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Chitosan/calcium phosphate-nanoflakes-based biomaterial: a potential hemostatic wound dressing material

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Abstract

The present study describes the synthesis of the calcium phosphate nanoflakes (CaP-NFs) dispersed chitosan (CCP) hemostatic dressing materials. The surface morphology of the CCP-based hemostatic dressing materials was rough and porous, which aided advantages in controlling blood loss. The positively charged CCP-based hemostatic dressing materials lead to strong blood cell adhesion. The efficiency of the CCP-based hemostatic dressing materials was ascertained by performing different biochemical tests assay. The dressing materials were also tested against both Gram-negative (Escherichia coli (E. coli)) and Gram-positive (Staphylococcus aureus (S. aureus)) bacterial strains. The CCP-based hemostatic dressing materials are highly biocompatible and undergo immediate blood clotting within 15 s of exposure. Moreover, the prepared CCP-based hemostatic dressing materials effectively kill or inhibit the growth of bacteria. Therefore, CCP-based hemostatic dressing materials have the potential ability to control loss of blood and bacterial infection.

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Acknowledgements

The authors are thankful to Dr. Raju Kumar Gupta, Department of Chemical Engineering, Indian Institute of Science and Technology Kanpur, Kanpur, India, for providing research support. Authors also thankful to Dr. Noor Aman, Department of Chemistry, BS Abdur Rahman Institute of Science and Technology, Chennai, India, for providing research support.

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The authors did not receive any financial support from any organization for the submitted work.

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Authors and Affiliations

  1. School of Life Science, BS Abdur Rahman Institute of Science and Technology, Chennai, 600048, India

    A. Mohamed Akram & Mohammad Ashfaq

  2. Centre for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, India

    Rishabh Anand Omar

  3. University Centre for Research & Development (UCRD), Chandigarh University, NH-95, Ludhiana - Chandigarh State Hwy, Gharuan, Mohali, Punjab, 140413, India

    Mohammad Ashfaq

  4. Department of Biotechnology, Chandigarh University, NH-95, Ludhiana - Chandigarh State Hwy, Gahruan, Mohali, Punjab, 140413, India

    Mohammad Ashfaq

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  1. A. Mohamed Akram
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MAM perform experiments, RAO perform some experiments, and MA design and writing manuscript.

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Correspondence to Mohammad Ashfaq.

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Akram, A.M., Omar, R.A. & Ashfaq, M. Chitosan/calcium phosphate-nanoflakes-based biomaterial: a potential hemostatic wound dressing material. Polym. Bull. 80, 5071–5086 (2023). https://doi.org/10.1007/s00289-022-04300-4

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  • DOI: https://doi.org/10.1007/s00289-022-04300-4

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