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Designing gelatin-based swellable hydrogels system for controlled delivery of salbutamol sulphate: characterization and toxicity evaluation

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Abstract

Purpose of the current research work was to synthesize gelatin based hydrogels for the controlled release of salbutamol sulphate. Free radical polymerization technique was used for the synthesis of hydrogels. Gelatin was cross-linked chemically with monomer methacrylic acid using methylene bisacrylamide as cross-linker while ammonium persulphate and sodium metabisulphite were used as initiators. All the formulations were evaluated through Fourier transform infrared spectroscopy, differential scanning calorimetry, thermo gravimetric analysis and scanning electron microscopy. Swelling properties of formulated hydrogels were also evaluated in both pH 7.4 and 1.2. For drug release study, USP peddle method was used and release study was carried out in both pH 7.4 and 1.2. Fourier transform infrared spectroscopy confirmed that drug salbutamol sulphate is compatible with the formulated system. Moreover, thermal stability was also confirmed by TG/DSC studies providing the fact that thermal stability of the formulated hydrogels is high as compared to individual content. Sol–gel fraction confirmed that gel content increased as the concentrations of the polymer, monomer and cross-inker were increased. All formulations showed profound gel fraction. Similarly, pH dependent swelling was observed, experiencing higher swelling at higher pH as compared to lower pH. Toxicity study was also conducted which endorsed the safety of the hydrogels as no toxic effect was observed on vital organs.

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Acknowledgements

The authors are thankful for the contribution of the Islamia University of Bahawalpur Pakistan for providing the finances and facilities for performing studies.

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan

    Naila Rafique, Mahmood Ahmad, Syed Faisal Badshah & Kifayat Ullah Khan

  2. College of Pharmacy, University of Sargodha, University Road Sargodha City, Punjab, Pakistan

    Muhammad Usman Minhas

  3. Department of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan

    Nadia Shamshad Malik

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  1. Naila Rafique
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  2. Mahmood Ahmad
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  3. Muhammad Usman Minhas
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  5. Nadia Shamshad Malik
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Correspondence to Mahmood Ahmad.

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Rafique, N., Ahmad, M., Minhas, M.U. et al. Designing gelatin-based swellable hydrogels system for controlled delivery of salbutamol sulphate: characterization and toxicity evaluation. Polym. Bull. 79, 4535–4561 (2022). https://doi.org/10.1007/s00289-021-03629-6

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