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Preparation and pH/temperature dual drug release behavior of polyamino acid nanomicelles

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Abstract

Poly(lysine-phenylalanine-tyrosine) block copolymers were synthesized by ring-opening polymerization of amino anhydride, and the structure was characterized by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectrum. The amphiphilic copolymers could be self-assembled with model-drug Doxorubicin to form spherical nanomicelles in the mixed solution of DMSO and water. The particle size distribution and morphology were characterized investigated by dynamic light scattering and transmission electron microscope, respectively. Drug release experiments in vitro showed that the nanomicelles were pH/temperature dual responsiveness. The cumulative release rate of the drug under acidic conditions could get to more than 82% at 37 °C.

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Acknowledgements

This work was supported by the Fundamental Research Funds for the Central Universities (N2105005, N2005004), National Nature Science Foundation of China (31560268, 21861040), Fujian Natural Science Foundation (2019J0106), and Scientific Research Fund project of Ningde Normal University (2020Z02, 2020ZX502, 2019ZX405, 2018Y06, 2018T02).

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Authors and Affiliations

  1. Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang, 110819, People’s Republic of China

    Zhuang Hu, Zhihao Guo, Siyu Han, Zhangpei Chen & Jianshe Hu

  2. Fujian Province University Engineering Research Center of Mindong She Medicine, Medical College, Ningde Normal University, Ningde, 352100, Fujian, People’s Republic of China

    Jiwei Wang

  3. Key Laboratory of Toxicology, Medical College, Ningde Normal University, Ningde, 352100, People’s Republic of China

    Aikebaier Reheman

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  1. Zhuang Hu
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  2. Zhihao Guo
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  3. Siyu Han
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  4. Zhangpei Chen
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  5. Jiwei Wang
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  6. Jianshe Hu
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Correspondence to Jianshe Hu or Aikebaier Reheman.

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Hu, Z., Guo, Z., Han, S. et al. Preparation and pH/temperature dual drug release behavior of polyamino acid nanomicelles. Polym. Bull. 79, 4685–4699 (2022). https://doi.org/10.1007/s00289-021-03735-5

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  • DOI: https://doi.org/10.1007/s00289-021-03735-5

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