Anterior knee pain after total knee arthroplasty: a narrative review

Anterior knee pain is one of the most common causes of persistent problems after implantation of a total knee replacement. It can occur in patients with or without patellar resurfacing. As a result of the surgical procedure itself many changes can occur which may affect the delicate interplay of the joint partners in the patello-femoral joint. Functional causes of anterior knee pain can be distinguished from mechanical causes. The functional causes concern disorders of inter- and intramuscular coordination, which can be attributed to preoperative osteoarthritis. Research about anterior knee pain has shown that not only the thigh muscles but also the hip and trunk stabilising muscles may be responsible for the development of a dynamic valgus malalignment. Dynamic valgus may be a causative factor for patellar maltracking. The mechanical causes of patello-femoral problems after knee replacement can be distinguished according to whether they increase instability in the joint, increase joint pressure or whether they affect the muscular lever arms. These causes include offset errors, oversizing, rotational errors of femoral or tibial component, instability, maltracking and chondrolysis, patella baja and aseptic loosening. In these cases, reoperation or revision is often necessary.


Introduction
According to the literature, the satisfaction rates after total knee arthroplasty (TKA) vary between 75 and 89 % [2,28,30,55,61,79]. Within the first five years after primary implantation, the revision rate is 2.8 %, and the rate of reoperations without exchange of components is 4.3 % [81].
Anterior knee pain is one of the most common causes of persistent problems after implantation of a total knee replacement. It can occur with or without patellar resurfacing. Sensi et al. [69] reported an incidence of 8 % for anterior knee pain after TKA. The intensity of pain is mostly mild to moderate [69]. In this study, no revision had to be performed in any case. Nevertheless, after joint infection, patello-femoral problems are one of the most common reasons for reoperation or revision after TKA [8,20,21,48,70,71,75].
The indication for secondary patellar resurfacing for anterior knee pain should be arrived at with care, because the success rate is stated to vary between only 50 and 60 % [15,17,24,50,51]. One reason for this observation could be that many other causes of anterior knee pain are responsible besides progression of arthritis and retropatellar cartilage damage.
The causes of anterior knee pain are multifactorial and can be divided into functional (muscle imbalances, dynamic valgus) and mechanical (incorrect positioning of prosthetic components, patellar fractures, aseptic loosening, etc.) problems. Many of these problems can be avoided at the primary TKA. However, in every painful TKA an infection should always be ruled out.
The aim of this review article is to summarise knowledge from the literature to provide an overview of this complex subject and present a guide for rational diagnosis.
Can patellar resurfacing prevent anterior knee pain?
The necessity for patellar resurfacing in TKA is discussed extensively in the literature [12,22,58]. Fu et al. [22] conducted a meta-analysis of the efficacy of patellar resurfacing in TKA; ten studies with 1,003 TKA were included. In this study there was no difference in the incidence of anterior knee pain. The risk for reoperation, however, was lower in the resurfacing group than in the group without resurfacing. Similar results were published by He et al. [29]. This meta-analysis included 16 studies with more than 3,000 knee joints. There was no difference between the two groups in terms of anterior knee pain rate, knee pain score, Knee Society knee score and function. The incidence of reoperations in patients without resurfacing was lower than in patients with resurfacing [29]. When only high-quality studies were analysed, there was no difference in reoperation rates between the two groups. From these results, no clear recommendation can currently be made regarding the need for patellar resurfacing regarding the prevention of anterior knee pain.
