Skip to main content

Advertisement

Log in

Contrast-enhanced ultrasound of the kidneys: principles and potential applications

  • Review
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Contrast-enhanced ultrasound (CEUS) is an extension and an enhanced form of ultrasound that allows real-time evaluation of the various structures in different vascular phases. The last decade has witnessed a widespread expansion of CEUS applications beyond the liver. It has shown fair potential in kidneys and its diagnostic efficacy is comparable to CT and MRI. Ultrasound is the well-accepted screening modality for renal pathologies, however, it underperforms in the characterization of the renal masses. CEUS can be beneficial in such cases as it can help in the characterization of such incidental masses in the same sitting. It has an excellent safety profile with no risk of radiation or contract-related nephropathy. It can aid in the correct categorization of renal cysts into one of the Bosniak classes and has proven its worth especially in complex cysts or indeterminate renal masses (especially Bosniak Category IIF and III). Few studies also describe its potential role in solid masses and in differentiating benign from malignant masses. Other areas of interest include infections, infarctions, trauma, follow-up of local ablative procedures, and VUR. Through this review, the readers shall get an insight into the various applications of CEUS in kidneys, with imaging examples.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13

Similar content being viewed by others

References

  1. Dietrich CF, Averkiou M, Nielsen MB, et al (2018) How to perform Contrast-Enhanced Ultrasound (CEUS). Ultrasound Int Open 4:E2–E15. https://doi.org/10.1055/s-0043-123931

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bertolotto M, Catalano O (2009) Contrast-enhanced Ultrasound: Past, Present, and Future. Ultrasound Clinics 4:339–367. https://doi.org/10.1016/j.cult.2009.10.011

    Article  Google Scholar 

  3. Sidhu PS, Cantisani V, Dietrich CF, et al (2018) The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version). Ultraschall Med 39:e2–e44. https://doi.org/10.1055/a-0586-1107

    Article  PubMed  Google Scholar 

  4. Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356–366. https://doi.org/10.1097/00004424-196809000-00011

    Article  CAS  PubMed  Google Scholar 

  5. Zhang F, Li R, Li G, et al (2019) Value of Contrast-Enhanced Ultrasound in the Diagnosis of Renal Cancer and in Comparison With Contrast-Enhanced Computed Tomography: A Meta-analysis. J Ultrasound Med 38:903–914. https://doi.org/10.1002/jum.14769

    Article  PubMed  Google Scholar 

  6. Piscaglia F, Bolondi L, Italian Society for Ultrasound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents (2006) The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 32:1369–1375. https://doi.org/10.1016/j.ultrasmedbio.2006.05.031

    Article  PubMed  Google Scholar 

  7. Girometti R, Stocca T, Serena E, et al (2017) Impact of contrast-enhanced ultrasound in patients with renal function impairment. World Journal of Radiology 9:10–16. https://doi.org/10.4329/wjr.v9.i1.10

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wilson SR, Greenbaum LD, Goldberg BB (2009) Contrast-enhanced ultrasound: what is the evidence and what are the obstacles? AJR Am J Roentgenol 193:55–60. https://doi.org/10.2214/AJR.09.2553

    Article  PubMed  Google Scholar 

  9. Bertolotto M, Cicero C, Perrone R, et al (2015) Renal Masses With Equivocal Enhancement at CT: Characterization With Contrast-Enhanced Ultrasound. American Journal of Roentgenology 204:W557–W565. https://doi.org/10.2214/AJR.14.13375

    Article  PubMed  Google Scholar 

  10. Quaia E (2005) Classification and Safety of Microbubble-Based Contrast Agents. In: Quaia E (ed) Contrast Media in Ultrasonography: Basic Principles and Clinical Applications. Springer, Berlin, Heidelberg, pp 3–14

    Chapter  Google Scholar 

  11. Dalla Palma L, Bertolotto M (1999) Introduction to ultrasound contrast agents: physics overview. Eur Radiol 9 Suppl 3:S338-342. https://doi.org/10.1007/pl00014069

    Article  PubMed  Google Scholar 

  12. Ignee A, Atkinson NSS, Schuessler G, Dietrich CF (2016) Ultrasound contrast agents. Endosc Ultrasound 5:355–362. https://doi.org/10.4103/2303-9027.193594

    Article  Google Scholar 

  13. Wilson SR, Burns PN (2010) Microbubble-enhanced US in Body Imaging: What Role? Radiology 257:24–39. https://doi.org/10.1148/radiol.10091210

