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Calculating colon transit time withradionuclide-filled capsules in constipated patients: a new method for colon transit study

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Abstract

Background

Colon motility disorders require reliable methods for calculating segmental colonic transit time. This study evaluated bowel transit time by means of a safe, easy, cheap, nondigestive, and nondisintegrating radionuclide-filled capsule that provided accurate and clear images.

Methods

Radionuclide-filled minicontainers (MCs) were prepared from infusion sets by an apparatus used for sealing blood bags or plasmapheresis sets. In vitro stability studies were performed by immersing 5% methylene blue dye-filled MCs in buffers of variable pH and enzymes simulating the conditions in the stomach and the small bowel. Colon transit scintigraphy was performed with MCs filled with iodine 131 (n = 5) and thallium 201 (n = 8) that were placed in a commercially available capsule.

Results

By in vitro acid, base, and intestinal enzyme resistance tests, no methylene blue leakage was determined visually and by spectrophotometric analysis. Accurate and clear images were obtained for colon transit study in constipated patients. After excretion of MCs in the feces, abdominal, myocardial, thyroid, and urinary bladder region counts were found to show the same activity as the background. Radionuclide leakage from MCs was not determined in vivo by gamma camera.

Conclusions

This is a suitable, safe, easy, and cheap method to provide accurate and clear images for colon transit study in constipated patients.

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References

  1. V Stanghellini C Tosetti R Corinaldesi (2000) ArticleTitleStandards for non-invasive methods for gastrointestinal motility: scintigraphy. A position statement from the Gruppo Italiano di Studio Motilita Apparato Digerente (GISMAD) Dig Liver Dis 32 447–452 Occurrence Handle10.1016/S1590-8658(00)80267-4 Occurrence Handle11030192

    Article  PubMed  Google Scholar 

  2. DBA Silk ER Walters HD Duncan CJ Green (2001) ArticleTitleThe eject of a polymeric enteral formula supplemented with a mixture of six fibres on normal human bowel function and colonic motility Clin Nutr 20 49–58 Occurrence Handle10.1054/clnu.2000.0359 Occurrence Handle11161544

    Article  PubMed  Google Scholar 

  3. G Sathyan S Hwang SK Gupta (2000) ArticleTitleEffect of dosing time on the total intestinal transit time of non-disintegrating systems Int J Pharm 204 47–51 Occurrence Handle10.1016/S0378-5173(00)00472-5 Occurrence Handle11011985

    Article  PubMed  Google Scholar 

  4. AW Basit JM Newton MD Short et al. (2001) ArticleTitleThe effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly-water soluble drugs Pharm Res 18 1146–1150 Occurrence Handle10.1023/A:1010927026837 Occurrence Handle11587486

    Article  PubMed  Google Scholar 

  5. A McIntyre RM Vincent AC Perkins RC Spiller (1997) ArticleTitleEffect of bran, ispaghula, and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors Gut 40 223–227 Occurrence Handle9071936

    PubMed  Google Scholar 

  6. AH Maurer B Krevsky (1995) ArticleTitleWhole-gut transit scintigraphy in the evaluation of small-bowel and colon transit disorders Semin Nucl Med 25 326–338 Occurrence Handle8545637

    PubMed  Google Scholar 

  7. HJ Mason E Serrano-Ikkos MA Kamm (2000) ArticleTitlePsychological morbidity in women with idiopathic constipation Am J Gastroenterol 95 2852–2857 Occurrence Handle10.1111/j.1572-0241.2000.02313.x Occurrence Handle11051359

    Article  PubMed  Google Scholar 

  8. R Chattat G Bazzocchi M Balloni et al. (1997) ArticleTitleIllness behavior, affective disturbance and intestinal transit time in idiopathic constipation J Psychosom Res 42 95–100 Occurrence Handle10.1016/S0022-3999(96)00217-6 Occurrence Handle9055217

    Article  PubMed  Google Scholar 

  9. RW Prokesch MJ Breitenseher J Kettenbach et al. (1999) ArticleTitleAssessment of chronic constipation: colon transit time versus defecography Eur J Radiol 32 197–203 Occurrence Handle10.1016/S0720-048X(99)00037-6 Occurrence Handle10632558

    Article  PubMed  Google Scholar 

  10. E Miele A Tozzi A Staiano et al. (2000) ArticleTitlePersistence of abnormal gastrointestinal motility after operation for Hirschsprung’s disease Am J Gastroenterol 95 1226–1230 Occurrence Handle10.1111/j.1572-0241.2000.02014.x Occurrence Handle10811332

    Article  PubMed  Google Scholar 

  11. J Olmos L Soifer JA Paula ParticleDe et al. (1994) ArticleTitleDo the physical characteristics of radiopaque markers modify the results of the measurement of colonic transit time? (in Spanish) Acta Gastroenterol Latinoam 25 287–290 Occurrence Handle7785400

    PubMed  Google Scholar 

  12. SJ Wang SC Tsai WY Lin GH Chen (2000) ArticleTitleA simple method for preparing radioactive capsules in colon transit study Eur J Nucl Med 27 857–860 Occurrence Handle10.1007/s002590000269 Occurrence Handle10952498

    Article  PubMed  Google Scholar 

  13. JRM Sijp Particlevan der MA Kamm JMD Nightingale et al. (1993) ArticleTitleRadioisotope determination of regional colonic transit in severe constipation: comparison with radiopaque markers Gut 34 402–408 Occurrence Handle8472991

    PubMed  Google Scholar 

  14. D Bartholomeusz BE Chatterton JC Bellen et al. (1999) ArticleTitleSegmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation J Nucl Med 40 277–282 Occurrence Handle10025835

    PubMed  Google Scholar 

  15. RC Smart RG McLean D Gaston-Parry et al. (1991) ArticleTitleComparison of oral iodine-131-cellulose and indium-111-DTPA as tracers for colon transit scintigraphy: analysis by colon activity profiles J Nucl Med 32 1668–1674 Occurrence Handle1880566

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Turgut Ozal Medical Center, Inonu University, Malatya, 44069, Turkey

    E. Kekilli, C. Yagmur & O. M. Aydin

  2. Department of General Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, 44069, Turkey

    B. Isik

Authors
  1. E. Kekilli
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  2. C. Yagmur
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  3. B. Isik
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  4. O. M. Aydin
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Correspondence to E. Kekilli.

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Kekilli, E., Yagmur, C., Isik, B. et al. Calculating colon transit time withradionuclide-filled capsules in constipated patients: a new method for colon transit study. Abdom Imaging 30, 593–597 (2005). https://doi.org/10.1007/s00261-005-0305-9

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  • DOI: https://doi.org/10.1007/s00261-005-0305-9

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