We see an indication of advanced destructive osteoarthritic changes of the patella with clinical symptoms of anterior knee pain. Otherwise, a "trimming" is carried out with circular synovectomy and denervation. Both methods may be associated with complications which may be a cause of anterior knee pain. A problem of TKA without patellar resurfacing is chondrolysis (see the "Chondrolysis or progression of patella osteoarthritis" section). Problems after patellar resurfacing are aseptic loosening, lateral facet syndrome, fractures or "overstuffing" [25]. An over conservative resection can cause overstuffing with increased tension on the retinacula [25]. Too much resection increases the risk of fracture of the patella. An uncovered lateral facet due to a small or medialised implant may lead to a lateral facet syndrome.
The indication for secondary patellar resurfacing with anterior knee pain should be made with caution, because of reported success rates of 50-60 % [15,17,24,50,51]. One reason for this observation may be that the cartilage damage of the patella may not be the cause of anterior knee pain. Bhattee et al. [6] have demonstrated that many patients with a poor result after secondary patellar resurfacing have an internal rotational error of the femoral component of more than 3°. Another cause of poor results after secondary patellar resurfacing may be an unrecognised extra-articular pathology [1].
"Natural" course of pain after uncomplicated TKR If factors are analysed which may be responsible for anterior knee pain after TKA, it is important to know the natural course of pain after uncomplicated TKA [37]. Brander et al. [11] and Forsythe et al. [23] have studied the intensity of pain after implantation of a simple total knee replacement during the first post-operative year with a visual analogue scale. In the Brander et al. study, the preoperative pain level dropped from an average of 52 points to 25 points after three months. After one year, the pain level was still at an average of 17 points. This was still 32 % of the initial value. Similar findings were stated by Forsythe et al. [23]. In the Forsythe et al. study pain intensity decreased on the visual analogue scale from 68 points to 33 after three months, to 27 after one year and to 22 after two years.
These results are relevant to the development of anterior knee pain after TKA because these series may also include patients with anterior knee pain. The predictors for pain may be divided into modifiable factors and non-modifiable factors. The non-modifiable predictors include the female gender, severe preoperative pain, low pain threshold and young age [10,37]. The modifiable predictors include anxiety, depression and problems of pain processing [23]. According to Forsythe et al. [23], patients with increased post-operative pain had a high value on the pain catastrophising scale (PCS). Brander et al. [11] found a correlation to a high anxiety score and depression score. Another predictor for pain after TKR is the preoperative arthritis severity [67].
One problem is certainly in the fulfillment of the preoperative expectations (Fig. 1). Unfulfilled preoperative expectations regarding pain relief within the first post-operative months [11,23,39] may be a cause of fear and uncertainty, factors that may affect the processing of pain. False expectations can be present in particular with regard to pain during certain activities (such as sports). Thus, Bonnin et al. [10] have shown that the incidence of pain in sports such as tennis or golf is generally higher than expected. False expectations may Satisfaction after TKA  Fig. 1 The vicious cycle if expectations after TKA are not fulfilled be a reason for lack of satisfaction after implantation of a total knee replacement.
These findings should be considered when a patient is preoperatively informed about TKA. These facts are also relevant in the diagnosis of anterior knee pain, especially with regard to the indication for revision.

