limitations in activities as prioritized by people with RA or axSpA and severe functional disability concerned the ICF chapter "Mobility", in particular the categories related to "Walking" and "Changing basic body position".In RA, other frequent limitations were related to "Grasping" and "Stair climbing" whereas in axSpA this concerned "Lifting" and "Maintaining a standing position".There was considerable overlap between the ICF categories identified in the study populations and the corresponding ICF Core Sets, to a greater extent in RA than in axSpA.In our study population, thirteen ICF categories (four in RA and nine in axSpA) were identified that were not included in the Comprehensive Core Sets for RA/AS.Among these categories, "Stair climbing" for RA and "Fine hand use" for axSpA demonstrated a prevalence of more than 5%.
Our findings are partly in line with a previous study employed in four different countries linking rehabilitation goals to the ICF in people with RA patients, where within the "Activities and Participation" component "Walking" and "Self-care" reported most [10].Activities such as "Stair climbing" and "Changing basic body position" were frequently reported in our population but were not found in the latter study.The previous study did not include patients with axSpA, whereas the inclusion of two populations within our study enabled the comparison among people with different rheumatological diagnoses.The ICF category for d530 toiling comprised a total 7 for RA and for axSpA.Four times for both RA and axSpA the ICF category d4531 was assigned and 3 times for both RA and axSpA d530 was assigned Other comparisons are difficult to make, as the population, setting and methods in the present study importantly differed from the previous study [10].In the present study, the included participants had more functional disability as shown by higher HAQ-DI scores, and were treated in primary care and not in a multidisciplinary rehabilitation setting.Moreover, a different method for the assessment of treatment goals was used with elicitation and prioritization of limited activities without explicit goal-setting and only pertained to one component of the ICF (i.e."Activities and Participation").Our study also included people with axSpA, in which knowledge on this topic is more limited.A study in with spondyloarthritis (SpA, including AS) explored the relation between the disease and physical function [36] by means of a survey.They found veterans with SpA had significant more limitations in "Walking", "Transferring", and "Dressing" [36].Although, this study did not use treatment goals, the findings are similar to our study.
The content of the Brief and Comprehensive Core Sets for RA or AS were well reflected in the prioritized activities.Overall, more than half of linked ICF categories as derived from the prioritized limited activities corresponded with the contents of the ICF Core Sets for RA or AS.However, there were exceptions in our study, where certain categories such as "Carrying out daily routine", "Remunerative employment", "Family relationships", and "Acquiring, keeping, and terminating a job" were included in the Brief and Comprehensive Core Sets for AS but were not identified in our study populations.Similarly, for RA, the ICF categories "Carrying out daily routine" and "Remunerative employment" were part of the Brief and Comprehensive Core Sets for RA but were not identified in our study populations.A possible reason for the absence of these categories in our populations could be due to participants being requested to identify three specific limitations in activities that were found important and could be improved with an intervention such as exercise therapy.The discrepancies between the nature of limited activities seen in the present study and the content of the corresponding ICF Core Sets may warrant further exploration.It is first of all possibly related to the specific selection of the study population, being a population of people with severe functional disability.Moreover, the ICF Core Sets were developed more than 10 years ago (RA in 2004 and AS in 2010).Due to the developments of pharmacological interventions in recent years and changing needs of society, limitations in activity might also have evolved over time.Furthermore, for people with axSpA, only the ICF Core Sets for AS were available, whereas the axSpA population encompasses both radiographic and non-radiographic axSpA with patients possibly facing other challenges in daily activities.
This study has a number limitations.First, as our study concerned baseline data of RCTs with specific inclusion and exclusion criteria, it thus concerns a selected population.Moreover, as our RCTs pertained to long standing exercise therapy, patients with a relatively positive attitude towards exercise therapy may have been overrepresented.Either or not related to the previous points, the proportion of females was relatively high in our population, whereas it is known that women are in general more willing to participate in research than men [37].Second, this study concerned the ICF component "Activities and Participation" only and we can, therefore, not make assumptions on limitations perceived regarding the other ICF components.Finally, despite the elaborate descriptions of the methods for linking goals to the ICF as proposed by Cieza et al. [32,33], it was in some cases challenging to link free text of PSC activities to the most appropriate ICF category.For example, PSC activities did not always contain enough specific information to determine the most precise category resulting in the ICF category unspecified.Accurately setting treatment goals can be challenging, because it refers to a future state of functioning achieved through planned treatment actions.A PSC activity that does not contain enough information to determine the most precise ICF category highlights the need for more training of healthcare professionals on goal-setting to further improve the use of PSC activities for individualized tailored treatment of people with RA or axSpA.To overcome some of these problems, some adaptions or additions to the existing linking rules may facilitate unambiguous definition of meaningful concepts and linking to the ICF.
In conclusion, to our knowledge, this is the first study describing the nature of functional limitations as assessed with the PSC for people with RA or axSpA and severe functional disability.It provides insight into the nature and most frequent functional limitations in this subgroup within the "Activities and Participation" component of the ICF, and can, therefore, facilitate healthcare professionals in identifying individual functional limitations in activities and participation and thus improving treatment.The overlap with the Core Sets for RA and AS was relatively high, however, clinicians should be aware that not all RA or AS Core Sets items are prevalent in practice and some prevalent activity limitations prioritized by individual patients are not included in the ICF Core Sets.

Fig. 1
Fig. 1 Standardized linking process of the patient specific complaints (PSC) activities to specific International Classification of Functioning, Disability and Health (ICF) categories: an example PSC goal 1 Looking over the right shoulder during turning right on the bike

Table 1
Baseline characteristics of people with RA or axSpA and severe functional disability participating in a randomized controlled trial on longstanding exercise therapy axSpA axial spondyloarthritis; BASDAI bath ankylosing spondylitis disease activity index; BASFI Bath Ankylosing Spondylitis Functional Index; bDMARDs biologic disease-modifying anti-rheumatic drugs; BMI body mass index; csDMARDs conventional synthetic disease-modifying anti-rheumatic drugs; DAS-28, Disease Activity Score 28; Education level ( Low, primary school or pre-vocational secondary education; Medium, senior general secondary education or pre-university education or secondary vocational education; High, Bachelor or Master at University (of Applied Sciences)); HAQ-DI Health Assessment Questionnaire Disability Index; NSAIDs nonsteroidal anti-inflammatory drugs; PROMIS PF-10 patientreported outcomes measurement information system physical function 10; RA rheumatoid arthritis; tsD-MARDs targeted synthetic disease-modifying anti-rheumatic drugs

Table 2
Results of PSC activities, meaningful concepts and ICF categories in people with RA or axSpA and severe functional disability axSpA axial spondyloarthritis; ICF International Classification of Functioning, Disability and Health; IQR interquartile range; PSC patient-specific complaints instrument; RA rheumatoid arthritis

Table 4
Five most prevalent ICF categories identified in people with RA or axSpA and severe functional disability, in total and by PSC activity

Table 4 (
axSpA axial spondyloarthritis; ICF International Classification of Functioning, Disability and Health; PSC patient specific complaints instrument; RA rheumatoid arthritis a Shared ranking in top-5 due to same reported number