The Arabic version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Arabic language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic and clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the 3 Likert assumptions, floor/ceiling effects, internal consistency, Cronbach’s alpha, interscale correlations, test–retest reliability, and construct validity (convergent and discriminant validity). A total of 100 JIA patients (27.0% systemic JIA, 23.0% oligoarticular, 25.0% RF negative polyarthritis, and 25.0% other categories) and 100 healthy children, were enrolled in one paediatric rheumatology centre. The JAMAR components discriminated well healthy subjects from JIA patients. All JAMAR components revealed satisfactory psychometric performances. In conclusion, the Arabic version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and in clinical research.


Introduction
The aim of the present study was to cross-culturally adapt and validate the Arabic parent, child/adult version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) [1] in patients with juvenile idiopathic arthritis (JIA). The JAMAR assesses the most relevant parent/patient reported outcomes in JIA, including overall well-being, functional status, health-related quality of life (HRQoL), pain, morning stiffness, disease activity/status/course, articular and extra-articular involvement, drug-related side effects/compliance, and satisfaction with illness outcome.
This project was part of a larger multinational study conducted by the Paediatric Rheumatology International Trials Organization (PRINTO) [2] aimed to evaluate the Epidemiology, Outcome and Treatment of Childhood Arthritis (EPOCA) in different geographic areas [3].
We report herein the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Arabic language.

Materials and methods
The methodology employed has been described in detail in the introductory paper of the supplement [4]. In brief, it was a cross-sectional study of JIA children, classified according to the ILAR criteria [5,6] and enrolled from January 2012 to January 2016. Children were recruited after Ethics Committee approval and consent from at least one parent.

The JAMAR
The JAMAR [1] includes the following 15 sections: 1. Assessment of physical function (PF) using 15-items in which the ability of the child to perform each task is scored as follows: 0 = without difficulty, 1 = with some difficulty, 2 = with much difficulty, 3 = unable to do and not applicable if it was not possible to answer the question or the patient was unable to perform the task due to their young age or to reasons other than JIA. The total PF score ranges from 0 to 45, and has three components: PF-lower limbs (PF-LL); PF-hand and wrist (PF-HW) and PF-upper segment (PF-US) each scoring from 0 to 15 [7]. Higher scores indicate higher degree of disability [8][9][10]. 2. Rating of the intensity of the patient's pain on a 21-numbered circle visual analogue scale (VAS) [11]. 3. Assessment of the presence of joint pain or swelling (present/absent for each joint). 4. Assessment of morning stiffness (present/absent). 5. Assessment of extra-articular symptoms (fever and rash) (present/absent). 6. Rating of the level of disease activity on a 21-circle VAS. 7. Rating of disease status at the time of the visit (categorical scale).
8. Rating of disease course from previous visit (categorical scale). 9. Checklist of the medications the patient is taking (list of choices). 10. Checklist of side effects of medications. 11. Report of difficulties with medication administration (list of items). 12. Report of school/university/work problems caused by the disease (list of items). 13. Assessment of HRQoL, through the Physical Health (PhH), and Psychosocial Health (PsH) subscales (5 items each) and a total score. The four-point Likert response, referring to the prior month, are 'never' (score = 0), 'sometimes' (score = 1), 'most of the time' (score = 2) and 'all the time' (score = 3). A 'not assessable' column was included in the parent version of the questionnaire to designate questions that cannot be answered because of developmental immaturity. The total HRQoL score ranges from 0 to 30, with higher scores indicating worse HRQoL. A separate score for PhH and PsH (range 0-15) can be calculated. [12][13][14]. 14. Rating of the patient's overall well-being on a 21-numbered circle VAS. 15. A question about satisfaction with the outcome of the illness (yes/no) [15].The JAMAR is available in three versions, one for parent proxy-report (child's age 2-18), one for child self-report, with the suggested age range of 7-18 years, and one for adults.