Neurophysiological origin of pain in the patellofemoral joint
The exact mechanism of how and where anterior knee pain develops is unclear. Different causes may be considered [59]. Today, it is well accepted that one main source for pain sensation are the insertions of the extensor apparatus [18,19,[63][64][65]. Sanchis-Alfonso et al. [63,64] demonstrated that patients with anterior knee pain had an increased density of nociceptors in the lateral retinaculum. It is likely that disorders of the patellofemoral mechanics lead to local overload of these structures [65]. These mechanical disorders include patellofemoral instability, lateral patellar maltracking or the increased pressure by the extensor mechanism in the sagittal plane. Various causes may be responsible for these three disorders including incorrect positions of the components of the prosthesis, valgus malalignment of the lower extremity and instabilities. Valgus malalignment can be caused by the position of the components or by muscular insufficiencies and imbalances (dynamic valgus) [52,59].
Local peripatellar synovitis, inflammatory changes in the Hoffa fat pad or osseous oedema can also be considered as causes of anterior knee pain in TKA patients. Van Jonbergen et al. [75] have demonstrated in a systematic review that a peripatellar synovectomy and resection of Hoffa's fat pad have positive effects on pain after TKA.

Functional causes of anterior knee pain after TKA
Most patellofemoral complaints are mild to moderate and do not require any revision [69]. Many of these problems have no structural but a functional cause and may be related to preoperative osteoarthritis.
It is well known that a preoperative weakness of the quadriceps muscle may persist after TKA. This weakness has significant influence on the movement pattern of the knee [34,[45][46][47]. It is also known that imbalance of the quadriceps with weakness of the vastus medialis and increased activation of the vastus lateralis muscle can cause a lateral maltracking of the patella [13,33]. The preoperative quadriceps weakness caused by osteoarthritis may further deteriorate due to the implantation of a total knee replacement (approaching morbidity) and it may take more than two years until the power of the contralateral limb is reached [66].
Patients with osteoarthritis of the knee often present with additional osteoarthritis of the hip [5]. The weakness of the hip abductors and external rotators can lead to dynamic valgus (Fig. 2) [52,59]. If the functional disorder of the hip abductors is caused by osteoarthritis, osteoarthritis of the hip should be treated. Sled et al. [73], however, have shown that patients with knee osteoarthritis profit from training the hip abductors.
Dynamic valgus affects the femoropatellar joint because it leads to lateral patellar maltracking [41,59]. Dynamic valgus or functional malalignment can be clinically detected with the single leg squat [16].
Many patients after TKA present with a "quadriceps avoidance gait" [36]. This leads to a compensatory increased forward inclination of the trunk [36]. Some patients also have comorbidities of the lumbar spine. A decreased lumbar lordosis leads to increased pelvic tilt and compensatory to increased knee flexion with increased stress on the femoropatellar joint [74]. Tsuji et al. [74] named this condition the knee spine syndrome. Degenerative co-morbidities of the lumbar spine and hip are not uncommon in patients with osteoarthritis. Figure 3 summarises the functional causes of anterior knee pain.

Mechanical causes of anterior knee pain
The mechanical causes of patello-femoral problems after knee replacement can be distinguished according to whether they increase instability in the joint, lead to changes in the transmission of the joint pressure or whether they affect the muscular lever arms. These factors are patello-femoral instability, prosthesis design, patella baja, chondrolysis, offset error of the femoral component rotational error, tibiofemoral instability, avascular necrosis and synovial hyperplasia. All of these causes can lead to pain and functional deficits of patients with anterior knee pain after TKA.

Patello-femoral instability and maltracking
Patello-femoral instability is a common cause of postoperative pain and functional limitations in the joint, which may lead to revision surgery [43]. The reported revision rates for patello-femoral instability after TKA are about 1 % [59,66]. To be precise, when talking about patellar instability after TKA most authors mean maltracking rather than recurrent dislocations [60,68] (Fig. 4). A dislocation after TKA is considered to be a very rare event.
The causes of maltracking can be either insufficient soft tissue balancing or component positioning (patella, femoral rotation, valgus malalignment) [49]. However, the design of the femoral component or the patella may also influence the stability of the patella [70]. It has been shown that the depth of the trochlea is proportional to the stability of the patella and the transmitted forces in the patellofemoral joint [80]. An asymmetrical femoral bearing with lateral elevation leads to a more stable experimental patellar tracking as a flat slide bearing, particularly for more than 45°of flexion [80], but also a preoperatively increased tibial tubercle-trochlear groove (TTTG) distance or patella alta can cause instabilities.
Patello-femoral instability or maltracking is usually diagnosed by conventional X-ray (Merchant view) which can demonstrate patella lateralisation, tilting of the patella or a lateral osteophyte (Fig. 4). It is important to note that a lateral osteophyte is able to fix a maltracking of the patella.

Influence of prosthetic designs
The prosthetic design can also play a role in the development of patellofemoral problems, but not only the design of the patello-femoral joint has an impact on the development of anterior knee problems but it has also been shown that femoral  components with a posterior centre of rotation have a favourable influence on anterior knee pain [75]. The degree of coupling may also have an influence on the pressure in the transmission patello-femoral joint. Becher et al. [9] have shown that a posterior stabilised (PS) prosthesis design leads to lower patellofemoral joint pressures than a cruciate-retaining (CR) design. This mechanism should be considered when the patient presents with posterior instability and anterior knee pain after TKA. In a recent meta-analysis, however, no difference was found with regard to postoperative pain between CR prostheses and PS designs [35].

