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Evaluating the Efficacy of Liposomal Bupivacaine in Postoperative Pain Management for Rhinoplasty: A Retrospective Study

  • Original Articles
  • Rhinoplasty
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Abstract

Background

Rhinoplasty, a leading cosmetic surgical procedure, often involves the use of opioids for postoperative pain management. This raises concerns due to potential opioid side effects and overprescription. Liposomal bupivacaine offers a promising alternative, but its efficacy in rhinoplasty remains under-investigated. This study assesses the impact of liposomal bupivacaine on postoperative pain and opioid consumption following rhinoplasty.

Methods

A retrospective study was conducted on patients undergoing rhinoplasty between January 2014 and September 2020. Postoperative pain scores were assessed at intervals up to 16 h, and opioid consumption was monitored. Patients were stratified into two groups: those receiving postoperative liposomal bupivacaine (Group 1) and those who did not (Group 2).

Results

No significant disparities in demographics or surgical specifics were identified between groups. Group 1 consistently reported lower pain scores, notably at 30 min (1.4 vs. 3.7, p = 0.0006) and 2 h (2.2 vs. 3.38, p = 0.0417). Cumulatively, Group 1’s average pain score was 2.4, significantly lower than Group 2’s 3.4 (p = 0.0023). Group 1 also demonstrated reduced opioid consumption, with oxycodone and oral morphine equivalent (OME) intake being notably lower (p = 0.005 and p = 0.0428, respectively).

Conclusion

Liposomal bupivacaine presents as an efficacious alternative for post-rhinoplasty pain management, reducing both perceived pain and opioid consumption. While promising, the findings necessitate validation through larger, prospective studies considering the inherent limitations of this preliminary investigation.

  • This study evaluates the efficacy of liposomal bupivacaine as a pain management strategy in postoperative care for rhinoplasty and septorhinoplasty procedures, with the potential to reduce reliance on opioids.

  • The findings indicate that patients receiving liposomal bupivacaine experienced significantly lower pain scores postoperatively and less overall opioid consumption, thereby enhancing patient comfort and safety.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Acknowledgements

The authors declare that they have no conflict of interest to disclose. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. For this type of study formal consent is not required.

Funding

The authors declare that they have no commercial interests in the subject of this study and have received no financial or material support relevant to this research.

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Authors and Affiliations

  1. Division of Plastic Surgery, Mayo Clinic, Rochester, MN, USA

    Khaled O. Alameddine, Bradley A. Richards, Krishna Vyas, Arif Chaudhry, Elena Millesi & Uldis Bite

  2. Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN, USA

    Grant S. Hamilton

Authors
  1. Khaled O. Alameddine
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  2. Bradley A. Richards
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  3. Krishna Vyas
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  5. Elena Millesi
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  7. Uldis Bite
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Correspondence to Khaled O. Alameddine.

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Alameddine, K.O., Richards, B.A., Vyas, K. et al. Evaluating the Efficacy of Liposomal Bupivacaine in Postoperative Pain Management for Rhinoplasty: A Retrospective Study. Aesth Plast Surg 48, 1722–1727 (2024). https://doi.org/10.1007/s00266-023-03656-w

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  • DOI: https://doi.org/10.1007/s00266-023-03656-w

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