Cross-cultural adaptation and validation
The process of cross-cultural adaptation was conducted according to international guidelines with 2-3 forward and backward translations. In those countries for which the translation of JAMAR had been already cross-cultural adapted in a similar language (i.e., Spanish in South American countries), only the probe technique was performed.. Reading comprehension and understanding of the translated questionnaires were tested in a probe sample of ten JIA parents and ten patients. Each participating centre was asked to collect demographic, clinical data, and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents.
The statistical validation phase explored the descriptive statistics and the psychometric issues [16]. In particular, we evaluated the following validity components: the first Likert assumption (mean and standard deviation [SD] equivalence); the second Likert assumption or equal item-scale correlations (Pearson r: all items within a scale should contribute equally to the total score); the third Likert assumption (item internal consistency or linearity for which each item of a scale should be linearly related to the total score, that is, 90% of the items should have Pearson r ≥ 0.4); floor/ceiling effects (frequency of items at lower and higher extremes of the scales, respectively); internal consistency, measured by the Cronbach's alpha, interscale correlation (the correlation between two scales should be lower than their reliability coefficients, as measured by Cronbach's alpha); test-retest reliability or intraclass correlation coefficient (reproducibility of the JAMAR repeated after 1 or 2 weeks); and construct validity in its two components: the convergent or external validity which examines the correlation of the JAMAR subscales with the six JIA core-set variables, with the addition of the parent assessment of disease activity and pain by the Spearman's correlation coefficients (r) [17] and the discriminant validity, which assesses whether the JAMAR discriminates between the different JIA categories and healthy children [18].
Quantitative data were reported as medians with first and third quartiles and categorical data as absolute frequencies and percentages.
The complete Arabic parent and patient versions of the JAMAR are available upon request to PRINTO.

Cross-cultural adaptation
The Arabic JAMAR was fully cross-culturally adapted from the standard English version with three forward and two backward translations.
The concordance rate between the original standard English version of the JAMAR and the two back-translations was 90.2% (111/123 lines) for the parent version and 72.5% (87/120 lines) for the child version.
All 123 lines of the parent version of the JAMAR were understood by at least 80% of the 10 parents tested (median = 100%; range 90-100%). Of the 120 lines in the patient version of the JAMAR, 118 (98%) lines were understood by at least 80% of the children (median = 100%; range 60-100%). Lines 17 and 71 of the child version of the JAMAR were modified considering patients' suggestions.

Demographic and clinical characteristics of the subjects
A total of 100 JIA patients and 100 healthy children (total of 200 subjects) were enrolled at the King Faisal Specialist Hospital and Research Center, Riyadh.
A total of 199/200 (99.5%) subjects had the parent version of the JAMAR completed by a parent (99 from parents of JIA patients and 100 from parents of healthy children). The JAMAR was completed by 143/199 (71.9%) mothers and 56/199 (28.1%) fathers. The child version of the JAMAR was completed by 187/200 (93.5%) children age 5.0 or older. In addition, patients younger than 7 years old, capable to assess their personal condition and able to read and write, were asked to fill in the patient version of the questionnaire.

Discriminant validity
The JAMAR results are presented in Table 1, including the scores [median (first-third quartile)] obtained for the PF, the PhH, the PsH subscales, and total score of the HRQoL scales. The JAMAR components discriminated well between healthy subjects and JIA patients.
In summary, the JAMAR revealed that JIA patients had a greater level of disability and pain, as well as a lower HRQoL than their healthy peers.

Psychometric issues
The main psychometric properties of both parent and child versions of the JAMAR are reported in Table 2. The following "Results" section refers mainly to the parent's version findings, unless otherwise specified.

Descriptive statistics (first Likert assumption)
There were no missing results for all JAMAR items, since data were collected through a web-based system that did not allow skipping answers and input of null values. The response pattern for both PF and HRQoL was positively skewed toward normal functional ability and normal HRQoL. All response choices were used for the different HRQoL items except for items 9 and 10, whereas a reduced number of response choices was used for all the PF items except for items 3 and 4. The mean and SD of the items within a scale were roughly equivalent for the PF and for the HRQoL items (data not shown). The median number of items marked as not applicable was 0% (0-0%) for the PF and 0% (0-2%) for the HRQoL.