    Article  PubMed  Google Scholar 

  14. Quaia E (2011) Assessment of tissue perfusion by contrast-enhanced ultrasound. Eur Radiol 21:604–615. https://doi.org/10.1007/s00330-010-1965-6

    Article  PubMed  Google Scholar 

  15. Claudon M, Dietrich CF, Choi BI, et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver--update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 34:11–29. https://doi.org/10.1055/s-0032-1325499

    Article  CAS  PubMed  Google Scholar 

  16. Eckersley RJ, Chin CT, Burns PN (2005) Optimising phase and amplitude modulation schemes for imaging microbubble contrast agents at low acoustic power. Ultrasound Med Biol 31:213–219. https://doi.org/10.1016/j.ultrasmedbio.2004.10.004

    Article  PubMed  Google Scholar 

  17. Granata A, Campo I, Lentini P, et al (2021) Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action. Diagnostics (Basel) 11:1058. https://doi.org/10.3390/diagnostics11061058

    Article  CAS  Google Scholar 

  18. Main ML, Goldman JH, Grayburn PA (2009) Ultrasound contrast agents: balancing safety versus efficacy. Expert Opin Drug Saf 8:49–56. https://doi.org/10.1517/14740330802658581

    Article  CAS  PubMed  Google Scholar 

  19. Miller DL, Dou C, Wiggins RC (2009) Glomerular Capillary Hemorrhage Induced in Rats by Diagnostic Ultrasound with Gas Body Contrast Agent Produces Intra-Tubular Obstruction. Ultrasound Med Biol 35:869–877. https://doi.org/10.1016/j.ultrasmedbio.2008.10.015

    Article  PubMed  PubMed Central  Google Scholar 

  20. Tenant SC, Gutteridge CM (2016) The clinical use of contrast-enhanced ultrasound in the kidney. Ultrasound 24:94–103. https://doi.org/10.1177/1742271X15627185

    Article  PubMed  PubMed Central  Google Scholar 

  21. Correas J-M, Claudon M, Tranquart F, Hélénon AO (2006) The kidney: imaging with microbubble contrast agents. Ultrasound Q 22:53–66

    PubMed  Google Scholar 

  22. Bosniak MA (1986) The current radiological approach to renal cysts. Radiology 158:1–10. https://doi.org/10.1148/radiology.158.1.3510019

    Article  CAS  PubMed  Google Scholar 

  23. Silverman SG, Pedrosa I, Ellis JH, et al (2019) Bosniak Classification of Cystic Renal Masses, Version 2019: An Update Proposal and Needs Assessment. Radiology 292:475–488. https://doi.org/10.1148/radiol.2019182646

    Article  PubMed  Google Scholar 

  24. Cantisani V, Bertolotto M, Clevert D-A, et al (2021) EFSUMB 2020 Proposal for a Contrast-Enhanced Ultrasound-Adapted Bosniak Cyst Categorization - Position Statement. Ultraschall Med 42:154–166. https://doi.org/10.1055/a-1300-1727

    Article  PubMed  Google Scholar 

  25. Quaia E, Bertolotto M, Cioffi V, et al (2008) Comparison of contrast-enhanced sonography with unenhanced sonography and contrast-enhanced CT in the diagnosis of malignancy in complex cystic renal masses. AJR Am J Roentgenol 191:1239–1249. https://doi.org/10.2214/AJR.07.3546

    Article  PubMed  Google Scholar 

  26. Clevert D-A, Minaifar N, Weckbach S, et al (2008) Multislice computed tomography versus contrast-enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system. Clin Hemorheol Microcirc 39:171–178

    Article  Google Scholar 

  27. Graumann O, Osther SS, Karstoft J, et al (2016) Bosniak classification system: a prospective comparison of CT, contrast-enhanced US, and MR for categorizing complex renal cystic masses. Acta Radiol 57:1409–1417. https://doi.org/10.1177/0284185115588124

    Article  PubMed  Google Scholar 

  28. Qiu X, Zhao Q, Ye Z, et al (2020) How does contrast-enhanced ultrasonography influence Bosniak classification for complex cystic renal mass compared with conventional ultrasonography? Medicine (Baltimore) 99:e19190. https://doi.org/10.1097/MD.0000000000019190

    Article  PubMed Central  Google Scholar 

  29. Nicolau C, Bunesch L, Sebastia C (2011) Renal complex cysts in adults: contrast-enhanced ultrasound. Abdom Imaging 36:742–752. https://doi.org/10.1007/s00261-011-9727-8

