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Preparation and characterization of nanofibrous scaffolds containing copper nanoparticles and curcumin for wound healing applications

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Abstract

Advanced therapeutic dressings are the current research interest that achieves rapid and complete wound healing. The healing of skin wounds demonstrates a remarkable cellular function process that is distinct in nature and involves the interaction of various cells, growth factors, and cytokines. In this study, nanofibrous scaffolds were prepared using poly(ε-caprolactone) and polylactic acid as mat scaffolds. Also, copper nanoparticles (CuNPs) and curcumin were added to fabricate a hybrid nanocomposite scaffold using the electrospinning technique. The fabricated scaffolds were analyzed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), tensile analysis, porosity, and water vapor transmission rate. SEM analysis proved the nanostructured fibers have suitable porosity without any beads. The presence of CuNPs in the PCL-Cu nanofibrous mat was confirmed by TEM analysis. The tensile test confirmed an increase and decrease in the elongation ratio by CuNPs and curcumin addition, respectively. The biocompatibility and cell attachment to the nanofibers were proved by MTT and DAPI staining which proved a significantly positive effect of curcumin in the cell growth. The scaffold can hinder both the gram-negative and gram-positive bacteria through direct contact with them. This research study showed that the addition of CuNPs and curcumin in the hybrid nanocomposite scaffold compensates for each other's shortcomings and has the potential to be used in wound healing applications.

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Acknowledgements

Hereby, we extend our gratitude to the stem cell technology research center.

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Authors and Affiliations

  1. Stem Cell Technology Research Center (STRC), Iran University of Medical Sciences (IUMS), Tehran, Iran

    Mahsa Khalili & Elaheh Esmaeili

  2. Department of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran

    Alireza Afrouzan

  3. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Sahar Mehrjou

  4. Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq

    Yasir Q. almajidi

  5. Department of Chemistry, College of Arts and Science, Prince Sattam Bin Abdulaziz University, 11991, Wadi Al-Dawasir, Saudi Arabia

    Ebraheem Abdu Musad Saleh

  6. Department of Epidemiology and Biostatistics, Catholic University of Cuenca, Cuenca, Ecuador

    Andrés Alexis Ramírez-Coronel

  7. Universidad Rafael Belloso, Maracaibo, Venezuela

    Rosario Mireya Romero-Parra

  8. Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia

    Kousalya Prabahar

  9. Department of Pharmacy Practice, Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, 600077, India

    Kousalya Prabahar

  10. Department of Mechatronic, East China University of Science and Technology, Shanghai, China

    Mehdi Radmehr

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  1. Mahsa Khalili
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Contributions

MK analyzed conceptualization, formal analysis, funding acquisition, investigation, methodology, project administration, validation, visualization, and writing—original draft. AA performed methodology, writing—original draft, and investigation. SM developed software and formal analysis. YQA provided data curation and original draft. EAMS prepared data curation. AARC did data curation. RMRP approved data curation. KP conducted data curation. MR revised review & editing. EE carried out conceptualization, project administration, funding acquisition, supervision, resources, formal analysis, validation, and writing.

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Correspondence to Elaheh Esmaeili.

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Khalili, M., Afrouzan, A., Mehrjou, S. et al. Preparation and characterization of nanofibrous scaffolds containing copper nanoparticles and curcumin for wound healing applications. Polym. Bull. (2024). https://doi.org/10.1007/s00289-024-05148-6

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