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Quantitative evaluation of hepatic fibrosis by fibro Scan and Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging in chronic hepatitis B

  • Hepatobiliary
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Abstract

Purpose

Studies have found that both FibroScan (FS) and Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging (Gd-MRI) could assess liver fibrosis (LF) with high effectiveness. The aim of this study is to compare their accuracy in the quantitative evaluation of LF in patients with chronic hepatitis B (CHB), and to explore the diagnostic accuracy of their combination.

Methods

160 patients with CHB were included in this study. FS and Gd-MRI were performed within 3 months before the pathological LF staging, which was classified according to the Scheuer-Ludwig scale. The liver stiffness measurement (LSM) was obtained by FS. T1 mapping images of the liver before and 20 min after enhancement were obtained by Look-Locker Gd-MRI.

Results

There were 45, 35, 31 and 49 patients with stage S1, S2, S3 and S4 LF, respectively. LSM increased and the reduction rate of T1 relaxation time of 20 min (rrT120min%) decreased with the severity of LF. The area under curve (AUC) of LSM, rrT120min% and LSM + rrT120min% for the diagnosis of ≥ S2 LF were 0.892, 0.811 and 0.900, respectively. The AUC for ≥ S3 LF was 0.883, 0.838 and 0.899, respectively. The AUC for S4 LF was 0.882, 0.894 and 0.928, respectively.

Conclusion

The diagnostic accuracy of FS is better than that of Gd-MRI in the evaluation of ≥ S2 stage LF. The combination of these two methods significantly improved the diagnostic efficiency in the evaluation of S4 stage LF.

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Data availability

All data and materials support the published claims.

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Funding

This work was funded by the Shanghai Hospital Development Center (Grant No.SHDC1209128).

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Author notes

  1. Tianyou Chen and Qingtao Li have equally contributed to this work.

Authors and Affiliations

  1. Department of Intervention, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China

    Qingtao Li, Tianyou Chen & Min Yuan

  2. Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, No. 2901, Caolang Road, Shanyang Town, Jinshan District, Shanghai, 201508, People’s Republic of China

    Nannan Shi, Wen Ye & Yuxin Shi

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  1. Qingtao Li
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Contributions

Conceptualization: Yuxin Shi. Data curation: Yuxin Shi, Qingtao Li, Tianyou Chen. Formal analysis: Yuxin Shi. Investigation: Yuxin Shi, Qingtao Li. Methodology: All authors. Project administration: Yuxin Shi. Supervision: Yuxin Shi. Writing—original draft: Yuxin Shi, Qingtao Li. Writing—review & editing: Yuxin Shi.

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Correspondence to Yuxin Shi.

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Li, Q., Chen, T., Shi, N. et al. Quantitative evaluation of hepatic fibrosis by fibro Scan and Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging in chronic hepatitis B. Abdom Radiol 47, 684–692 (2022). https://doi.org/10.1007/s00261-021-03300-8

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