    Article  PubMed  Google Scholar 

  30. Nicolau C, Buñesch L, Paño B, et al (2015) Prospective evaluation of CT indeterminate renal masses using US and contrast-enhanced ultrasound. Abdom Imaging 40:542–551. https://doi.org/10.1007/s00261-014-0237-3

    Article  PubMed  Google Scholar 

  31. Ascenti G, Mazziotti S, Zimbaro G, et al (2007) Complex cystic renal masses: characterization with contrast-enhanced US. Radiology 243:158–165. https://doi.org/10.1148/radiol.2431051924

    Article  PubMed  Google Scholar 

  32. Schwarze V, Rübenthaler J, Čečatka S, et al (2020) Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Bosniak III Complex Renal Cystic Lesions-A 10-Year Specialized European Single-Center Experience with Histopathological Validation. Medicina (Kaunas) 56:E692. https://doi.org/10.3390/medicina56120692

    Article  Google Scholar 

  33. Lan D, Qu H-C, Li N, et al (2016) The Value of Contrast-Enhanced Ultrasonography and Contrast-Enhanced CT in the Diagnosis of Malignant Renal Cystic Lesions: A Meta-Analysis. PLoS One 11:e0155857. https://doi.org/10.1371/journal.pone.0155857

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Chen Y, Wu N, Xue T, et al (2015) Comparison of contrast-enhanced sonography with MRI in the diagnosis of complex cystic renal masses. J Clin Ultrasound 43:203–209. https://doi.org/10.1002/jcu.22232

    Article  CAS  PubMed  Google Scholar 

  35. Rubenthaler J, Cecatka S, Froelich MF, et al (2020) Contrast-Enhanced Ultrasound (CEUS) for Follow-Up of Bosniak 2F Complex Renal Cystic Lesions--A 12-Year Retrospective Study in a Specialized European Center. Cancers 12:1fo–1fo

    Article  Google Scholar 

  36. Yong C, Teo YM, Jeevesh K (2016) Diagnostic performance of contrast-enhanced ultrasound in the evaluation of renal masses in patients with renal impairment. Med J Malaysia 71:193–198

    CAS  PubMed  Google Scholar 

  37. Narasimhan N, Golper TA, Wolfson M, et al (1986) Clinical characteristics and diagnostic considerations in acquired renal cystic disease. Kidney Int 30:748–752. https://doi.org/10.1038/ki.1986.251

    Article  CAS  PubMed  Google Scholar 

  38. Hofmann JN, Corley DA, Zhao WK, et al (2015) Chronic kidney disease and risk of renal cell carcinoma: differences by race. Epidemiology 26:59–67. https://doi.org/10.1097/EDE.0000000000000205

    Article  PubMed  PubMed Central  Google Scholar 

  39. Christensson A, Savage C, Sjoberg DD, et al (2013) Association of cancer with moderately impaired renal function at baseline in a large, representative, population-based cohort followed for up to 30 years. Int J Cancer 133:1452–1458. https://doi.org/10.1002/ijc.28144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Lowrance WT, Ordoñez J, Udaltsova N, et al (2014) CKD and the risk of incident cancer. J Am Soc Nephrol 25:2327–2334. https://doi.org/10.1681/ASN.2013060604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Chang EH, Chong WK, Kasoji SK, et al (2017) Diagnostic accuracy of contrast-enhanced ultrasound for characterization of kidney lesions in patients with and without chronic kidney disease. BMC Nephrol 18:266. https://doi.org/10.1186/s12882-017-0681-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Barr RG, Peterson C, Hindi A (2014) Evaluation of indeterminate renal masses with contrast-enhanced US: a diagnostic performance study. Radiology 271:133–142. https://doi.org/10.1148/radiol.13130161

    Article  PubMed  Google Scholar 

  43. Bertolotto M, Bucci S, Valentino M, et al (2018) Contrast-enhanced ultrasound for characterizing renal masses. Eur J Radiol 105:41–48. https://doi.org/10.1016/j.ejrad.2018.05.015

    Article  PubMed  Google Scholar 

  44. Reuter VE, Presti JC (2000) Contemporary approach to the classification of renal epithelial tumors. Semin Oncol 27:124–137