Patella baja
Patella baja (Fig. 5) can also lead to anterior knee pain after TKA [14]. The incidence of patella baja after TKA or unicompartmental arthroplasty is low [3,72]. Sharma et al. [72] studied 135 consecutive patients after TKA with respect to the patellar height. In this study, only one patient developed a post-operative patella baja by definition (Insall-Salvati ratio of less than 0.8). Five patients had a considerable decrease of the Insall-Salvati ratio by 10 %. Risk factors for the development of patella baja after unicompartmental knee arthroplasty are age over 65, male gender and the implementation of a special rehabilitation programme [3]. Patella baja after TKA may be acquired or congenital [14]. Post-operative patella baja may be caused by scarring or contracture of the patellar tendon above the tibial tuberosity. It has been argued that patella eversion can contribute to the development of patella baja. A pseudo-patella baja may arise from an elevated joint line. That means that the patella is in its normal position in relation to the trochlea, but the distance between the patella and the tibia is reduced. A pseudo-patella baja may be the result of a femoral or tibial over-resection with a high inlay. Patella baja can be a problem for revision procedures because in these cases an osteotomy of the tibial tuberosity is often required to expose the joint [14].

Chondrolysis or progression of patella osteoarthritis
In TKA without patellar resurfacing a progression of chondrolysis can lead to patellofemoral pain [70]. The chondrolysis may be the continuation of the osteoarthritic process, but can also be associated with mechanical factors that are attributable to the knee prosthesis implantation (e.g. malrotation of the components).

Offset errors of the femoral component
The anterior offset of the femoral component has a major impact on the mechanics of the patellofemoral joint. An anterior overhang can be caused by selection of a femoral component that is too large [31] or an overly minimal anterior resection (overstuffing). This can lead to increased pressure of the patella and its surrounding structures [69].
However, an increased anterior resection ("undercutting", "notching") can also lead to patellofemoral problems. In this case, the passive quadriceps insufficiency may be a cause of anterior knee pain. Increased posterior offset can also lead to flexion deficit which might also influence the contact pressure in the femoropatellar joint.

Rotational error of the femoral or tibial component
Various studies have shown that an internally rotated femoral or tibial component can cause an increased lateral tilt angle and a lateralisation of the patella [4,6,7,8,32]. Some authors see incorrect rotation of the femoral component as the most common cause of patellar complications after TKA [4,6]. Even an internal rotation of the femoral component of 3-7°c an lead to chronic problems [4,8,32,62,76]. Bhattee et al. [6] have demonstrated that poor results after a secondary patellar resurfacing are often due to rotational error of the femoral component.
An internal rotational error of the tibial component can also lead to patello-femoral problems [54]. In the series of Nicoll and Rowley [54] more than half of the 38 patients with a fixed bearing had an internal rotational error of femoral and tibial components. In contrast to the internal rotation of the tibial component external rotational errors were well tolerated. Based on these findings, a rotary computed tomography (CT) scan should be obtained in patients with anterior knee pain when no other causes are evaluable.

Tibio-femoral instability
As stated above, a posterior tibio-femoral instability, manifested especially in flexion, can affect the patello-femoral joint because the joint contact pressure is increased due to the posterior subluxation (Fig. 6). Causes of flexion instability are an increased tibial slope or iatrogenic or traumatic injury to the posterior soft tissue stabilisers (posterior cruciate ligament, posteromedial and posterolateral corner joint) [57].

Avascular necrosis
Localised pain over the patella under load may indicate avascular necrosis or a transient ischaemia [44,70,78]. The incidence of symptomatic ischaemic necrosis is low. However, up to 10 % of patients after TKA have a pathological femoral radionuclide uptake in the patella during the post-operative period [66]. According to Gelfer et al. [26] the incidence of ischaemic episodes in patients without lateral release is 19.5 %. In patients in whom lateral release was necessary, the incidence is probably even higher [44]. However, intraosseous blood flow does not correlate well with post-operative anterior knee pain [33].

Patellar fracture
Patellar fracture is a rather rare complication after TKA with a prevalence of 0.68 % [56]. When the extensor mechanism is intact and the patellar implant is stable fractures can be treated conservatively (type I fractures) (Fig. 7). An insufficiency of the extensor mechanism usually requires a surgical procedure (type II fracture). A fracture that is associated with a loosened resurfacing also requires a surgical procedure (type III fracture).

Patellar clunk
"Patellar clunk" is a soft tissue impingement in the intercondylar notch. The cause is a fibrous knot above the patella which impinges in flexion on the roof of the intercondylar notch [18,38,42]. The incidence of this phenomenon was more common in older prosthetic models. Today, it is only rarely observed.

