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Histological and imaging features of myoepithelial carcinoma of the bone and soft tissue

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Skeletal Radiology Aims and scope Submit manuscript

Abstract

Objective

To depict histological and imaging features of myoepithelial carcinoma of the bone and soft tissue.

Materials and methods

We retrospectively examined histological features in 22 patients with myoepithelial carcinoma of the bone (4 patients) and soft tissue (18 patients) at a single institution. Imaging analysis of 15 patients (bone, 3 patients; soft tissue, 12 patients;) with preoperative images involved classifying lytic bone lesions via the modified Lodwick–Madewell classification; the growth patterns of soft tissue lesions were classified as well-defined, focally invasive, or diffusely invasive.

Results

Local recurrence occurred in eight out of 22 patients (36.3%). Four of 22 patients (18.2%) had metastasis at presentation, whereas 11 of 22 patients (50.0%) had distant metastasis during follow-up. Severe cytological pleomorphism was observed in 14 of 22 patients (63.6%), and 10 of 22 tumors (45.5%) showed ≥ 10 mitoses/10 high-power fields. Vascular invasion was observed in 10 of 22 patients (45.5%). Extracapsular/extraskeletal infiltration into the surrounding tissues was assessed in 20 patients, with 14 of them (70%) showing infiltration beyond the tumor border. Regarding imaging of bone lesions, two patients had Ludwick type IIIB, whereas one patient had type II. The growth pattern of soft tissue lesions was well-defined in two patients (16.7%), focally invasive in seven patients (58.3%), and diffusely invasive in three (25.0%) out of 12 patients.

Conclusion

Myoepithelial carcinoma of the bone and soft tissue presents high risk of local recurrence and distant metastasis. Histological and imaging features might be important to understand the aggressive behavior of the tumor.

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Data availability

In safeguarding privacy, providing the data is withheld. Requisite details are furnished within the supplementary table.

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Authors and Affiliations

  1. Clinica Ortopedica e Traumatologica III a Prevalente Indirizzo Oncologico, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy

    Hisaki Aiba, Ahmed Atherley O’Meally, Ayano Aso, Konstantina Solou, Davide Maria Donati & Costantino Errani

  2. Department of Orthopaedic Surgery, Nagoya City University, Nagoya, Japan

    Hisaki Aiba

  3. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Alberto Righi & Marco Gambarotti

  4. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Paolo Spinnato

  5. Osteoncology, Bone and Soft Tissue Sarcomas, and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Alessandra Longhi, Giorgio Frega & Toni Ibrahim

  6. Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy

    Barbara Dozza & Davide Maria Donati

Authors
  1. Hisaki Aiba
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  2. Alberto Righi
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  3. Paolo Spinnato
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  4. Alessandra Longhi
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  6. Ahmed Atherley O’Meally
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  7. Ayano Aso
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  8. Konstantina Solou
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  9. Barbara Dozza
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  10. Marco Gambarotti
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  11. Toni Ibrahim
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  12. Davide Maria Donati
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  13. Costantino Errani
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Corresponding author

Correspondence to Hisaki Aiba.

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Ethics statement

All procedures involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Institutional Review Board (approval number: CE-AVEC 642/2023/Oss/IOR). The requirement for informed consent was waived for this study due to its retrospective nature.

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Aiba, H., Righi, A., Spinnato, P. et al. Histological and imaging features of myoepithelial carcinoma of the bone and soft tissue. Skeletal Radiol (2024). https://doi.org/10.1007/s00256-024-04693-5

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  • DOI: https://doi.org/10.1007/s00256-024-04693-5

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