    CAS  PubMed  Google Scholar 

  45. Pan K-H, Jian L, Chen W-J, et al (2020) Diagnostic Performance of Contrast-Enhanced Ultrasound in Renal Cancer: A Meta-Analysis. Front Oncol 10:586949. https://doi.org/10.3389/fonc.2020.586949

    Article  PubMed  PubMed Central  Google Scholar 

  46. Wang C, Yu C, Yang F, Yang G (2014) Diagnostic accuracy of contrast-enhanced ultrasound for renal cell carcinoma: a meta-analysis. Tumour Biol 35:6343–6350. https://doi.org/10.1007/s13277-014-1815-2

    Article  CAS  PubMed  Google Scholar 

  47. Geyer T, Schwarze V, Marschner C, et al (2020) Diagnostic Performance of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Solid Renal Masses. Medicina (Kaunas) 56:E624. https://doi.org/10.3390/medicina56110624

    Article  Google Scholar 

  48. Gulati M, King KG, Gill IS, et al (2015) Contrast-enhanced ultrasound (CEUS) of cystic and solid renal lesions: a review. Abdom Imaging 40:1982–1996. https://doi.org/10.1007/s00261-015-0348-5

    Article  PubMed  Google Scholar 

  49. Bertolotto M, Cicero C, Catalano O, et al (2018) Solid Renal Tumors Isoenhancing to Kidneys on Contrast-Enhanced Sonography: Differentiation From Pseudomasses. Journal of Ultrasound in Medicine 37:233–242. https://doi.org/10.1002/jum.14335

    Article  PubMed  Google Scholar 

  50. Tamai H, Takiguchi Y, Oka M, et al (2005) Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med 24:1635–1640. https://doi.org/10.7863/jum.2005.24.12.1635

    Article  PubMed  Google Scholar 

  51. Liu H, Cao H, Chen L, et al (2022) The quantitative evaluation of contrast-enhanced ultrasound in the differentiation of small renal cell carcinoma subtypes and angiomyolipoma. Quantitative Imaging in Medicine and Surgery 12:10618–10118. https://doi.org/10.21037/qims-21-248

    Article  Google Scholar 

  52. Xu Z-F, Xu H-X, Xie X-Y, et al (2010) Renal cell carcinoma and renal angiomyolipoma: differential diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med 29:709–717. https://doi.org/10.7863/jum.2010.29.5.709

    Article  PubMed  Google Scholar 

  53. Lu Q, Li C, Huang B, et al (2015) Triphasic and epithelioid minimal fat renal angiomyolipoma and clear cell renal cell carcinoma: qualitative and quantitative CEUS characteristics and distinguishing features. Abdom Imaging 40:333–342. https://doi.org/10.1007/s00261-014-0221-y

    Article  PubMed  Google Scholar 

  54. Wu Y, Du L, Li F, et al (2013) Renal oncocytoma: contrast-enhanced sonographic features. J Ultrasound Med 32:441–448. https://doi.org/10.7863/jum.2013.32.3.441

    Article  PubMed  Google Scholar 

  55. Mazziotti S, Zimbaro F, Pandolfo A, et al (2010) Usefulness of contrast-enhanced ultrasonography in the diagnosis of renal pseudotumors. Abdom Imaging 35:241–245. https://doi.org/10.1007/s00261-008-9499-y

    Article  PubMed  Google Scholar 

  56. Granata A, Zanoli L, Insalaco M, et al (2015) Contrast-enhanced ultrasound (CEUS) in nephrology: Has the time come for its widespread use? Clin Exp Nephrol 19:606–615. https://doi.org/10.1007/s10157-014-1040-8

    Article  PubMed  Google Scholar 

  57. Bertolotto M, Martegani A, Aiani L, et al (2008) Value of contrast-enhanced ultrasonography for detecting renal infarcts proven by contrast enhanced CT. A feasibility study. Eur Radiol 18:376–383. https://doi.org/10.1007/s00330-007-0747-2

    Article  PubMed  Google Scholar 

  58. Yusuf GT, Sellars ME, Huang DY, et al (2014) Cortical necrosis secondary to trauma in a child: contrast-enhanced ultrasound comparable to magnetic resonance imaging. Pediatr Radiol 44:484–487. https://doi.org/10.1007/s00247-013-2818-7

    Article  PubMed  Google Scholar 

  59. Fontanilla T, Minaya J, Cortés C, et al (2012) Acute complicated pyelonephritis: contrast-enhanced ultrasound. Abdom Imaging 37:639–646. https://doi.org/10.1007/s00261-011-9781-2