Synovial hyperplasia
Synovial hyperplasia can also lead to impingement in the patello-femoral joint [18] (Fig. 8). Synovial hyperplasia may be a result of a persistent post-operative irritation. Nevertheless, it is important to exclude infections or metal hypersensitivity [40,41].

Treatment of anterior knee pain after TKA
Therapy of anterior knee pain after TKA depends on the causes, pain intensity and functional impairment. One can distinguish between functional causes and mechanical causes. For functional causes non-operative treatment is the treatment of choice. For mechanical causes surgical treatment may be indicated. Therefore, mechanical causes should always be excluded before therapy planning. Figure 9 shows an algorithm for the diagnostics to exclude mechanical causes of anterior knee pain after TKA.

Therapy for functional causes
When anterior knee pain is related to functional problems, exercise is the treatment of choice (Fig. 10) [27]. A systematic review has shown that physical therapy in patients with anterior knee pain should address not only the quadriceps, but also hip and trunk muscles to correct the dynamic valgus or functional malalignment [26]. Nakagawa et al. [53] reported that with a combination of quadriceps, hip and trunk stabilisation training a significantly better effect can be achieved than with quadriceps training alone.
There is also evidence that the functional maltracking of the patella can be corrected temporarily with tape or with knee braces which apply a medially directed force on the patella [77]. It has been shown that tape or brace application has a positive effect on anterior knee pain. Tape or brace treatment should support the correction of dynamic valgus by exercise. A synergistic effect has been reported for the combination of exercise and tape [27].

Therapy for mechanical causes
If there are mechanical problems, surgical treatment may be indicated. However, due to the natural course of pain [11,23] the indication for surgery should be made with caution within the first post-operative year. Many patients with mechanical causes of anterior knee pain may also have additional functional problems. Therefore, especially in patients with only mild pain or functional impairment, a conservative therapy trial may be indicated.
We distinguish between revision surgery with exchange or replacement of components of the prosthesis, secondary patellar resurfacing and non-revision reoperations (arthrolysis, synovectomy, lateral release).

Revision
Revision surgery should be considered in patients with incorrectly positioned components (offset and rotational errors), instabilities or aseptic loosening of a patellar resurfacing. Bone loss in cases with offset or rotation corrections can be compensated for with a metal spacer. Therefore, modular revision implants should always be available. In cases with tibio-femoral instability revision with implantation of a model with a higher degree of coupling may be necessary (e.g. change in posterior instability of CR on PS).

Secondary patellar resurfacing
In cases with retropatellar chondrolysis or progressive osteoarthritis the indication for secondary resurfacing should be made cautiously, since in the literature success rates of 66 % are given [12,15,22,29,58].  If the patella plug is incorrectly positioned a revision with a new resurfacing should be considered. In cases with an overstuffed patella the patella plug should be changed and additional bone should be resected. In a lateral facet syndrome, a change of the patella plug or secondary patellar resurfacing should be considered.

Non-revision reoperations
For non-revision surgery arthroscopy plays an important role. In cases of a "maltracking" with lateralisation and increased "tilt" angle an arthroscopic lateral release with peripatellar synovectomy should be considered. Synovectomy and localized arthrolysis may also be a treatment option for cases with peripatellar adhesion or for patellar clunk syndrome. Even lateral patellar osteophytes can be resected arthroscopically. Arthroscopy may also play a role in the diagnostics of lowgrade infections after TKA (history of recurrent swelling). The microbiological and histological analyses of multiple biopsies have a higher sensitivity and specificity than aspiration. One should keep in mind that each case of anterior knee pain can be triggered by an infection.
We do not recommend reconstruction of the medial patellofemoral ligament (MPFL) in patients with patellar instability after TKA since these patients do not suffer from patellar dislocations rather than from lateralisation or subluxation. The cause of instability is mostly an incorrect positioning of the components (rotational or valgus error). MPFL reconstruction with an autologous tendon graft may increase the patellofemoral contact pressure.
A patella baja can be corrected by an osteotomy of the tibial tuberosity. With this procedure a proximalisation of one to two centimetres can be achieved.
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