Floor and ceiling effect
The median floor effect was 87.9% (75.8-91.9%) for the PF items, 65.7% (61.6-76.8%) for the HRQoL PhH items, and 77.8% (69.7-84.8%) for the HRQoL PsH items. The median ceiling effect was 0% (0-0.0%) for the PF items, 2.0% (2.0-4.0%) for the HRQoL PhH items, and 1.0% Table 1 Descriptive statistics (medians, first-third quartiles or absolute frequencies and %) for the 100 JIA patients Data related to the JAMAR refer to the 99 JIA patients and to the 100 healthy subjects for whom the questionnaire has been completed by the parents JAMAR Juvenile Arthritis Multidimensional Assessment Report; ESR erythrocyte sedimentation rate; MD medical Doctor; VAS visual analogue scale (score 0-10; 0 = no activity, 10 = maximum activity); LOM limitation of motion; ANA anti-nuclear antibodies; PF physical function (total score ranges from 0 to 45); HRQoL health-related quality of life (total score ranges from 0 to 30); PhH physical health (total score ranges from 0 to 15); PsH psychosocial health (total score ranges from 0 to 15) p values refer to the comparison of the different JIA categories or to JIA versus healthy. *p < 0.05, **p < 0.001, # p < 0.0001  No. swollen joints 0 (0-1) No. joints with pain No. joints with LOM Active systemic features

Equal item-scale correlations (second Likert assumption)
Pearson item-scale correlations corrected for overlap were roughly equivalent for items within a scale for 93% of the

Item internal consistency (third Likert assumption)
Pearson item-scale correlations were ≥ 0.4 for 93% of items of the PF (except for PF item 15) and 100% of items of the HRQoL.

Cronbach's alpha internal consistency
Cronbach's alpha was 0.82 for PF-LL, 0.82 for PF-HW, and 0.71 for PF-US. Cronbach's alpha was 0.84 for HRQoL PhH and 0.84 for HRQoL PsH.

Interscale correlation
The Pearson correlation of each item of the PF and the HRQoL with all items included in the remaining scales of the questionnaires was lower than the Cronbach's alpha.

Test-retest reliability
Reliability was assessed in 10 JIA patients, by re-administering both versions (parent and child) of the JAMAR after a median of 0 day (0-0 days). The intraclass correlation coefficients (ICC) for the PF total score showed an almost perfect reproducibility (ICC = 1.0). The ICC for the HRQoL PhH and for the HRQoL PsH scores showed an almost perfect reproducibility (ICC = 1.0, for both).

Convergent validity
The Spearman correlation of the PF total score with the JIA core set of outcome variables ranged from 0.4 to 0.6 (median = 0.6). The PF total score best correlation was observed with the parent assessment of pain (r = 0.7, p < 0.001). For the HRQoL, the median correlation of the PhH with the JIA core set of outcome variables ranged from 0.5 to 0.7 (median = 0.6), whereas that for the PsH ranged from 0.3 to 0.6 (median = 0.4). The PhH showed the best correlation with the parent's assessment of pain (r = 0.8, p < 0.001) and the PsH with the physician global assessment of well-being (r = 0.6, p < 0.001). The median correlations between the pain VAS, the well-being VAS, and the disease activity VAS and the physician-centred, and laboratory measures were 0.5 (0.5-0.6), 0.6 (0.5-0.7), and 0.6 (0.5-0.7), respectively.

Discussion
In this study, the Arabic version of the JAMAR was fully cross-culturally adapted from the original Standard English version with three forward and two backward translations. According to the results of the validation analysis, the Arabic parent and patient versions of the JAMAR possess satisfactory psychometric properties. The disease-specific components of the questionnaire discriminated well between patients with JIA and healthy controls. Psychometric performances were good for all domains of the JAMAR with few exceptions: 1 PF item ("bite a sandwich or an apple") showed a lower item's internal consistency. However, the overall internal consistency was good for all the domains.
In the external validity evaluation, the Spearman's correlations of the PF and HRQoL scores with JIA core-set parameters ranged from moderate to strong.
The results obtained for the parent version of the JAMAR are very similar to those obtained for the child version, which suggests that children are equally reliable proxy reporters of their disease and health status as their parents. The JAMAR is aimed to evaluate the side effects of medications and school attendance, which are other dimensions of daily life than most of the previously used HRQoL tools. This may provide useful information for intervention and follow-up in health care.
In conclusion, the Arabic version of the JAMAR was found to have satisfactory psychometric properties, and it is, thus, a reliable and valid tool for the multidimensional assessment of children with JIA.