    Article  PubMed  Google Scholar 

  60. Jung HJ, Choi MH, Pai KS, Kim HG (2020) Diagnostic performance of contrast-enhanced ultrasound for acute pyelonephritis in children. Sci Rep 10:10715. https://doi.org/10.1038/s41598-020-67713-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Goyal A, Hemachandran N, Kumar A, et al (2020) Evaluation of the Graft Kidney in the Early Postoperative Period: Performance of Contrast-Enhanced Ultrasound and Additional Ultrasound Parameters. J Ultrasound Med. https://doi.org/10.1002/jum.15557

    Article  PubMed  Google Scholar 

  62. Cantisani V, Bertolotto M, Weskott HP, et al (2015) Growing indications for CEUS: The kidney, testis, lymph nodes, thyroid, prostate, and small bowel. Eur J Radiol 84:1675–1684. https://doi.org/10.1016/j.ejrad.2015.05.008

    Article  CAS  PubMed  Google Scholar 

  63. Stacul F, Sachs C, Giudici F, et al (2021) Cryoablation of renal tumors: long-term follow-up from a multicenter experience. Abdom Radiol 46:4476–4488. https://doi.org/10.1007/s00261-021-03082-z

    Article  Google Scholar 

  64. Lackey L, Peterson C, Barr RG (2012) Contrast-enhanced ultrasound-guided radiofrequency ablation of renal tumors. Ultrasound Q 28:269–274. https://doi.org/10.1097/RUQ.0b013e318274de66

    Article  PubMed  Google Scholar 

  65. Xu L, Rong Y, Wang W, et al (2016) Percutaneous radiofrequency ablation with contrast-enhanced ultrasonography for solitary and sporadic renal cell carcinoma in patients with autosomal dominant polycystic kidney disease. World J Surg Oncol 14:193. https://doi.org/10.1186/s12957-016-0916-3

    Article  PubMed  PubMed Central  Google Scholar 

  66. Johnson DB, Duchene DA, Taylor GD, et al (2005) Contrast-enhanced ultrasound evaluation of radiofrequency ablation of the kidney: reliable imaging of the thermolesion. J Endourol 19:248–252. https://doi.org/10.1089/end.2005.19.248

    Article  PubMed  Google Scholar 

  67. Cokkinos DD, Antypa EG, Skilakaki M, et al (2013) Contrast Enhanced Ultrasound of the Kidneys: What Is It Capable of? BioMed Research International 2013:e595873. https://doi.org/10.1155/2013/595873

    Article  Google Scholar 

  68. Boss A, Clasen S, Kuczyk M, et al (2007) Image-guided radiofrequency ablation of renal cell carcinoma. Eur Radiol 17:725–733. https://doi.org/10.1007/s00330-006-0415-y

    Article  PubMed  Google Scholar 

  69. O’Neal D, Cohen T, Peterson C, Barr RG (2018) Contrast-Enhanced Ultrasound-Guided Radiofrequency Ablation of Renal Tumors. J Kidney Cancer VHL 5:7–14. https://doi.org/10.15586/jkcvhl.2018.100

    Article  PubMed  PubMed Central  Google Scholar 

  70. Hoeffel C, Pousset M, Timsit M-O, et al (2010) Radiofrequency ablation of renal tumours: diagnostic accuracy of contrast-enhanced ultrasound for early detection of residual tumour. Eur Radiol 20:1812–1821. https://doi.org/10.1007/s00330-010-1742-6

    Article  PubMed  Google Scholar 

  71. Bertolotto M, Campo I, Sachs C, et al (2021) Contrast-enhanced ultrasound after successful cryoablation of benign and malignant renal tumours: how long does tumour enhancement persist? J Med Imaging Radiat Oncol 65:272–278. https://doi.org/10.1111/1754-9485.13149

    Article  PubMed  Google Scholar 

  72. Sessa B, Trinci M, Ianniello S, et al (2015) Blunt abdominal trauma: role of contrast-enhanced ultrasound (CEUS) in the detection and staging of abdominal traumatic lesions compared to US and CE-MDCT. Radiol Med 120:180–189. https://doi.org/10.1007/s11547-014-0425-9

    Article  PubMed  Google Scholar 

  73. Paajanen H, Lahti P, Nordback I (1999) Sensitivity of transabdominal ultrasonography in detection of intraperitoneal fluid in humans. Eur Radiol 9:1423–1425. https://doi.org/10.1007/s003300050861

