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Dendrobium officinale Polysaccharide (DOP) Promotes Hair Regrowth in Testosterone-Induced Bald Mice

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Abstract

Background

Androgenetic alopecia can affect up to 70% of males and 40% of females; however, certain therapeutic medications offer partial and transitory improvement but with major side effects. Dendrobium officinale polysaccharide (DOP) has been reported to improve androgen-related hair loss in mice, but the molecular mechanism remains unclear.

Objectives

To explore the effects of DOP on androgenetic alopecia.

Methods

In this study, testosterone was subcutaneously administered to shave dorsa skin of mice to establish androgenetic alopecia; the effects of DOP in androgenetic alopecia were explored by DOP administration.

Results

Testosterone treatment extended the time of skin growing dark and hair growing, decreased the mean numbers of follicles in skin tissues, decreased β-catenin and cyclin D1 levels, and elevated testosterone, DHT (dihydrotestosterone), and 5α-reductase levels. In contrast, DOP administration shortened skin growing dark and hair growing times, promoted follicle cell proliferation, increased follicle numbers, increased β-catenin and cyclin D1 levels, and decreased testosterone, DHT, and 5α-reductase levels.

Conclusion

DOP application significantly improved testosterone-induced hair follicle miniaturization and hair loss, possibly through affecting the Wnt signaling and hair follicle stem cell functions.

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Data Availability

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Acknowledgment

This study was supported by Hunan Province High-tech Industry Science and Technology Innovation Leading Program (Science and Technology Research) [Grant No. 2020SK2023], the Natural Science Foundation of Hunan Province, China [Grant Nos. 2021JJ40414, 2020JJ5431 and 2021JJ40412], the Scientific Research Project of Hunan Provincial Department of Education [Grant No. 20A372], the First-level Discipline Open Fund Project of Nursing in Hunan University of Chinese Medicine (2020HLX02), the National Natural Science Foundation of China (82004381), the Key Project of the First-class Open Fund of Traditional Chinese medicine (2022ZYX05) and Traditional Chinese Medicine Research Program Youth Project of Hunan Province (2021187).

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Authors and Affiliations

  1. Department of Dermatology, The Second Hospital of Hunan University of Chinese Medicine, The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, 410005, Hunan, China

    Yujin Zhang, Ying Li, Haizhen Wang, Youhua Peng, Meijunzi Luo, Pan Huang, Bijun Zeng & Zhibo Yang

  2. The Graduate School, Hunan University of Chinese Medicine, Changsha, 410005, Hunan, China

    Qing Tang & Jie Gao

  3. Department of Dermatology, The Ninth Hospital of Changsha, Changsha, 410004, Hunan, China

    Jie Gao

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  1. Yujin Zhang
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Zhang, Y., Li, Y., Tang, Q. et al. Dendrobium officinale Polysaccharide (DOP) Promotes Hair Regrowth in Testosterone-Induced Bald Mice. Aesth Plast Surg 47, 833–841 (2023). https://doi.org/10.1007/s00266-022-03144-7

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  • DOI: https://doi.org/10.1007/s00266-022-03144-7

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