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Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: a Double-Blind Randomized Controlled Splitting Face Study

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  • Non-Surgical Aesthetic
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Abstract

Background

As the demand for non-invasive esthetic procedures to maintain a youthful appearance increases, there has been growing interest in the use of autologous platelet-rich plasma (PRP) and platelet-poor plasma (PPP) for the treatment of facial aging. However, there are few studies directly comparing the efficacy of PRP and PPP for facial rejuvenation.

Objectives

This study aimed to compare the efficacy of PRP and PPP for facial rejuvenation.

Methods

This single-center, double-blind, randomized controlled trial was conducted from January 1, 2022, to July 31, 2022, and included ten participants who completed the follow-up. The participants were randomly assigned to receive 2.5-mL injections of PRP and PPP on different sides of the face in three sessions with 1-month intervals. The outcome was primarily determined by blinded photographic assessments and secondly by scores of the VISIA® system during the follow-up.

Results

Both PRP and PPP treatments resulted in significant improvement in the Global Aesthetic Improvement Scales and Modified Fitzpatrick Wrinkle Scale for periocular Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation wrinkles, with no significant difference between the two groups. However, no improvement was observed in the Wrinkle Severity Rating Scales for nasolabial folds in either the PRP- or PPP-treated groups. Furthermore, no severe adverse events were reported.

Conclusions

Both PRP and PPP are effective in treating facial photoaging. PRP exhibited slightly superior efficacy in enhancing overall skin condition, while PPP was slightly more effective in improving shallow wrinkles. This study provides valuable evidence for the use of PRP and PPP in facial rejuvenation procedures.

Level of Evidence I

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Acknowledgement

The authors declare that they have no conflict of interest. Ya-Wen Tsai, MD and Chun-Yu Cheng contributed equally.

Funding

This study was funded by CMRPG5K0121, CGMH.

Author information

Author notes

  1. Ya-Wen Tsai and Chun-Yu Cheng have contributed equally.

Authors and Affiliations

  1. Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan

    Ya-Wen Tsai, Chun-Yu Cheng, Sindy Hu, Shyue-Luen Chang & Yau-Li Huang

  2. Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan, Taiwan

    Chun-Yu Cheng, Sindy Hu, Shyue-Luen Chang & Yau-Li Huang

  3. Center of Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Chun-Yu Cheng

  4. Department of Dermatology, Vein Clinic, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Sindy Hu, Shyue-Luen Chang & Yau-Li Huang

  5. Chang Gung University College of Medicine, Taoyuan, Taiwan

    Sindy Hu, Shyue-Luen Chang & Yau-Li Huang

  6. Charming Institute of Esthetic and Regenerative Surgery (CIARS), Kaohsiung City, Taiwan

    Tsai-Ming Lin

  7. Department of Plastic Surgery, Kaohsiung Medical University, Kaohsiung city, Taiwan

    Tsai-Ming Lin

Authors
  1. Ya-Wen Tsai
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  2. Chun-Yu Cheng
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  3. Sindy Hu
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  4. Shyue-Luen Chang
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  5. Tsai-Ming Lin
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  6. Yau-Li Huang
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Corresponding author

Correspondence to Yau-Li Huang.

Ethics declarations

Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards (Institutional Review Board: 27 Chang Gung Memorial Hospital, Taipei, Taiwan; IRB No. 2003120051).

Trial Registration

NCT05096650 [ClinicalTrials.gov].

Informed Consent

Patients signed informed consent regarding participating the study and publishing their data and photographs.

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Tsai, YW., Cheng, CY., Hu, S. et al. Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: a Double-Blind Randomized Controlled Splitting Face Study. Aesth Plast Surg 48, 2162–2170 (2024). https://doi.org/10.1007/s00266-023-03822-0

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  • DOI: https://doi.org/10.1007/s00266-023-03822-0

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