    Article  CAS  PubMed  Google Scholar 

  74. Chiu WC, Cushing BM, Rodriguez A, et al (1997) Abdominal injuries without hemoperitoneum: a potential limitation of focused abdominal sonography for trauma (FAST). J Trauma 42:617–623; discussion 623-625. https://doi.org/10.1097/00005373-199704000-00006

    Article  CAS  PubMed  Google Scholar 

  75. Morey AF, Brandes S, Dugi DD, et al (2014) Urotrauma: AUA guideline. J Urol 192:327–335. https://doi.org/10.1016/j.juro.2014.05.004

    Article  PubMed  PubMed Central  Google Scholar 

  76. Bowen DK, Back SJ, Van Batavia JP, et al (2020) Does contrast-enhanced ultrasound have a role in evaluation and management of pediatric renal trauma? A preliminary experience. J Pediatr Surg 55:2740–2745. https://doi.org/10.1016/j.jpedsurg.2020.06.010

    Article  PubMed  Google Scholar 

  77. Piscaglia F, Nolsøe C, Dietrich CF, et al (2012) The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 33:33–59. https://doi.org/10.1055/s-0031-1281676

    Article  CAS  PubMed  Google Scholar 

  78. Cagini L, Gravante S, Malaspina CM, et al (2013) Contrast enhanced ultrasound (CEUS) in blunt abdominal trauma. Crit Ultrasound J 5 Suppl 1:S9. https://doi.org/10.1186/2036-7902-5-S1-S9

    Article  PubMed  PubMed Central  Google Scholar 

  79. Regine G, Atzori M, Miele V, et al (2007) Second-generation sonographic contrast agents in the evaluation of renal trauma. Radiol Med 112:581–587. https://doi.org/10.1007/s11547-007-0164-2

    Article  CAS  PubMed  Google Scholar 

  80. Ntoulia A, Aguirre Pascual E, Back SJ, et al (2021) Contrast-enhanced voiding urosonography, part 1: vesicoureteral reflux evaluation. Pediatr Radiol 51:2351–2367. https://doi.org/10.1007/s00247-020-04906-8

    Article  PubMed  Google Scholar 

  81. Drudi FM, Angelini F, Bertolotto M, et al (2021) Role of Contrast-Enhanced Voiding Urosonography in the Evaluation of Renal Transplant Reflux - Comparison with Voiding Cystourethrography and a New Classification. Ultraschall Med. https://doi.org/10.1055/a-1288-0075

    Article  PubMed  Google Scholar 

  82. Huang DY, Yusuf GT, Daneshi M, et al (2018) Contrast-enhanced ultrasound (CEUS) in abdominal intervention. Abdom Radiol (NY) 43:960–976. https://doi.org/10.1007/s00261-018-1473-8

    Article  Google Scholar 

  83. Guo X, Zhang Z, Liu Z, et al (2021) Assessment of the Contrast-Enhanced Ultrasound in Percutaneous Nephrolithotomy for the Treatment of Patients with Nondilated Collecting System. Journal of Endourology 35:436–443. https://doi.org/10.1089/end.2020.0564

    Article  PubMed  Google Scholar 

  84. Shen C, Zhang B, Han WK, et al (2017) [Percutaneous renal access for percutaneous nephrolithotomy guided by contrast enhanced ultrasound: a single-center preliminary experience in China]. Beijing Da Xue Xue Bao Yi Xue Ban 49:1071–1075

    CAS  PubMed  Google Scholar 

  85. Como G, Da Re J, Adani GL, et al (2020) Role for contrast-enhanced ultrasound in assessing complications after kidney transplant. World J Radiol 12:156–171. https://doi.org/10.4329/wjr.v12.i8.156

    Article  PubMed  PubMed Central  Google Scholar 

  86. Yoon HE, Kim DW, Kim D, et al (2020) A pilot trial to evaluate the clinical usefulness of contrast-enhanced ultrasound in predicting renal outcomes in patients with acute kidney injury. PLOS ONE 15:e0235130. https://doi.org/10.1371/journal.pone.0235130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

No funding received.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chandan J. Das.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aggarwal, A., Goswami, S. & Das, C.J. Contrast-enhanced ultrasound of the kidneys: principles and potential applications. Abdom Radiol 47, 1369–1384 (2022). https://doi.org/10.1007/s00261-022-03438-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-022-03438-z

Keywords

Navigation